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Journal of Cell Science, Vol 112, Issue 12 1999-2009, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
JA Deakin and M Lyon
Cancer Research Campaign Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK.
Hepatocyte growth factor interacts with both heparan and dermatan sulphates, in addition to its specific signalling receptor, Met. However, the extent of glycosaminoglycan involvement in its biological activity remains uncertain. We have investigated the effects of exogenous glycosaminoglycan addition upon hepatocyte growth factor-stimulated motility of Madin-Darby canine kidney cells. Exogenous heparan/dermatan sulphate chains behave similarly as either potentiators or inhibitors of cell motility (depending upon the assay). Specific heparan sulphate oligosaccharides, of octasaccharide or larger, elicit similar effects, though with reduced potency. Additionally we have investigated the motility of cells made completely deficient in functional proteoglycans by metabolic inhibition of glycosaminoglycan sulphation, using chlorate. Such cells are completely unresponsive to hepatocyte growth factor, both in terms of downstream phosphorylation of mitogen-activated protein kinase and actual cell motility, though they do remain responsive to phorbol ester. Interestingly, although cell responsiveness to hepatocyte growth factor is not restored by exogenous heparan/dermatan sulphate chains, it is by an immobilised heparan sulphate proteoglycan substratum. These findings suggest that hepatocyte growth factor activity is not only critically dependent upon the presence of glycosaminoglycan, but specifically requires an intact proteoglycan structure located in close apposition to cell surface Met.
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S. Ashikari-Hada, H. Habuchi, Y. Kariya, N. Itoh, A. H. Reddi, and K. Kimata Characterization of Growth Factor-binding Structures in Heparin/Heparan Sulfate Using an Octasaccharide Library J. Biol. Chem., March 26, 2004; 279(13): 12346 - 12354. [Abstract] [Full Text] [PDF]
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A. L. Pollack, G. Apodaca, and K. E. Mostov Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity Am J Physiol Cell Physiol, March 1, 2004; 286(3): C482 - C494. [Abstract] [Full Text]
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M. Delehedde, M. Lyon, R. Vidyasagar, T. J. McDonnell, and D. G. Fernig Hepatocyte Growth Factor/Scatter Factor Binds to Small Heparin-derived Oligosaccharides and Stimulates the Proliferation of Human HaCaT Keratinocytes J. Biol. Chem., March 29, 2002; 277(14): 12456 - 12462. [Abstract] [Full Text] [PDF]
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D. Bechard, T. Gentina, M. Delehedde, A. Scherpereel, M. Lyon, M. Aumercier, R. Vazeux, C. Richet, P. Degand, B. Jude, et al. Endocan Is a Novel Chondroitin Sulfate/Dermatan Sulfate Proteoglycan That Promotes Hepatocyte Growth Factor/Scatter Factor Mitogenic Activity J. Biol. Chem., December 14, 2001; 276(51): 48341 - 48349. [Abstract] [Full Text] [PDF]
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 A. Karihaloo, S. A. Karumanchi, J. Barasch, V. Jha, C. H. Nickel, J. Yang, S. Grisaru, K. T. Bush, S. Nigam, N. D. Rosenblum, et al. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud PNAS, October 12, 2001; (2001) 221205198. [Abstract] [Full Text] [PDF]
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 C. Seidel, M. Borset, O. Hjertner, D. Cao, N. Abildgaard, H. Hjorth-Hansen, R. D. Sanderson, A. Waage, and A. Sundan High levels of soluble syndecan-1 in myeloma-derived bone marrow: modulation of hepatocyte growth factor activity Blood, November 1, 2000; 96(9): 3139 - 3146. [Abstract] [Full Text] [PDF]
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S. Salek-Ardakani, J. R. Arrand, D. Shaw, and M. Mackett Heparin and heparan sulfate bind interleukin-10 and modulate its activity Blood, September 1, 2000; 96(5): 1879 - 1888. [Abstract] [Full Text] [PDF]
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N. Sergeant, M. Lyon, P. S. Rudland, D. G. Fernig, and M. Delehedde Stimulation of DNA Synthesis and Cell Proliferation of Human Mammary Myoepithelial-like Cells by Hepatocyte Growth Factor/Scatter Factor Depends on Heparan Sulfate Proteoglycans and Sustained Phosphorylation of Mitogen-activated Protein Kinases p42/44 J. Biol. Chem., May 26, 2000; 275(22): 17094 - 17099. [Abstract] [Full Text] [PDF]
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C. Riquelme, J. Larrain, E. Schonherr, J. P. Henriquez, H. Kresse, and E. Brandan Antisense Inhibition of Decorin Expression in Myoblasts Decreases Cell Responsiveness to Transforming Growth Factor beta and Accelerates Skeletal Muscle Differentiation J. Biol. Chem., January 26, 2001; 276(5): 3589 - 3596. [Abstract] [Full Text] [PDF]
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M. Delehedde, M. Seve, N. Sergeant, I. Wartelle, M. Lyon, P. S. Rudland, and D. G. Fernig Fibroblast Growth Factor-2 Stimulation of p42/44MAPK Phosphorylation and Ikappa B Degradation Is Regulated by Heparan Sulfate/Heparin in Rat Mammary Fibroblasts J. Biol. Chem., October 20, 2000; 275(43): 33905 - 33910. [Abstract] [Full Text] [PDF]
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M. Lyon, J. A. Deakin, and J. T. Gallagher The Mode of Action of Heparan and Dermatan Sulfates in the Regulation of Hepatocyte Growth Factor/Scatter Factor J. Biol. Chem., January 4, 2002; 277(2): 1040 - 1046. [Abstract] [Full Text] [PDF]
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A. Karihaloo, S. A. Karumanchi, J. Barasch, V. Jha, C. H. Nickel, J. Yang, S. Grisaru, K. T. Bush, S. Nigam, N. D. Rosenblum, et al. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud PNAS, October 23, 2001; 98(22): 12509 - 12514. [Abstract] [Full Text] [PDF]
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