|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 109, Issue 10 2423-2427, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
JM Avis and PR Clarke
School of Biological Sciences, University of Manchester, UK.
Ran is a small GTPase that has been implicated in a variety of nuclear processes, including the maintainance of nuclear structure, protein import, mRNA processing and export, and cell cycle regulation. There has been significant progress in determining the role of Ran in nuclear protein import. However, it has been unclear whether this role is sufficient to account for the diverse effects of disrupting Ran functions. Recently, several proteins have been identified that bind specifically to Ran and are, therefore, possible effectors. Other experiments using dominant mutants of Ran that block its GTP/GDP cycle have suggested that Ran may have multiple roles. Here, these results are summarised and discussed with respect to the action of Ran.
This article has been cited by other articles:
|
|
 |
|
  Q. Zhao, S. Leung, A. H. Corbett, and I. Meier Identification and Characterization of the Arabidopsis Orthologs of Nuclear Transport Factor 2, the Nuclear Import Factor of Ran Plant Physiology, March 1, 2006; 140(3): 869 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamada, I. W. Mattaj, and Y. Yoneda An ATP-dependent Activity That Releases RanGDP from NTF2 J. Biol. Chem., August 27, 2004; 279(35): 36228 - 36234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Nicolas, W. J. Moore, C. Zhang, and P. R. Clarke XMog1, a nuclear Ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe Mog1p that co-operates with RanBP1 to control generation of Ran-GTP J. Cell Sci., March 10, 2002; 114(16): 3013 - 3023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Czubryt, J. A. Austria, and G. N. Pierce Hydrogen Peroxide Inhibition of Nuclear Protein Import Is Mediated by the Mitogen-activated Protein Kinase, ERK2 J. Cell Biol., January 10, 2000; 148(1): 7 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Yaseen and G. Blobel GTP Hydrolysis Links Initiation and Termination of Nuclear Import on the Nucleoporin Nup358 J. Biol. Chem., September 10, 1999; 274(37): 26493 - 26502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakashima, E. Noguchi, and T. Nishimoto Saccharomyces cerevisiae Putative G Protein, Gtr1p, Which Forms Complexes With Itself and a Novel Protein Designated as Gtr2p, Negatively Regulates the Ran/Gsp1p G Protein Cycle Through Gtr2p Genetics, July 1, 1999; 152(3): 853 - 867. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Novoa, M. G. Rush, and P. D'Eustachio Isolated Mammalian and Schizosaccharomyces pombe Ran-binding Domains Rescue S. pombe sbp1 (RanBP1) Genomic Mutants Mol. Biol. Cell, July 1, 1999; 10(7): 2175 - 2190. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. R. Yaseen and G. Blobel Two distinct classes of Ran-binding sites on the nucleoporin Nup-358 PNAS, May 11, 1999; 96(10): 5516 - 5521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hieda, T. Tachibana, F. Yokoya, S. Kose, N. Imamoto, and Y. Yoneda A Monoclonal Antibody to the COOH-terminal Acidic Portion of Ran Inhibits Both the Recycling of Ran and Nuclear Protein Import in Living Cells J. Cell Biol., February 22, 1999; 144(4): 645 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oki and T. Nishimoto A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae Ran homologue PNAS, December 22, 1998; 95(26): 15388 - 15393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakamura, H. Masuda, J. Horii, K.-i. Kuma, N. Yokoyama, T. Ohba, H. Nishitani, T. Miyata, M. Tanaka, and T. Nishimoto When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to gamma -Tubulin J. Cell Biol., November 16, 1998; 143(4): 1041 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Hughes, C Zhang, J. Avis, C. Hutchison, and P. Clarke The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants J. Cell Sci., January 10, 1998; 111(20): 3017 - 3026. [Abstract] [PDF]
|
|
|
|
|
|
T. Taura, G. Schlenstedt, and P. A. Silver Yrb2p Is a Nuclear Protein That Interacts with Prp20p, a Yeast Rcc1 Homologue J. Biol. Chem., December 12, 1997; 272(50): 31877 - 31884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Murphy, M. S. Moore, G. Drivas, P. P. de la Ossa, A. Villamarin, P. D'Eustachio, and M. G. Rush A T42A Ran Mutation: Differential Interactions with Effectors and Regulators, and Defect in Nuclear Protein Import Mol. Biol. Cell, December 1, 1997; 8(12): 2591 - 2604. [Abstract] [Full Text]
|
|
|
|
|
|
F. Nicolas, C Zhang, M Hughes, M Goldberg, S Watton, and P Clarke Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts J. Cell Sci., January 12, 1997; 110(24): 3019 - 3030. [Abstract] [PDF]
|
|
|
|
|
|
A Battistoni, G Guarguaglini, F Degrassi, C Pittoggi, A Palena, G Di Matteo, C Pisano, E Cundari, and P Lavia Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts J. Cell Sci., January 10, 1997; 110(19): 2345 - 2357. [Abstract] [PDF]
|
|
|
|
|
|
B. M. A. Fontoura, G. Blobel, and N. R. Yaseen The Nucleoporin Nup98 Is a Site for GDP/GTP Exchange on Ran and Termination of Karyopherin beta 2-mediated Nuclear Import J. Biol. Chem., September 29, 2000; 275(40): 31289 - 31296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Radtke, D. Schmalz, E. Coutavas, T. M. Soliman, and R. Peters Kinetics of protein import into isolated Xenopus oocyte nuclei PNAS, February 27, 2001; 98(5): 2407 - 2412. [Abstract] [Full Text] [PDF]
|
|
