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Journal of Cell Science, Vol 111, Issue 1 1-9, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

RE Brown
The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.

Recent cell biological studies suggest that sphingolipids and cholesterol may cluster in biomembranes to form raft-like microdomains. Such lipid domains are postulated to function as platforms involved in the lateral sorting of certain proteins during their trafficking within cells as well as during signal transduction events. Here, the physical interactions that occur between cholesterol and sphingolipids in model membrane systems are discussed within the context of microdomain formation. A model is presented in which the role of cholesterol is refined compared to earlier models.


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Home page
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[Abstract] [Full Text] [PDF]

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Home page
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Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
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Mol. Biol. Cell, November 1, 2001; 12(11): 3550 - 3562.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
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Physiol Rev, October 1, 2001; 81(4): 1689 - 1723.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
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J. Cell Biol., October 3, 2000; 151(1): 143 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
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J. Exp. Med., October 2, 2000; 192(7): 1047 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
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J. Lipid Res., October 1, 2000; 41(10): 1680 - 1688.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
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