spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Straub, K. L.
Right arrow Articles by Leptin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Straub, K. L.
Right arrow Articles by Leptin, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 109, Issue 1 263-270, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

The gelsolin-related flightless I protein is required for actin distribution during cellularisation in Drosophila

KL Straub, MC Stella and M Leptin
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany.

We have analysed the developmental defects in Drosophila embryos lacking a gelsolin-related protein encoded by the gene flightless I. Such embryos have previously been reported to gastrulate abnormally. We now show that the most dramatic defects are seen earlier, in actin-dependent events during cellularisation of the syncytial blastoderm, a process with similarities to cytokinesis. The blastoderm nuclei migrate to the periphery of the egg normally but lose their precise cortical positioning during cellularisation. Cleavage membranes are initially formed, but invaginate irregularly and often fail to close at the basal end of the newly formed cells. The association of actin with the cellularisation membranes is irregular, suggesting a role for flightless I in the delivery of actin to the actin network, or in its stabilisation.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
H. Deng, D. Xia, B. Fang, and H. Zhang
The Flightless I Homolog, fli-1, Regulates Anterior/Posterior Polarity, Asymmetric Cell Division and Ovulation During Caenorhabditis elegans Development
Genetics, October 1, 2007; 177(2): 847 - 860.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Q. Tao, B. Lloyd, S. Lang, D. Houston, A. Zorn, and C. Wylie
A novel G protein-coupled receptor, related to GPR4, is required for assembly of the cortical actin skeleton in early Xenopus embryos
Development, June 15, 2005; 132(12): 2825 - 2836.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. D. Campbell, S. Fountain, I. S. McLennan, L. A. Berven, M. F. Crouch, D. A. Davy, J. A. Hooper, K. Waterford, K.-S. Chen, J. R. Lupski, et al.
Fliih, a Gelsolin-Related Cytoskeletal Regulator Essential for Early Mammalian Embryonic Development
Mol. Cell. Biol., May 15, 2002; 22(10): 3518 - 3526.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Noegel and M Schleicher
The actin cytoskeleton of Dictyostelium: a story told by mutants
J. Cell Sci., January 3, 2000; 113(5): 759 - 766.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-T. Liu and H. L. Yin
Identification of the Binding Partners for Flightless I, A Novel Protein Bridging the Leucine-rich Repeat and the Gelsolin Superfamilies
J. Biol. Chem., April 3, 1998; 273(14): 7920 - 7927.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1996