|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 112, Issue 12 2049-2057, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
P Gillis, U Savla, OV Volpert, B Jimenez, CM Waters, RJ Panos and NP Bouck
Department of Microbiology-Immunology, R. H. Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA.
Keratinocyte growth factor (KGF), also called fibroblast growth factor-7, is widely known as a paracrine growth and differentiation factor that is produced by mesenchymal cells and has been thought to act specifically on epithelial cells. Here it is shown to affect a new cell type, the microvascular endothelial cell. At subnanomolar concentrations KGF induced in vivo neovascularization in the rat cornea. In vitro it was not effective against endothelial cells cultured from large vessels, but did act directly on those cultured from small vessels, inducing chemotaxis with an ED50 of 0.02-0.05 ng/ml, stimulating proliferation and activating mitogen activated protein kinase (MAPK). KGF also helped to maintain the barrier function of monolayers of capillary but not aortic endothelial cells, protecting against hydrogen peroxide and vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) induced increases in permeability with an ED50 of 0.2-0.5 ng/ml. These newfound abilities of KGF to induce angiogenesis and to stabilize endothelial barriers suggest that it functions in microvascular tissue as it does in epithelial tissues to protect them against mild insults and to speed their repair after major damage.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Emani, B. Ramlawi, N. R. Sodha, J. Li, C. Bianchi, and F. W. Sellke Increased vascular permeability after cardiopulmonary bypass in patients with diabetes is associated with increased expression of vascular endothelial growth factor and hepatocyte growth factor J. Thorac. Cardiovasc. Surg., July 1, 2009; 138(1): 185 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Koria and S. T. Andreadis KGF promotes integrin {alpha}5 expression through CCAAT/enhancer-binding protein-beta Am J Physiol Cell Physiol, September 1, 2007; 293(3): C1020 - C1031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tillie-Leblond, P. Gosset, R. Le Berre, A. Janin, T. Prangere, A. B. Tonnel, and B. P. H. Guery Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats Eur. Respir. J., July 1, 2007; 30(1): 31 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Cho, T. Ishiwata, E. Uchida, N. Nakazawa, M. Korc, Z. Naito, and T. Tajiri Enhanced Expression of Keratinocyte Growth Factor and Its Receptor Correlates with Venous Invasion in Pancreatic Cancer Am. J. Pathol., June 1, 2007; 170(6): 1964 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Moy, K. Blackwell, M. H. Wu, and H. J. Granger Growth factor- and heparin-dependent regulation of constitutive and agonist-mediated human endothelial barrier function Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2126 - H2135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Geer, D. D. Swartz, and S. T. Andreadis Biomimetic Delivery of Keratinocyte Growth Factor upon Cellular Demand for Accelerated Wound Healing in Vitro and in Vivo Am. J. Pathol., December 1, 2005; 167(6): 1575 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Geiger, C. M. Waters, D. W. Kamp, and M. R. Glucksberg KGF Prevents Oxygen-Mediated Damage in ARPE-19 Cells Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3435 - 3442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Filleur, K. Volz, T. Nelius, Y. Mirochnik, H. Huang, T. A. Zaichuk, M. S. Aymerich, S. P. Becerra, R. Yap, D. Veliceasa, et al. Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer Cancer Res., June 15, 2005; 65(12): 5144 - 5152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Plantier, S. Marchand-Adam, J. Marchal-Somme, G. Leseche, M. Fournier, M. Dehoux, M. Aubier, and B. Crestani Defect of hepatocyte growth factor production by fibroblasts in human pulmonary emphysema Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L641 - L647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Haddad, C. Milla, S. Yang, A. Panoskaltsis-Mortari, S. Hawgood, D. L. Lacey, and B. R. Blazar Surfactant protein A is a required mediator of keratinocyte growth factor after experimental marrow transplantation Am J Physiol Lung Cell Mol Physiol, September 1, 2003; 285(3): L602 - L610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sartori and M.A. Matthay Alveolar epithelial fluid transport in acute lung injury: new insights Eur. Respir. J., November 1, 2002; 20(5): 1299 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ruehl, R. Somasundaram, I. Schoenfelder, R. W. Farndale, C. G. Knight, M. Schmid, R. Ackermann, E. O. Riecken, M. Zeitz, and D. Schuppan The Epithelial Mitogen Keratinocyte Growth Factor Binds to Collagens via the Consensus Sequence Glycine-Proline-Hydroxyproline J. Biol. Chem., July 19, 2002; 277(30): 26872 - 26878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Ware and M. A. Matthay Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L924 - L940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Welsh, B. P. H. Guery, B. P. Deboisblanc, E. P. Dobard, C. Creusy, D. Mercante, S. Nelson, W. R. Summer, and C. M. Mason Keratinocyte growth factor attenuates hydrostatic pulmonary edema in an isolated, perfused rat lung model Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1311 - H1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Panoskaltsis-Mortari, P. A. Taylor, J. S. Rubin, A. Uren, L. A. Welniak, W. J. Murphy, C. L. Farrell, D. L. Lacey, and B. R. Blazar Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury Blood, December 15, 2000; 96(13): 4350 - 4356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B. Viget, B. P. H. Guery, F. Ader, R. Neviere, S. Alfandari, C. Creuzy, M. Roussel-Delvallez, C. Foucher, C. M. Mason, G. Beaucaire, et al. Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1199 - L1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Morikawa, T. A. Walker, L. D. Nielsen, T. Pan, J. L. Cook, and R. J. Mason Effect of Adenovector-Mediated Gene Transfer of Keratinocyte Growth Factor on the Proliferation of Alveolar Type II Cells In Vitro and In Vivo Am. J. Respir. Cell Mol. Biol., November 1, 2000; 23(5): 626 - 635. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. A. WELSH, W. R. SUMMER, E. P. DOBARD, S. NELSON, and C. M. MASON Keratinocyte Growth Factor Prevents Ventilator-induced Lung Injury in an Ex Vivo Rat Model Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1081 - 1086. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. B. Ware and M. A. Matthay The Acute Respiratory Distress Syndrome N. Engl. J. Med., May 4, 2000; 342(18): 1334 - 1349. [Full Text] [PDF]
|
|
