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Journal of Cell Science, Vol 109, Issue 10 2551-2560, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
W Kedzierski, WN Moghrabi, AC Allen, MM Jablonski-Stiemke, SM Azarian, D Bok and GH Travis
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9111, USA.
We have isolated and characterized three homologs of mammalian rds/peripherin from Xenopus retinae. One (xrds38) is likely the Xenopus ortholog, while the other two (xrds36 and -35) are more distant relatives. By immunocytochemical analysis of retinal sections, xrds38 is distributed in both rod and cone photoreceptors, while xrds36 and xrds35 are present in rods only. At the EM level, xrds38 is present specifically in the rims and incisures of rod and cone outer segment discs. All are N-glycosylated and form covalent dimers. Immunoprecipitation analysis showed that in rods, these three proteins interact to form heterotetrameric or higher-order complexes. The pattern of sequence conservation among the xrds proteins, mammalian rds/peripherin, and mammalian rom-1 suggest that the central portion of the intradiscal D2 loop contains the interacting structural elements.
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C. J.R. Loewen, O. L. Moritz, B. M. Tam, D. S. Papermaster, and R. S. Molday The Role of Subunit Assembly in Peripherin-2 Targeting to Rod Photoreceptor Disk Membranes and Retinitis Pigmentosa Mol. Biol. Cell, August 1, 2003; 14(8): 3400 - 3413. [Abstract] [Full Text] [PDF]
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C. Li, X.-Q. Ding, J. O'Brien, M. R. Al-Ubaidi, and M. I. Naash Molecular Characterization of the Skate Peripherin/rds Gene: Relationship to Its Orthologues and Paralogues Invest. Ophthalmol. Vis. Sci., June 1, 2003; 44(6): 2433 - 2441. [Abstract] [Full Text] [PDF]
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A. F. X. Goldberg, L. M. Fales, J. B. Hurley, and N. Khattree Folding and Subunit Assembly of Photoreceptor Peripherin/rds Is Mediated by Determinants within the Extracellular/Intradiskal EC2 Domain. IMPLICATIONS FOR HETEROGENEOUS MOLECULAR PATHOLOGIES J. Biol. Chem., November 9, 2001; 276(46): 42700 - 42706. [Abstract] [Full Text] [PDF]
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C. J. R. Loewen and R. S. Molday Disulfide-mediated Oligomerization of Peripherin/Rds and Rom-1 in Photoreceptor Disk Membranes. IMPLICATIONS FOR PHOTORECEPTOR OUTER SEGMENT MORPHOGENESIS AND DEGENERATION J. Biol. Chem., February 25, 2000; 275(8): 5370 - 5378. [Abstract] [Full Text] [PDF]
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 W. Kedzierski, D. Bok, and G. H. Travis Non-Cell-Autonomous Photoreceptor Degeneration in rds Mutant Mice Mosaic for Expression of a Rescue Transgene J. Neurosci., June 1, 1998; 18(11): 4076 - 4082. [Abstract] [Full Text] [PDF]
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