spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackson, D.
Right arrow Articles by Dickson, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, D.
Right arrow Articles by Dickson, C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 110, Issue 11 1261-1268, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland

D Jackson, J Bresnick, I Rosewell, T Crafton, R Poulsom, G Stamp and C Dickson
Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund, London, UK.

We have used the mouse mammary tumor virus promoter to express two dominant negative (DN) fibroblast growth factor receptor (FGFR) isoforms in the mammary epithelium of transgenic mice. While expression of DN-FGFR1(IIIc) showed no discernible phenotype, a similar kinase negative form of FGFR2(IIIb) caused a marked impairment of lobuloalveolar development. The growth retardation was apparent by mid-pregnancy and persisted in the post-partum glands. Despite the substantial underdevelopment of the mammary gland there was a measurable lactational response, but it was insufficient to properly sustain the new-born pups. These findings demonstrate that fibroblast growth factor signalling is necessary for pregnancy dependent lobuloalveolar development of the mammary gland.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
T. B. Deramaudt, M. Takaoka, R. Upadhyay, M. J. Bowser, J. Porter, A. Lee, B. Rhoades, C. N. Johnstone, R. Weissleder, S. R. Hingorani, et al.
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption
Mol. Cell. Biol., June 1, 2006; 26(11): 4185 - 4200.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. L. Schwertfeger, J. L. McManaman, C. A. Palmer, M. C. Neville, and S. M. Anderson
Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation
J. Lipid Res., June 1, 2003; 44(6): 1100 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Kohl, M. Antoine, K. Reimers, and P. Kiefer
FGF3 Attached to a Phosholipid Membrane Anchor Gains a High Transforming Capacity. IMPLICATIONS OF MICRODOMAINS FOR FGF3 CELL TRANSFORMATION
J. Biol. Chem., August 30, 2002; 277(36): 32760 - 32767.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
B. E. Welm, K. W. Freeman, M. Chen, A. Contreras, D. M. Spencer, and J. M. Rosen
Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland
J. Cell Biol., May 13, 2002; 157(4): 703 - 714.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S Naylor, M. Smalley, D Robertson, B. Gusterson, P. Edwards, and T. Dale
Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium
J. Cell Sci., January 6, 2000; 113(12): 2129 - 2138.
[Abstract] [PDF]

Home page
 DevelopmentHome page
L De Moerlooze, B Spencer-Dene, J Revest, M Hajihosseini, I Rosewell, and C Dickson
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
Development, January 2, 2000; 127(3): 483 - 492.
[Abstract] [PDF]

Home page
 ScienceHome page
R. J. Metzger and M. A. Krasnow
Genetic Control of Branching Morphogenesis
Science, June 4, 1999; 284(5420): 1635 - 1639.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
T. N. Seagroves, S. Krnacik, B. Raught, J. Gay, B. Burgess-Beusse, G. J. Darlington, and J. M. Rosen
C/EBPbeta , but not C/EBPalpha , is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland
Genes & Dev., June 15, 1998; 12(12): 1917 - 1928.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
V. K. Pedchenko and W. T. Imagawa
Mammogenic Hormones Differentially Modulate Keratinocyte Growth Factor (KGF)-Induced Proliferation and KGF Receptor Expression in Cultured Mouse Mammary Gland Epithelium
Endocrinology, May 1, 1998; 139(5): 2519 - 2526.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Lametsch, J. T. Rasmussen, L. B. Johnsen, S. Purup, K. Sejrsen, T. E. Petersen, and C. W. Heegaard
Structural Characterization of the Fibroblast Growth Factor-binding Protein Purified from Bovine Prepartum Mammary Gland Secretion
J. Biol. Chem., June 23, 2000; 275(26): 19469 - 19474.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1997