|
|
|
|
|
||
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 108, Issue 1 1-6, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
PM Lansdorp
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada.
Hematopoietic stem cells have typically been defined as pluripotent cells with self-renewal capacity. Recent studies have shown striking differences in the mean length of telomeric repeat sequences at the end of chromosomes from human hematopoietic cells at different stages of development. The most likely explanation for these observations is that hematopoietic stem cells, like all other somatic cells studied to date, lose telomeric DNA upon each cell division. In this review, limitations in the replicative potential of hematopoietic stem cells are discussed in the context of possible clinical use of such cells for transplantation and gene therapy.
This article has been cited by other articles:
|
|
 |
|
  J. O. d. Buijs, M. Musters, T. Verrips, J. A. Post, B. Braam, and N. van Riel Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2651 - H2658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Engelhardt, J. Finke, N. Rufer, T. H. Brummendorf, B. Chapuis, C. Helg, P. M. Lansdorp, and E. Roosnek Does telomere shortening count? Blood, August 1, 2001; 98(3): 888 - 890. [Full Text] [PDF]
|
|
|
|
|
|
T. H. Brummendorf, T. L. Holyoake, N. Rufer, M. J. Barnett, M. Schulzer, C. J. Eaves, A. C. Eaves, and P. M. Lansdorp Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry Blood, March 15, 2000; 95(6): 1883 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rufer, T. H. Brummendorf, S. Kolvraa, C. Bischoff, K. Christensen, L. Wadsworth, M. Schulzer, and P. M. Lansdorp Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood J. Exp. Med., July 19, 1999; 190(2): 157 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Ball, F. M. Gibson, S. Rizzo, J. A. Tooze, J. C.W. Marsh, and E. C. Gordon-Smith Progressive Telomere Shortening in Aplastic Anemia Blood, May 15, 1998; 91(10): 3582 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mayani and P. M. Lansdorp Biology of Human Umbilical Cord Blood-Derived Hematopoietic Stem/Progenitor Cells Stem Cells, May 1, 1998; 16(3): 153 - 165. [Abstract] [Full Text]
|
|
|
|
|
|
M. Engelhardt, R. Kumar, J. Albanell, R. Pettengell, W. Han, and M. A.S. Moore Telomerase Regulation, Cell Cycle, and Telomere Stability in Primitive Hematopoietic Cells Blood, July 1, 1997; 90(1): 182 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kelemen Reproductive Capability of Yolk Sac Stem Cells Stem Cells, September 1, 1996; 14(5): 603 - 604. [Full Text] [PDF]
|
|
