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Journal of Cell Science, Vol 109, Issue 11 2609-2611, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

Protocadherins and diversity of the cadherin superfamily

ST Suzuki
Doheny Eye Institute, University of Southern California School of Medicine, Los Angeles 90033, USA.

Recent cadherin studies have revealed that many cadherins and cadherin-related proteins are expressed in various tissues of different multicellular organisms. These proteins are characterized by the multiple repeats of the cadherin motif in their extracellular domains. The members of the cadherin superfamily are divided into two groups: classical cadherin type and protocadherin type. The current cadherins appear to have evolved from a protocadherin type. Recent studies have proved the cell adhesion role of classical cadherins in embryogenesis. In contrast, the biological role of protocadherins is elusive. Circumstantial evidence, however, suggests that protocadherins are involved in a variety of cell-cell interactions. Since protocadherins, and many other new cadherins as well, have unique properties, studies of these cadherins may provide insight into the structure and biological role of the cadherin superfamily.
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© The Company of Biologists Ltd 1996