|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 112, Issue 14 2409-2417, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
W Liu, AA Akhand, M Kato, I Yokoyama, T Miyata, K Kurokawa, K Uchida and I Nakashima
Department of Immunology, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan.
Lipid peroxidation has been implicated in the pathogenesis of various diseases. As a major product of membrane lipid peroxidation, 4-hydroxynonenal (HNE) appears after various kinds of oxidative stress, and is known to induce cell growth inhibition. We here analysed the HNE-mediated signal transduction cascade for the growth inhibition of human epidermoid carcinoma A431 cells. HNE dose-dependently induced phosphorylation of multiple cellular proteins including epidermal growth factor receptor (EGFR) in A431 cells, and rapidly upregulated the catalytic actions of EGFR for autophosphorylation and for phosphorylation of casein as an exogenous substrate. Immunoblot analysis by use of HNE-specific antibody demonstrated the binding of HNE to EGFR along with its activation. This binding, which did not induce cross-linking of EGFR, caused a capping of the receptor on the cell surface which mimicked the capping induced by EGF. Phosphorylation and activation of EGFR were followed by phosphorylation of adaptor protein Shc and activation of MAP kinase. Both genistein as a wide spectrum protein tyrosine kinase inhibitor and AG1478 as a specific EGFR tyrosine phosphorylation blocker inhibited activation of EGFR and MAP kinase by HNE. The same inhibitors prevented HNE-mediated growth inhibition, suggesting a close linkage between EGFR/MAP kinase activation and growth inhibition after exposure to HNE. Our results suggest that EGFR may be one of the primary targets of HNE for an oxidative stress-linked cell growth inhibition.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  W. MacNee and R. M. Tuder New Paradigms in the Pathogenesis of Chronic Obstructive Pulmonary Disease I Proceedings of the ATS, September 15, 2009; 6(6): 527 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Grimsrud, H. Xie, T. J. Griffin, and D. A. Bernlohr Oxidative Stress and Covalent Modification of Protein with Bioactive Aldehydes J. Biol. Chem., August 8, 2008; 283(32): 21837 - 21841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Brackenbury, T. H. Davis, C. Chen, E. A. Slat, M. J. Detrow, T. L. Dickendesher, B. Ranscht, and L. L. Isom Voltage-Gated Na+ Channel {beta}1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo J. Neurosci., March 19, 2008; 28(12): 3246 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-I. Jang, E.-J. Lee, P. S. Hart, M. Ramaswami, D. Pallos, and T. C. Hart Germ Line Gain of Function with SOS1 Mutation in Hereditary Gingival Fibromatosis J. Biol. Chem., July 13, 2007; 282(28): 20245 - 20255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Santos-Silva, R. Fairless, M. C. Frame, P. Montague, G. M. Smith, A. Toft, J. S. Riddell, and S. C. Barnett FGF/Heparin Differentially Regulates Schwann Cell and Olfactory Ensheathing Cell Interactions with Astrocytes: A Role in Astrocytosis J. Neurosci., July 4, 2007; 27(27): 7154 - 7167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nakamura, M. Shibuya, H. Nakashima, R. Hisamura, N. Masuda, T. Imagawa, M. Uehara, and K. Tsubota Involvement of Oxidative Stress on Corneal Epithelial Alterations in a Blink-Suppressed Dry Eye Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1552 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Grimsrud, M. J. Picklo Sr., T. J. Griffin, and D. A. Bernlohr Carbonylation of Adipose Proteins in Obesity and Insulin Resistance: Identification of Adipocyte Fatty Acid-binding Protein as a Cellular Target of 4-Hydroxynonenal Mol. Cell. Proteomics, April 1, 2007; 6(4): 624 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Moumtzi, M. Trenker, K. Flicker, E. Zenzmaier, R. Saf, and A. Hermetter Import and fate of fluorescent analogs of oxidized phospholipids in vascular smooth muscle cells J. Lipid Res., March 1, 2007; 48(3): 565 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Sampey, D. L. Carbone, J. A. Doorn, D. A. Drechsel, and D. R. Petersen 4-Hydroxy-2-nonenal Adduction of Extracellular Signal-Regulated Kinase (Erk) and the Inhibition of Hepatocyte Erk-Est-Like Protein-1-Activating Protein-1 Signal Transduction Mol. Pharmacol., March 1, 2007; 71(3): 871 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Sampey, B. J. Stewart, and D. R. Petersen Ethanol-induced Modulation of Hepatocellular Extracellular Signal-regulated Kinase-1/2 Activity via 4-Hydroxynonenal J. Biol. Chem., January 19, 2007; 282(3): 1925 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Liu, H. Chen, T. G. Johns, and A. H. Neufeld Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury. J. Neurosci., July 12, 2006; 26(28): 7532 - 7540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Rahman and I. M. Adcock Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J., July 1, 2006; 28(1): 219 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Missan, P. Linsdell, and T. F. McDonald Tyrosine kinase and phosphatase regulation of slow delayed-rectifier K+ current in guinea-pig ventricular myocytes J. Physiol., June 1, 2006; 573(2): 469 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Xia, S. R. Kumar, R. Masood, S. Zhu, R. Reddy, V. Krasnoperov, D. I. Quinn, S. M. Henshall, R. L. Sutherland, J. K. Pinski, et al. EphB4 Expression and Biological Significance in Prostate Cancer Cancer Res., June 1, 2005; 65(11): 4623 - 4632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Braff, M. A. Hawkins, A. D. Nardo, B. Lopez-Garcia, M. D. Howell, C. Wong, K. Lin, J. E. Streib, R. Dorschner, D. Y. M. Leung, et al. Structure-Function Relationships among Human Cathelicidin Peptides: Dissociation of Antimicrobial Properties from Host Immunostimulatory Activities J. Immunol., April 1, 2005; 174(7): 4271 - 4278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liu, R. Duden, R. D. Phair, and J. Lippincott-Schwartz ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells J. Cell Biol., March 28, 2005; 168(7): 1053 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kumagai, N. Matsukawa, Y. Kaneko, Y. Kusumi, M. Mitsumata, and K. Uchida A Lipid Peroxidation-derived Inflammatory Mediator: IDENTIFICATION OF 4-HYDROXY-2-NONENAL AS A POTENTIAL INDUCER OF CYCLOOXYGENASE-2 IN MACROPHAGES J. Biol. Chem., November 12, 2004; 279(46): 48389 - 48396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Brame, O. Boutaud, S. S. Davies, T. Yang, J. A. Oates, D. Roden, and L. J. Roberts II Modification of Proteins by Isoketal-containing Oxidized Phospholipids J. Biol. Chem., April 2, 2004; 279(14): 13447 - 13451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Kruger and K. B. Reddy Distinct Mechanisms Mediate the Initial and Sustained Phases of Cell Migration in Epidermal Growth Factor Receptor-Overexpressing Cells Mol. Cancer Res., September 1, 2003; 1(11): 801 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Loidl, E. Sevcsik, G. Riesenhuber, H.-P. Deigner, and A. Hermetter Oxidized Phospholipids in Minimally Modified Low Density Lipoprotein Induce Apoptotic Signaling via Activation of Acid Sphingomyelinase in Arterial Smooth Muscle Cells J. Biol. Chem., August 29, 2003; 278(35): 32921 - 32928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Eaton, M. E. Jones, E. McGregor, M. J. Dunn, N. Leeds, H. L. Byers, K.-Y. Leung, M. A. Ward, J. R. Pratt, and M. J. Shattock Reversible Cysteine-Targeted Oxidation of Proteins during Renal Oxidative Stress J. Am. Soc. Nephrol., August 1, 2003; 14(90003): S290 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lu, S. L. Chan, W. Fu, and M. P. Mattson The Lipid Peroxidation Product 4-Hydroxynonenal Facilitates Opening of Voltage-dependent Ca2+ Channels in Neurons by Increasing Protein Tyrosine Phosphorylation J. Biol. Chem., June 28, 2002; 277(27): 24368 - 24375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Eaton, W. Fuller, and M. J. Shattock S-Thiolation of HSP27 Regulates Its Multimeric Aggregate Size Independently of Phosphorylation J. Biol. Chem., June 7, 2002; 277(24): 21189 - 21196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Eaton, H. L. Byers, N. Leeds, M. A. Ward, and M. J. Shattock Detection, Quantitation, Purification, and Identification of Cardiac Proteins S-Thiolated during Ischemia and Reperfusion J. Biol. Chem., March 15, 2002; 277(12): 9806 - 9811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Eaton, D. J Hearse, and M. J Shattock Lipid hydroperoxide modification of proteins during myocardial ischaemia Cardiovasc Res, August 1, 2001; 51(2): 294 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. MIYATA, K. KUROKAWA, and C. VAN YPERSELE DE STRIHOU Advanced Glycation and Lipoxidation End Products: Role of Reactive Carbonyl Compounds Generated during Carbohydrate and Lipid Metabolism J. Am. Soc. Nephrol., September 1, 2000; 11(9): 1744 - 1752. [Full Text]
|
|
|
|
 |
|
 W Liu, M Kato, A. Akhand, A Hayakawa, H Suzuki, T Miyata, K Kurokawa, Y Hotta, N Ishikawa, and I Nakashima 4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death J. Cell Sci., January 2, 2000; 113(4): 635 - 641. [Abstract] [PDF]
|
|
