Journal of Cell Science, Vol 111, Issue 19 2831-2839, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Protein transport from the endoplasmic reticulum to the Golgi apparatus

W Hong
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Singapore. mcbhwj@imcb.nus.edu.sg.

As the first step of protein transport along the biosynthetic (secretory/exocytotic) pathway, transport from the endoplasmic reticulum (ER) to the Golgi apparatus has received much attention over the past several decades. The general structural organization underlying this transport process is becoming more defined. The major protein components participating in the budding, pre-docking, and docking/fusion events have been identified and their mechanistic aspects investigated. Conceptually, it is now clear that protein export from the ER is a selective process. Although much remains to be defined or refined, the general picture of this transport step has now emerged.

This article has been cited by other articles:

				D. Williams and J. E. Pessin Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes J. Cell Biol., January 28, 2008; 180(2): 375 - 387. [Abstract] [Full Text] [PDF]

				W. Shimoi, I. Ezawa, K. Nakamoto, S. Uesaki, G. Gabreski, M. Aridor, A. Yamamoto, M. Nagahama, M. Tagaya, and K. Tani p125 Is Localized in Endoplasmic Reticulum Exit Sites and Involved in Their Organization J. Biol. Chem., March 18, 2005; 280(11): 10141 - 10148. [Abstract] [Full Text] [PDF]

				E. Loh, F. Peter, V. N. Subramaniam, and W. Hong Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus J. Cell Sci., March 15, 2005; 118(6): 1209 - 1222. [Abstract] [Full Text] [PDF]

				F. Kano, A. R. Tanaka, S. Yamauchi, H. Kondo, and M. Murata Cdc2 Kinase-dependent Disassembly of Endoplasmic Reticulum (ER) Exit Sites Inhibits ER-to-Golgi Vesicular Transport during Mitosis Mol. Biol. Cell, September 1, 2004; 15(9): 4289 - 4298. [Abstract] [Full Text] [PDF]

				A. C. Horton and M. D. Ehlers Dual Modes of Endoplasmic Reticulum-to-Golgi Transport in Dendrites Revealed by Live-Cell Imaging J. Neurosci., July 16, 2003; 23(15): 6188 - 6199. [Abstract] [Full Text] [PDF]

				Q. Zeng, T. T. H. Tran, H.-X. Tan, and W. Hong The Cytoplasmic Domain of Vamp4 and Vamp5 Is Responsible for Their Correct Subcellular Targeting: THE N-TERMINAL EXTENSION OF VAMP4 CONTAINS A DOMINANT AUTONOMOUS TARGETING SIGNAL FOR THE TRANS-GOLGI NETWORK J. Biol. Chem., June 13, 2003; 278(25): 23046 - 23054. [Abstract] [Full Text] [PDF]

				H. Horstmann, C. P. Ng, B. L. Tang, and W. Hong Ultrastructural characterization of endoplasmic reticulum -- Golgi transport containers (EGTC) J. Cell Sci., November 15, 2002; 115(22): 4263 - 4273. [Abstract] [Full Text] [PDF]

				E. Loh and W. Hong Sec34 Is Implicated in Traffic from the Endoplasmic Reticulum to the Golgi and Exists in a Complex with GTC-90 and ldlBp J. Biol. Chem., June 7, 2002; 277(24): 21955 - 21961. [Abstract] [Full Text] [PDF]

				L. Lu, H. Horstmann, C. Ng, and W. Hong Regulation of Golgi structure and function by ARF-like protein 1 (Arl1) J. Cell Sci., March 14, 2002; 114(24): 4543 - 4555. [Abstract] [Full Text] [PDF]

				B. L. Tang, Y. S. Ong, B. Huang, S. Wei, E. T. Wong, R. Qi, H. Horstmann, and W. Hong A Membrane Protein Enriched in Endoplasmic Reticulum Exit Sites Interacts with COPII J. Biol. Chem., October 19, 2001; 276(43): 40008 - 40017. [Abstract] [Full Text] [PDF]

				J. Monnat, E. M. Neuhaus, M. S. Pop, D. M. Ferrari, B. Kramer, and T. Soldati Identification of a Novel Saturable Endoplasmic Reticulum Localization Mechanism Mediated by the C-Terminus of a Dictyostelium Protein Disulfide Isomerase Mol. Biol. Cell, October 1, 2000; 11(10): 3469 - 3484. [Abstract] [Full Text]

				Nadia Khelef, T. T. Soe, O. Quehenberger, N. Beatini, I. Tabas, and F. R. Maxfield Enrichment of Acyl Coenzyme A:Cholesterol O-Acyltransferase Near Trans-Golgi Network and Endocytic Recycling Compartment Arterioscler. Thromb. Vasc. Biol., July 1, 2000; 20(7): 1769 - 1776. [Abstract] [Full Text] [PDF]

				T. Weber, F. Parlati, J. A. McNew, R. J. Johnston, B. Westermann, T. H. Sollner, and J. E. Rothman SNAREpins Are Functionally Resistant to Disruption by NSF and {alpha}SNAP J. Cell Biol., May 29, 2000; 149(5): 1063 - 1072. [Abstract] [Full Text] [PDF]

				M Ying, T Flatmark, and J Saraste The p58-positive pre-golgi intermediates consist of distinct subpopulations of particles that show differential binding of COPI and COPII coats and contain vacuolar H(+)-ATPase J. Cell Sci., January 10, 2000; 113(20): 3623 - 3638. [Abstract] [PDF]

				H. Hauri, F Kappeler, H Andersson, and C Appenzeller ERGIC-53 and traffic in the secretory pathway J. Cell Sci., January 2, 2000; 113(4): 587 - 596. [Abstract] [PDF]

				C. Alvarez, H. Fujita, A. Hubbard, and E. Sztul ER to Golgi Transport: Requirement for p115 at a Pre-Golgi VTC Stage J. Cell Biol., December 13, 1999; 147(6): 1205 - 1222. [Abstract] [Full Text] [PDF]

				A. J. Crofts, N. Leborgne-Castel, S. Hillmer, D. G. Robinson, B. Phillipson, L. E. Carlsson, D. A. Ashford, and J. Denecke Saturation of the Endoplasmic Reticulum Retention Machinery Reveals Anterograde Bulk Flow PLANT CELL, November 1, 1999; 11(11): 2233 - 2248. [Abstract] [Full Text]

				D Ossipov, S Schroder-Kohne, and H. Schmitt Yeast ER-Golgi v-SNAREs Bos1p and Bet1p differ in steady-state localization and targeting J. Cell Sci., January 11, 1999; 112(22): 4135 - 4142. [Abstract] [PDF]

				K. Hager, B Striepen, L. Tilney, and D. Roos The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii J. Cell Sci., January 8, 1999; 112(16): 2631 - 2638. [Abstract] [PDF]

				T. Funakoshi, S. Yasuda, M. Fukasawa, M. Nishijima, and K. Hanada Reconstitution of ATP- and Cytosol-dependent Transport of de Novo Synthesized Ceramide to the Site of Sphingomyelin Synthesis in Semi-intact Cells J. Biol. Chem., September 22, 2000; 275(39): 29938 - 29945. [Abstract] [Full Text] [PDF]