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Journal of Cell Science, Vol 108, Issue 6 2231-2239, Copyright © 1995 by Company of Biologists
JOURNAL ARTICLES |
KR Matthews, T Sherwin and K Gull
School of Biological Sciences, University of Manchester, UK.
The cell cycle of the African trypanosome requires a precise orchestration of nuclear and mitochondrial genome (kinetoplast) positioning to ensure faithful segregation during division. The controls underlying these events must be subject to modulation, however, as the respective positioning of these organelles changes during the parasite's complex life cycle. We have studied mitochondrial DNA repositioning during differentiation between the trypanosome's bloodstream and procyclic form. We have found that repositioning occurs simultaneously with the DNA replication phase of the cell cycle of the differentiating parasite. Furthermore, we demonstrate, at the cell and individual microtubule level, that this organelle repositioning is achieved via microtubule-dependent processes. Our results have implications for the control of cell differentiation and division in African trypanosomes.
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This article has been cited by other articles:
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  A. Paterou, P. Walrad, P. Craddy, K. Fenn, and K. Matthews Identification and Stage-specific Association with the Translational Apparatus of TbZFP3, a CCCH Protein That Promotes Trypanosome Life-cycle Development J. Biol. Chem., December 22, 2006; 281(51): 39002 - 39013. [Abstract] [Full Text] [PDF]
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 B. Szoor, J. Wilson, H. McElhinney, L. Tabernero, and K. R. Matthews Protein tyrosine phosphatase TbPTP1: a molecular switch controlling life cycle differentiation in trypanosomes J. Cell Biol., October 23, 2006; 175(2): 293 - 303. [Abstract] [Full Text] [PDF]
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 X. Tu, J. Mancuso, W. Z. Cande, and C. C. Wang Distinct cytoskeletal modulation and regulation of G1-S transition in the two life stages of Trypanosoma brucei J. Cell Sci., October 1, 2005; 118(19): 4353 - 4364. [Abstract] [Full Text] [PDF]
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 X. Tu and C. C. Wang Pairwise Knockdowns of cdc2-Related Kinases (CRKs) in Trypanosoma brucei Identified the CRKs for G1/S and G2/M Transitions and Demonstrated Distinctive Cytokinetic Regulations between Two Developmental Stages of the Organism Eukaryot. Cell, April 1, 2005; 4(4): 755 - 764. [Abstract] [Full Text] [PDF]
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K. R. Matthews The developmental cell biology of Trypanosoma brucei J. Cell Sci., January 15, 2005; 118(2): 283 - 290. [Abstract] [Full Text] [PDF]
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 M. Engstler and M. Boshart Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei Genes & Dev., November 15, 2004; 18(22): 2798 - 2811. [Abstract] [Full Text] [PDF]
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X. Tu and C. C. Wang The Involvement of Two cdc2-related Kinases (CRKs) in Trypanosoma brucei Cell Cycle Regulation and the Distinctive Stage-specific Phenotypes Caused by CRK3 Depletion J. Biol. Chem., May 7, 2004; 279(19): 20519 - 20528. [Abstract] [Full Text] [PDF]
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A. E. Gruszynski, A. DeMaster, N. M. Hooper, and J. D. Bangs Surface Coat Remodeling during Differentiation of Trypanosoma brucei J. Biol. Chem., June 27, 2003; 278(27): 24665 - 24672. [Abstract] [Full Text] [PDF]
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 M. W. Timms, F. J. van Deursen, E. F. Hendriks, and K. R. Matthews Mitochondrial Development during Life Cycle Differentiation of African Trypanosomes: Evidence for a Kinetoplast-dependent Differentiation Control Point Mol. Biol. Cell, October 1, 2002; 13(10): 3747 - 3759. [Abstract] [Full Text] [PDF]
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M. Tasker, J. Wilson, M. Sarkar, E. Hendriks, and K. Matthews A Novel Selection Regime for Differentiation Defects Demonstrates an Essential Role for the Stumpy Form in the Life Cycle of the African Trypanosome Mol. Biol. Cell, May 1, 2000; 11(5): 1905 - 1917. [Abstract] [Full Text]
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H Field, B. Ali, T Sherwin, K Gull, S. Croft, and M. Field TbRab2p, a marker for the endoplasmic reticulum of Trypanosoma brucei, localises to the ERGIC in mammalian cells J. Cell Sci., January 1, 1999; 112(2): 147 - 156. [Abstract] [PDF]
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K. Matthews and K Gull Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form J. Cell Sci., January 10, 1997; 110(20): 2609 - 2618. [Abstract] [PDF]
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C. Vedrenne, C. Giroud, D. R. Robinson, S. Besteiro, C. Bosc, F. Bringaud, and T. Baltz Two Related Subpellicular Cytoskeleton-associated Proteins in Trypanosoma brucei Stabilize Microtubules Mol. Biol. Cell, March 1, 2002; 13(3): 1058 - 1070. [Abstract] [Full Text] [PDF]
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