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Journal of Cell Science, Vol 111, Issue 5 541-547, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
MS Balda and K Matter
Department of Cell Biology, University of Geneva, Geneva, Switzerland. balda@cellbio.unige.ch
Tight junctions are the most apical intercellular junctions of epithelial and endothelial cells and create a regulatable semipermeable diffusion barrier between individual cells. On a cellular level, they form an intramembrane diffusion fence that restricts the intermixing of apical and basolateral membrane components. In addition to these well defined functions, more recent evidence suggests that tight junctions are also involved in basic cellular processes like the regulation of cell growth and differentiation.
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