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Journal of Cell Science, Vol 11, 777-784, Copyright © 1972 by Company of Biologists

Deoxythymidine Metabolism in Avian Erythroid Cells

A. F. WILLIAMS 1

1 Department of Biochemistry, University of Adelaide, Australia; Department of Biochemistry, University of Oxford, England

The ability of dividing and non-dividing cells of the avian erythropoietic series to phosphorylate [3H] deoxythymidine and [3H]uridine has been studied. Enzyme levels of deoxythymidine kinase were also assayed. Both dividing and immature non-dividing erythroid cells phosphorylated uridine to uridine triphosphate (UTP). However, only cells able to synthesize DNA could phosphorylate deoxythymidine to the triphosphate; also these cells were the only ones to show detectable deoxythymidine kinase activities.






© The Company of Biologists Ltd 1972