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Journal of Cell Science, Vol 109, Issue 11 2737-2745, Copyright © 1996 by Company of Biologists

JOURNAL ARTICLES

NRD convertase: a putative processing endoprotease associated with the axoneme and the manchette in late spermatids

V Chesneau, A Prat, D Segretain, V Hospital, A Dupaix, T Foulon, B Jegou and P Cohen
Laboratoire de Biochimie des Signaux Regulateurs Cellulaires et Moleculaires, Universite Pierre et Marie Curie, Paris, France.

N-arginine dibasic convertase is a novel metalloendopeptidase which selectively cleaves at the N terminus of arginine residues in paired basic amino acids. Although present in brain and several other tissues, NRD convertase is particularly abundant in testis, where its expression appeared to be restricted to germ cells. Low levels of both mRNA and its corresponding protein were detected early in spermatogenesis. However, a marked accumulation of the protein was observed during late steps (14 to 19) of spermiogenesis. By electron microscopy, the NRD convertase immunoreactivity was localized in the cytoplasm of elongating and elongated spermatids, with a noticeable concentration at the level of two microtubular structures, i.e. the manchette and the axoneme. These observations strongly support the hypothesis that NRD convertase is involved in processing events potentially associated with the morphological transformations occurring during spermiogenesis.
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© The Company of Biologists Ltd 1996