|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 109, Issue 2 437-445, Copyright © 1996 by Company of Biologists
JOURNAL ARTICLES |
CD Buckley, R Doyonnas, JP Newton, SD Blystone, EJ Brown, SM Watt and DL Simmons
Cell Adhesion Laboratory, Imperial Cancer Research Fund, John Radcliffe Hospital, Oxford, UK.
CD31 (PECAM-1) is a member of the immunoglobulin gene superfamily (IgSF) and has an important role in a number of endothelial cell functions including angiogenesis, inflammation, integrin activation and cell-cell adhesion. CD31 has both homotypic and heterotypic adhesive properties and in common with other IgSF members contains multiple functional domains. Using chimaeric fusion proteins of CD31 and a panel of haematopoietic cell lines we show that CD31 can bind cells in a predominantly homotypic or heterotypic manner depending on the cell line used. Heterotypic binding was found to be cation and temperature dependent and enhanced by Mn2+: all features of integrin mediated binding. Using a panel of anti-CD31 and anti-integrin antibodies we show that alpha v beta 3 is a ligand for CD31 on the monocytic cell line U937. The specificity of the interaction between alpha v beta 3 and CD31 was further confirmed by solid phase binding assays and the use of alpha v beta 3 transfected cells which bound CD31 specifically. Furthermore, we have mapped the binding site for alpha v beta 3 to domains 1 and 2 of CD31. The interaction of CD31 with alpha v beta 3 may be important in many aspects of endothelial function including leukocyte-endothelial transmigration and angiogenesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Feng, N. P. McCabe, G. H. Mahabeleshwar, P. R. Somanath, D. R. Phillips, and T. V. Byzova The angiogenic response is dictated by {beta}3 integrin on bone marrow-derived cells J. Cell Biol., December 15, 2008; 183(6): 1145 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Woodfin, M.-B. Voisin, and S. Nourshargh PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology Arterioscler. Thromb. Vasc. Biol., December 1, 2007; 27(12): 2514 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Vernon-Wilson, F. Aurade, L. Tian, I. C. M. Rowe, M. J. Shipston, J. Savill, and S. B. Brown CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells J. Leukoc. Biol., November 1, 2007; 82(5): 1278 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Chidlow Jr., D. Shukla, M. B. Grisham, and C. G. Kevil Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G5 - G18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kondo, E. A. Scheef, N. Sheibani, and C. M. Sorenson PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2070 - C2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. F. Vernon-Wilson, F. Aurade, and S. B. Brown CD31 promotes {beta}1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin J. Leukoc. Biol., June 1, 2006; 79(6): 1260 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein, E. E. Schoenbaum, T. M. Calderon, and J. W. Berman Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. J. Leukoc. Biol., March 1, 2006; 79(3): 444 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Falati, S. Patil, P. L. Gross, M. Stapleton, G. Merrill-Skoloff, N. E. Barrett, K. L. Pixton, H. Weiler, B. Cooley, D. K. Newman, et al. Platelet PECAM-1 inhibits thrombus formation in vivo Blood, January 15, 2006; 107(2): 535 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gibbins Platelet adhesion signalling and the regulation of thrombus formation J. Cell Sci., July 15, 2004; 117(16): 3415 - 3425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Righi, S. Deaglio, C. Pecchioni, A. Gregorini, A. L. Horenstein, G. Bussolati, A. Sapino, and F. Malavasi Role of CD31/Platelet Endothelial Cell Adhesion Molecule-1 Expression in in Vitro and in Vivo Growth and Differentiation of Human Breast Cancer Cells Am. J. Pathol., April 1, 2003; 162(4): 1163 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, X. Su, C. M. Sorenson, and N. Sheibani Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H1008 - H1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Davis, M. Sackler, R. I. Brezinschek, E. Lightfoot, J. L. Bailey, N. Oppenheimer-Marks, and P. E. Lipsky Inflammation, Immune Reactivity, and Angiogenesis in a Severe Combined Immunodeficiency Model of Rheumatoid Arthritis Am. J. Pathol., January 1, 2002; 160(1): 357 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cicmil, J. M. Thomas, M. Leduc, C. Bon, and J. M. Gibbins Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets Blood, January 1, 2002; 99(1): 137 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Voura, R. A. Ramjeesingh, A. M.P. Montgomery, and C.-H. Siu Involvement of Integrin alpha vbeta 3 and Cell Adhesion Molecule L1 in Transendothelial Migration of Melanoma Cells Mol. Biol. Cell, September 1, 2001; 12(9): 2699 - 2710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Spring, S. F. Parsons, S. Ortlepp, M. L. Olsson, R. Sessions, R. L. Brady, and D. J. Anstee Intercellular adhesion molecule-4 binds {alpha}4{beta}1 and {alpha}V-family integrins through novel integrin-binding mechanisms Blood, July 15, 2001; 98(2): 458 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Thompson, K. E. Noble, K. Y. Larbi, A. Dewar, G. S. Duncan, T. W. Mak, and S. Nourshargh Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane Blood, March 15, 2001; 97(6): 1854 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Prager, G. Staffler, O. Majdic, M. D. Saemann, S. Godar, G. J. Zlabinger, and H. Stockinger Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells J. Immunol., February 15, 2001; 166(4): 2364 - 2371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zhao and P. J. Newman Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 from Within the Cell J. Cell Biol., January 8, 2001; 152(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Thomas and P.M. Speight Cell Adhesion Molecules and Oral Cancer Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(6): 479 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Zibara, E. Chignier, C. Covacho, R. Poston, G. Canard, P. Hardy, and J. McGregor Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2288 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W.Y. Wong, G. Wiedle, C. Ballestrem, B. Wehrle-Haller, S. Etteldorf, M. Bruckner, B. Engelhardt, R. H. Gisler, and B. A. Imhof PECAM-1/CD31 Trans-homophilic Binding at the Intercellular Junctions Is Independent of Its Cytoplasmic Domain; Evidence for Heterophilic Interaction with Integrin alpha vbeta 3 in Cis Mol. Biol. Cell, September 1, 2000; 11(9): 3109 - 3121. [Abstract] [Full Text]
|
|
|
|
|
|
S. Mahooti, D. Graesser, S. Patil, P. Newman, G. Duncan, T. Mak, and J. A. Madri PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo Am. J. Pathol., July 1, 2000; 157(1): 75 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Thompson, M. W. Wakelin, K. Y. Larbi, A. Dewar, G. Asimakopoulos, M. A. Horton, M. T. Nakada, and S. Nourshargh Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and {beta}3 Integrin Blockade on Leukocyte Transmigration In Vivo J. Immunol., July 1, 2000; 165(1): 426 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Botella, A. Puig-Kroger, N. Almendro, T. Sanchez-Elsner, E. Munoz, A. Corbi, and C. Bernabeu Identification of a Functional NF-{kappa}B Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter J. Immunol., February 1, 2000; 164(3): 1372 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Johnson-Leger, M Aurrand-Lions, and B. Imhof The parting of the endothelium: miracle, or simply a junctional affair? J. Cell Sci., January 3, 2000; 113(6): 921 - 933. [Abstract] [PDF]
|
|
|
|
|
|
M. T. Nakada, K. Amin, M. Christofidou-Solomidou, C. D. O'Brien, J. Sun, I. Gurubhagavatula, G. A. Heavner, A. H. Taylor, C. Paddock, Q.-H. Sun, et al. Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment J. Immunol., January 1, 2000; 164(1): 452 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Wiedle, C. Johnson-Leger, and B. A. Imhof A Chimeric Cell Adhesion Molecule Mediates Homing of Lymphocytes to Vascularized Tumors Cancer Res., October 1, 1999; 59(20): 5255 - 5263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chiba, N. Nakagawa, K. Kurasawa, Y. Tanaka, Y. Saito, and I. Iwamoto Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells Blood, August 15, 1999; 94(4): 1319 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Morales, A. Christ, S. M. Watt, H. S. Kim, K. W. Johnson, N. Utku, A. M. Texieira, A. Mizoguchi, E. Mizoguchi, G. J. Russell, et al. Regulation of Human Intestinal Intraepithelial Lymphocyte Cytolytic Function by Biliary Glycoprotein (CD66a) J. Immunol., August 1, 1999; 163(3): 1363 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schneider, T. B. Issekutz, and A. C. Issekutz The Role of alpha 4 (CD49d) and beta 2 (CD18) Integrins in Eosinophil and Neutrophil Migration to Allergic Lung Inflammation in the Brown Norway Rat Am. J. Respir. Cell Mol. Biol., March 1, 1999; 20(3): 448 - 457. [Abstract] [Full Text]
|
|
|
|
|
|
S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar Irradiation Induces Upregulation of CD31 in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 588 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Rainger, C. D. Buckley, D. L. Simmons, and G. B. Nash Neutrophils sense flow-generated stress and direct their migration through alpha Vbeta 3-integrin Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H858 - H864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Duncan, D. P. Andrew, H. Takimoto, S. A. Kaufman, H. Yoshida, J. Spellberg, J. Luis de la Pompa, A. Elia, A. Wakeham, B. Karan-Tamir, et al. Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions J. Immunol., March 1, 1999; 162(5): 3022 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hermann, M. Armant, E. Brown, M. Rubio, H. Ishihara, D. Ulrich, R.G. Caspary, F.P. Lindberg, R. Armitage, C. Maliszewski, et al. The Vitronectin Receptor and its Associated CD47 Molecule Mediates Proinflammatory Cytokine Synthesis in Human Monocytes by Interaction with Soluble CD23 J. Cell Biol., February 22, 1999; 144(4): 767 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bird, V Taylor, J. Newton, J. Spragg, D. Simmons, M Salmon, and C. Buckley Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration J. Cell Sci., January 6, 1999; 112(12): 1989 - 1997. [Abstract] [PDF]
|
|
|
|
|
|
D Nath, P. Slocombe, P. Stephens, A Warn, G. Hutchinson, K. Yamada, A. Docherty, and G Murphy Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells J. Cell Sci., January 2, 1999; 112(4): 579 - 587. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Riesbeck, A. Billström, J. Tordsson, T. Brodin, K. Kristensson, and M. Dohlsten Endothelial Cells Expressing an Inflammatory Phenotype Are Lysed by Superantigen-Targeted Cytotoxic T Cells Clin. Vaccine Immunol., September 1, 1998; 5(5): 675 - 682. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Watt, H.-J. Buhring, I. Rappold, J. Y.-H. Chan, J. Lee-Prudhoe, T. Jones, A. C.W. Zannettino, P. J. Simmons, R. Doyonnas, D. Sheer, et al. CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21 Blood, August 1, 1998; 92(3): 849 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Weerasinghe, K. P. McHugh, F. P. Ross, E. J. Brown, R. H. Gisler, and B. A. Imhof A Role for the alpha vbeta 3 Integrin in the Transmigration of Monocytes J. Cell Biol., July 27, 1998; 142(2): 595 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Cao, M. Huber, N. Beauchemin, J. Famiglietti, S. M. Albelda, and A. Veillette Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases J. Biol. Chem., June 19, 1998; 273(25): 15765 - 15772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-H. Sun, C. Paddock, G. P. Visentin, M. M. Zukowski, W. A. Muller, and P. J. Newman Cell Surface Glycosaminoglycans Do Not Serve as Ligands for PECAM-1. PECAM-1 IS NOT A HEPARIN-BINDING PROTEIN J. Biol. Chem., May 8, 1998; 273(19): 11483 - 11490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sheibani and W. A. Frazier Down-Regulation of Platelet Endothelial Cell Adhesion Molecule-1 Results in Thrombospondin-1 Expression and Concerted Regulation of Endothelial Cell Phenotype Mol. Biol. Cell, April 1, 1998; 9(4): 701 - 713. [Abstract] [Full Text]
|
|
|
|
|
|
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets Blood, January 15, 1998; 91(2): 500 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Boissy, I Machuca, M Pfaff, D Ficheux, and P Jurdic Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells J. Cell Sci., January 9, 1998; 111(17): 2563 - 2574. [Abstract] [PDF]
|
|
|
|
|
|
S. Deaglio, M. Morra, R. Mallone, C. M. Ausiello, E. Prager, G. Garbarino, U. Dianzani, H. Stockinger, and F. Malavasi Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member J. Immunol., January 1, 1998; 160(1): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity J. Cell Biol., September 22, 1997; 138(6): 1425 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31 J. Biol. Chem., August 15, 1997; 272(33): 20555 - 20563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Liao, J. Ali, T. Greene, and W. A. Muller Soluble Domain 1 of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo J. Exp. Med., April 7, 1997; 185(7): 1349 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING J. Biol. Chem., March 14, 1997; 272(11): 6986 - 6993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Martin and J. Sanes Integrins mediate adhesion to agrin and modulate agrin signaling Development, January 10, 1997; 124(19): 3909 - 3917. [Abstract] [PDF]
|
|
|
|
|
|
J. Sun, J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression J. Biol. Chem., August 2, 1996; 271(31): 18561 - 18570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Cunningham, M. P. Arrate, J. M. Rodriguez, R. J. Bjercke, P. Vanderslice, A. P. Morris, and T. A. Brock A Novel Protein with Homology to the Junctional Adhesion Molecule. CHARACTERIZATION OF LEUKOCYTE INTERACTIONS J. Biol. Chem., October 27, 2000; 275(44): 34750 - 34756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cicmil, J. M. Thomas, T. Sage, F. A. Barry, M. Leduc, C. Bon, and J. M. Gibbins Collagen, Convulxin, and Thrombin Stimulate Aggregation-independent Tyrosine Phosphorylation of CD31 in Platelets. EVIDENCE FOR THE INVOLVEMENT OF Src FAMILY KINASES J. Biol. Chem., August 25, 2000; 275(35): 27339 - 27347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cao, C. D. O'Brien, Z. Zhou, S. M. Sanders, J. N. Greenbaum, A. Makrigiannakis, and H. M. DeLisser Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1181 - C1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oka, K. Tagoku, T. L. Russell, Y. Nakano, T. Hamazaki, E. M. Meyer, T. Yokota, and N. Terada CD9 Is Associated with Leukemia Inhibitory Factor-mediated Maintenance of Embryonic Stem Cells Mol. Biol. Cell, April 1, 2002; 13(4): 1274 - 1281. [Abstract] [Full Text] [PDF]
|
|
