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Journal of Cell Science, Vol 110, Issue 3 369-378, Copyright © 1997 by Company of Biologists
JOURNAL ARTICLES |
F Arenzana-Seisdedos, P Turpin, M Rodriguez, D Thomas, RT Hay, JL Virelizier and C Dargemont
Unite d'Immunologie Virale, Institut Pasteur, Paris, France.
I kappa B alpha tightly regulates the transcriptional activity of NF-kappa B by retaining it in the cytoplasm in an inactive form. In the present work, we report that I kappa B alpha, when expressed in the nuclear compartment, not only abrogates NF-kappa B/DNA interactions and NF-kappa B-dependent transcription, but also transports NF-kappa B back to the cytoplasm. This function of I kappa B alpha is insured by a nuclear export sequence located in the C-terminal domain of I kappa B alpha and homologous to the previously described export signal found in HIV-1 Rev protein as well as in PKI (the inhibitor of the catalytic subunit of protein kinase A). Thus, inhibition of NF-kappa B/DNA binding and the consecutive efficient nuclear export of the transcription factor of I kappa B alpha could represent an important mechanism for the control of the expression of NF-kappa B-dependent genes.
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R. Weil, H. Sirma, C. Giannini, D. Kremsdorf, C. Bessia, C. Dargemont, C. Brechot, and A. Israel Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-kappa B Inhibitor Ikappa Balpha Mol. Cell. Biol., September 1, 1999; 19(9): 6345 - 6354. [Abstract] [Full Text] [PDF]
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D. Elewaut, J. A. DiDonato, J. Mogg Kim, F. Truong, L. Eckmann, and M. F. Kagnoff NF-{kappa}B Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria J. Immunol., August 1, 1999; 163(3): 1457 - 1466. [Abstract] [Full Text] [PDF]
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M. Floer and G. Blobel Putative Reaction Intermediates in Crm1-mediated Nuclear Protein Export J. Biol. Chem., June 4, 1999; 274(23): 16279 - 16286. [Abstract] [Full Text] [PDF]
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N. Kudo, H. Taoka, T. Toda, M. Yoshida, and S. Horinouchi A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1 J. Biol. Chem., May 21, 1999; 274(21): 15151 - 15158. [Abstract] [Full Text] [PDF]
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C. H. Selzman, B. D. Shames, L. L. Reznikov, S. A. Miller, X. Meng, H. A. Barton, A. Werman, A. H. Harken, C. A. Dinarello, and A. Banerjee Liposomal Delivery of Purified Inhibitory-{kappa}B{alpha} Inhibits Tumor Necrosis Factor-{alpha}–Induced Human Vascular Smooth Muscle Proliferation Circ. Res., April 30, 1999; 84(8): 867 - 875. [Abstract] [Full Text] [PDF]
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M. S. Rodriguez, J. Thompson, R. T. Hay, and C. Dargemont Nuclear Retention of Ikappa Balpha Protects It from Signal-induced Degradation and Inhibits Nuclear Factor kappa B Transcriptional Activation J. Biol. Chem., March 26, 1999; 274(13): 9108 - 9115. [Abstract] [Full Text] [PDF]
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P. Turpin, R. T. Hay, and C. Dargemont Characterization of Ikappa Balpha Nuclear Import Pathway J. Biol. Chem., March 5, 1999; 274(10): 6804 - 6812. [Abstract] [Full Text] [PDF]
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O Rosorius, B Reichart, F Kratzer, P Heger, M. Dabauvalle, and J Hauber Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1 J. Cell Sci., January 7, 1999; 112(14): 2369 - 2380. [Abstract] [PDF]
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 A Maizel, O Bensaude, A Prochiantz, and A Joliot A short region of its homeodomain is necessary for engrailed nuclear export and secretion Development, January 6, 1999; 126(14): 3183 - 3190. [Abstract] [PDF]
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S. Simeonidis, D. Stauber, G. Chen, W. A. Hendrickson, and D. Thanos Mechanisms by which Ikappa B proteins control NF-kappa B activity PNAS, January 5, 1999; 96(1): 49 - 54. [Abstract] [Full Text] [PDF]
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 T. HUXFORD, S. MALEK, and G. GHOSH Structure and Mechanism in NF-{kappa}B/I{kappa}B Signaling Cold Spring Harb Symp Quant Biol, January 1, 1999; 64(0): 533 - 540. [Abstract] [PDF]
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R. K. Tyagi, L. Amazit, P. Lescop, E. Milgrom, and A. Guiochon-Mantel Mechanisms of Progesterone Receptor Export from Nuclei: Role of Nuclear Localization Signal, Nuclear Export Signal, and Ran Guanosine Triphosphate Mol. Endocrinol., November 1, 1998; 12(11): 1684 - 1695. [Abstract] [Full Text]
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S. Sachdev and M. Hannink Loss of Ikappa Balpha -Mediated Control over Nuclear Import and DNA Binding Enables Oncogenic Activation of c-Rel Mol. Cell. Biol., September 1, 1998; 18(9): 5445 - 5456. [Abstract] [Full Text]
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L. Liu, Y.-T. Kwak, F. Bex, L. F. García-Martínez, X.-H. Li, K. Meek, W. S. Lane, and R. B. Gaynor DNA-Dependent Protein Kinase Phosphorylation of Ikappa Balpha and Ikappa Bbeta Regulates NF-kappa B DNA Binding Properties Mol. Cell. Biol., July 1, 1998; 18(7): 4221 - 4234. [Abstract] [Full Text]
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 B. D. Shames, C. H. Selzman, X. Meng, D. R. Meldrum, B. S. Cain, and A. H. Harken Genes Don't Count Arch Surg, June 1, 1998; 133(6): 667 - 669. [Abstract] [Full Text] [PDF]
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S. Sachdev, A. Hoffmann, and M. Hannink Nuclear Localization of Ikappa Balpha Is Mediated by the Second Ankyrin Repeat: the Ikappa Balpha Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences Mol. Cell. Biol., May 1, 1998; 18(5): 2524 - 2534. [Abstract] [Full Text]
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I. Luque and C. Gélinas Distinct Domains of Ikappa Balpha Regulate c-Rel in the Cytoplasm and in the Nucleus Mol. Cell. Biol., March 1, 1998; 18(3): 1213 - 1224. [Abstract] [Full Text]
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F Bachelerie, M. Rodriguez, C Dargemont, D Rousset, D Thomas, J. Virelizier, and F Arenzana-Seisdedos Nuclear export signal of IkappaBalpha interferes with the Rev-dependent posttranscriptional regulation of human immunodeficiency virus type I J. Cell Sci., January 11, 1997; 110(22): 2883 - 2893. [Abstract] [PDF]
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J. A. Schmid, A. Birbach, R. Hofer-Warbinek, M. Pengg, U. Burner, P. G. Furtmuller, B. R. Binder, and R. de Martin Dynamics of NF kappa B and Ikappa Balpha Studied with Green Fluorescent Protein (GFP) Fusion Proteins. INVESTIGATION OF GFP-p65 BINDING TO DNA BY FLUORESCENCE RESONANCE ENERGY TRANSFER J. Biol. Chem., May 26, 2000; 275(22): 17035 - 17042. [Abstract] [Full Text] [PDF]
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M. Prigent, I. Barlat, H. Langen, and C. Dargemont Ikappa Balpha and Ikappa Balpha /NF-kappa B Complexes Are Retained in the Cytoplasm through Interaction with a Novel Partner, RasGAP SH3-binding Protein 2 J. Biol. Chem., November 10, 2000; 275(46): 36441 - 36449. [Abstract] [Full Text] [PDF]
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C. B. Phelps, L. L. Sengchanthalangsy, T. Huxford, and G. Ghosh Mechanism of Ikappa Balpha Binding to NF-kappa B Dimers J. Biol. Chem., September 15, 2000; 275(38): 29840 - 29846. [Abstract] [Full Text] [PDF]
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Z. E. Floyd, J. S. Trausch-Azar, E. Reinstein, A. Ciechanover, and A. L. Schwartz The Nuclear Ubiquitin-Proteasome System Degrades MyoD J. Biol. Chem., June 15, 2001; 276(25): 22468 - 22475. [Abstract] [Full Text] [PDF]
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M. S. Rodriguez, C. Dargemont, and R. T. Hay SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting J. Biol. Chem., April 13, 2001; 276(16): 12654 - 12659. [Abstract] [Full Text] [PDF]
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S.-H. Lee and M. Hannink The N-terminal Nuclear Export Sequence of Ikappa Balpha Is Required for RanGTP-dependent Binding to CRM1 J. Biol. Chem., June 22, 2001; 276(26): 23599 - 23606. [Abstract] [Full Text] [PDF]
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I. Vancurova, V. Miskolci, and D. Davidson NF-kappa B Activation in Tumor Necrosis Factor alpha -stimulated Neutrophils Is Mediated by Protein Kinase Cdelta . CORRELATION TO NUCLEAR Ikappa Balpha J. Biol. Chem., June 1, 2001; 276(23): 19746 - 19752. [Abstract] [Full Text] [PDF]
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