Journal of Cell Science, Vol 110, Issue 24 3001-3009, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Post-Golgi biosynthetic trafficking

P Keller and K Simons
European Molecular Biology Laboratory, Cell Biology Programme, D-69012 Heidelberg, Germany. Keller@embl-heidelberg.de

Eukaryotic cells have developed complex machineries to distribute proteins and lipids from the Golgi complex. Contrary to what has originally been postulated, delivery of proteins to the cell surface is not a simple bulk flow process but involves sorting into distinct pathways from the trans-Golgi network. Here we describe the various routes emerging from the trans-Golgi network in different cell types, and we discuss the mechanisms that mediate sorting into these pathways. While much remains to be learned about these sorting mechanisms, it is apparent that a number of pathways previously believed to be restricted to certain cell types might be used more commonly.
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				D Toomre, P Keller, J White, J. Olivo, and K Simons Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells J. Cell Sci., January 1, 1999; 112(1): 21 - 33. [Abstract] [PDF]

				C. YEAMAN, K. K. GRINDSTAFF, and W. J. NELSON New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity Physiol Rev, January 1, 1999; 79(1): 73 - 98. [Abstract] [Full Text] [PDF]

				A. Gut, M. S. Balda, and K. Matter The Cytoplasmic Domains of a beta 1 Integrin Mediate Polarization in Madin-Darby Canine Kidney Cells by Selective Basolateral Stabilization J. Biol. Chem., November 6, 1998; 273(45): 29381 - 29388. [Abstract] [Full Text] [PDF]

				S. S. Molloy, L. Thomas, C. Kamibayashi, M. C. Mumby, and G. Thomas Regulation of Endosome Sorting by a Specific PP2A Isoform J. Cell Biol., September 21, 1998; 142(6): 1399 - 1411. [Abstract] [Full Text] [PDF]

				H. Takatsu, M. Sakurai, H.-W. Shin, K. Murakami, and K. Nakayama Identification and Characterization of Novel Clathrin Adaptor-related Proteins J. Biol. Chem., September 18, 1998; 273(38): 24693 - 24700. [Abstract] [Full Text] [PDF]

				F. P. Finger and P. Novick Spatial Regulation of Exocytosis: Lessons from Yeast J. Cell Biol., August 10, 1998; 142(3): 609 - 612. [Full Text] [PDF]

				A. D. Marmorstein, Y. C. Gan, V. L. Bonilha, S. C. Finnemann, K. G. Csaky, and E. Rodriguez-Boulan Apical Polarity of N-CAM and EMMPRIN in Retinal Pigment Epithelium Resulting from Suppression of Basolateral Signal Recognition J. Cell Biol., August 10, 1998; 142(3): 697 - 710. [Abstract] [Full Text] [PDF]