|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 110, Issue 23 2895-2904, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
C Brakebusch, E Hirsch, A Potocnik and R Fassler
Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany.
Integrins are heterodimeric cell adhesion proteins connecting the extracellular matrix to the cytoskeleton and transmitting signals in both directions. These integrins are suggested to be involved in many different biological processes such as growth, differentiation, migration, and cell death. Of more than 20 known integrins, 10 contain the nearly ubiquitously expressed beta1 integrin subunit. Disruption of the beta1 integrin gene by homologous recombination allows us to assess the supposed functions of beta1 containing integrins in vivo in a new way. This review will present and discuss recent findings derived from such studies concerning the biological roles of beta1 integrins in early development, differentiation and migration, hematopoiesis, tumorigenesis, and supramolecular assembly of extracellular matrix proteins. While several former results were confirmed, others were contradicted and new functions found, significantly changing the previous view of beta1 integrin function in vivo.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Lei, D. Liu, Y. Huang, I. Jovin, S.-Y. Shai, T. Kyriakides, R. S. Ross, and F. J. Giordano Endothelial Expression of 1 Integrin Is Required for Embryonic Vascular Patterning and Postnatal Vascular Remodeling Mol. Cell. Biol., January 15, 2008; 28(2): 794 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Pylayeva and F. G. Giancotti Development requires activation but not phosphorylation of beta1 integrins. Genes & Dev., May 1, 2006; 20(9): 1057 - 1060. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Hirsch, L. Barberis, M. Brancaccio, O. Azzolino, D. Xu, J. M. Kyriakis, L. Silengo, F. G. Giancotti, G. Tarone, R. Fassler, et al. Defective Rac-mediated proliferation and survival after targeted mutation of the {beta}1 integrin cytodomain J. Cell Biol., April 29, 2002; 157(3): 481 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Mueller, M. Moser, R. Kluge, S. Leder, M. Blum, R. Buttner, H.-G. Joost, and A. Schurmann Embryonic Lethality Caused by Apoptosis during Gastrulation in Mice Lacking the Gene of the ADP-Ribosylation Factor-Related Protein 1 Mol. Cell. Biol., March 1, 2002; 22(5): 1488 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gustavsson, A. Armulik, C. Brakebusch, R. Fassler, S. Johansson, and M. Fallman Role of the {beta}1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia J. Cell Sci., January 7, 2002; 115(13): 2669 - 2678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Grose, C. Hutter, W. Bloch, I. Thorey, F. M. Watt, R. Fassler, C. Brakebusch, and S. Werner A crucial role of {beta}1 integrins for keratinocyte migration in vitro and during cutaneous wound repair Development, January 5, 2002; 129(9): 2303 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Retta, G. Cassara, M. D'Amato, R. Alessandro, M. Pellegrino, S. Degani, G. De Leo, L. Silengo, and G. Tarone Cross Talk between beta 1 and alpha V Integrins: beta 1 Affects beta 3 mRNA Stability Mol. Biol. Cell, October 1, 2001; 12(10): 3126 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Bouvard, C. Brakebusch, E. Gustafsson, A. Aszodi, T. Bengtsson, A. Berna, and R. Fassler Functional Consequences of Integrin Gene Mutations in Mice Circ. Res., July 30, 2001; 89(3): 211 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Werr, E. E. Eriksson, P. Hedqvist, and L. Lindbom Engagement of {beta}2 integrins induces surface expression of {beta}1 integrin receptors in human neutrophils J. Leukoc. Biol., October 1, 2000; 68(4): 553 - 560. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Häkkinen, H. C. Hildebrand, A. Berndt, H. Kosmehl, and H. Larjava Immunolocalization of Tenascin-C, {alpha}9 Integrin Subunit, and {alpha}v{beta}6 Integrin During Wound Healing in Human Oral Mucosa J. Histochem. Cytochem., July 1, 2000; 48(7): 985 - 998. [Abstract] [Full Text]
|
|
|
|
|
|
M. Martin-Bermudo and N. Brown The localized assembly of extracellular matrix integrin ligands requires cell-cell contact J. Cell Sci., January 11, 2000; 113(21): 3715 - 3723. [Abstract] [PDF]
|
|
|
|
|
|
M. Martin-Bermudo Integrins modulate the Egfr signaling pathway to regulate tendon cell differentiation in the Drosophila embryo Development, January 6, 2000; 127(12): 2607 - 2615. [Abstract] [PDF]
|
|
|
|
|
|
J. Li, R. Mayne, and C. Wu A Novel Muscle-specific {beta}1 Integrin Binding Protein (MIBP) that Modulates Myogenic Differentiation J. Cell Biol., December 27, 1999; 147(7): 1391 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gimond, A. van der Flier, S. van Delft, C. Brakebusch, I. Kuikman, J. G. Collard, R. Fassler, and A. Sonnenberg Induction of Cell Scattering by Expression of {beta}1 Integrins in {beta}1-deficient Epithelial Cells Requires Activation of Members of the Rho Family of GTPases and Downregulation of Cadherin and Catenin Function J. Cell Biol., December 13, 1999; 147(6): 1325 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Spirin, A. V. Ljubimov, R. Castellon, O. Wiedoeft, M. Marano, D. Sheppard, M. C. Kenney, and D. J. Brown Analysis of Gene Expression in Human Bullous Keratopathy Corneas Containing Limiting Amounts of RNA Invest. Ophthalmol. Vis. Sci., December 1, 1999; 40(13): 3108 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Martin-Bermudo and N. H. Brown Uncoupling integrin adhesion and signaling: the beta PS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo Genes & Dev., March 15, 1999; 13(6): 729 - 739. [Abstract] [Full Text]
|
|
|
|
|
|
J Madruga, N. Koritschoner, S. Diebold, S. Kurz, and M Zenke Polarised expression pattern of focal contact proteins in highly motile antigen presenting dendritic cells J. Cell Sci., January 6, 1999; 112(11): 1685 - 1696. [Abstract] [PDF]
|
|
|
|
|
|
R Anderson, R Fassler, E Georges-Labouesse, R. Hynes, B. Bader, J. Kreidberg, K Schaible, J Heasman, and C Wylie Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads Development, January 4, 1999; 126(8): 1655 - 1664. [Abstract] [PDF]
|
|
|
|
|
|
D. Taverna, M.-H. Disatnik, H. Rayburn, R. T. Bronson, J. Yang, T. A. Rando, and R. O. Hynes Dystrophic Muscle in Mice Chimeric for Expression of alpha 5 Integrin J. Cell Biol., November 2, 1998; 143(3): 849 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fornaro, M. Manzotti, G. Tallini, A. E. Slear, S. Bosari, E. Ruoslahti, and L. R. Languino ß1C Integrin in Epithelial Cells Correlates with a Nonproliferative Phenotype : Forced Expression of ß1C Inhibits ProstateEpithelial Cell Proliferation Am. J. Pathol., October 1, 1998; 153(4): 1079 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hirsch, L. Barberis, M. Brancaccio, O. Azzolino, D. Xu, J. M. Kyriakis, L. Silengo, F. G. Giancotti, G. Tarone, R. Fassler, et al. Defective Rac-mediated proliferation and survival after targeted mutation of the {beta}1 integrin cytodomain J. Cell Biol., April 29, 2002; 157(3): 481 - 492. [Abstract] [Full Text] [PDF]
|
|
