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Journal of Cell Science, Vol 110, Issue 18 2207-2214, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
MH Delgrossi, L Breuza, C Mirre, P Chavrier and A Le Bivic
Laboratoire de Genetique et Physiologie du Developpement, Campus de Luminy, Marsaille, France.
To understand the molecular mechanisms underlying sorting of apical and basolateral membrane components in human intestinal epithelial cells, we have cloned the human homolog of rat syntaxin 3 and looked for its subcellular localization. Endogenous human syntaxin 3 was found to be localized at the apical membrane of colon epithelial and Caco-2 cells. This apical localization was confirmed by confocal microscopy after transfection of the cDNA coding for either full length or N-terminally truncated human syntaxin 3 in Caco-2 cells. Furthermore the signal(s) and machinery targeting human syntaxin 3 to the apical membrane of epithelial cells are conserved between species since human syntaxin 3 was also localized at the apical membrane of canine MDCK cells and of epithelial cells in transgenic Drosophila melanogaster.
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