|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 112, Issue 17 2867-2874, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
H Meinhardt
Max-Planck-Institut fur Entwicklungsbiologie, Spemannstr. 35, D-72076 Tubingen, Germany. hans.meinhardt@tuebingen.mpg.de
A model is proposed for an amplification step in chemotactically sensitive cells or growth cones that accounts for their extraordinary directional sensitivity. It is assumed that cells have an intrinsic pattern forming system that generates the signals for extension of filopods and lamellipods. An external signal such as a graded cue is assumed to impose some directional preference onto the pattern formed. According to the model, a saturating, self-enhancing reaction is coupled with two antagonistic reactions. One antagonist equilibrates rapidly over the whole cell, causing competition between different surface elements of the cell cortex for activation. It will be won by those cortical regions of the cell that are exposed to the highest concentrations of the external graded cues. The second antagonistic reaction is assumed to act more locally and has a longer time constant. It causes a destabilization of peaks after they have formed. While the total activated area on the cell surface is maintained, the disappearance of some hot spots allows the formation of new ones, preferentially at positions specified by the actual external guiding signal. Computer simulations show that the model accounts for the highly dynamic behaviour of chemotactic cells and growth cones. In the absence of external signals, maxima of the internal signals emerge at random positions and disappear after some time. Travelling waves or oscillations in counter phase can emerge on the cell cortex, in agreement with observations reported in the literature. In other ranges of parameters, the model accounts for the generation of a stable cell polarity.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  F. Wang The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis Cold Spring Harb Perspect Biol, October 1, 2009; 1(4): a002980 - a002980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Akiyama, T. Matsu-ura, K. Mikoshiba, and H. Kamiguchi Control of Neuronal Growth Cone Navigation by Asymmetric Inositol 1,4,5-Trisphosphate Signals Sci. Signal., July 14, 2009; 2(79): ra34 - ra34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-J. Rappel and H. Levine Receptor noise limitations on chemotactic sensing PNAS, December 9, 2008; 105(49): 19270 - 19275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Endres and N. S. Wingreen Accuracy of direct gradient sensing by single cells PNAS, October 14, 2008; 105(41): 15749 - 15754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Xu, M. Meier-Schellersheim, J. Yan, and T. Jin Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing J. Cell Biol., October 3, 2007; 178(1): 141 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bouzigues, M. Morel, A. Triller, and M. Dahan Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analyzed by single quantum dot imaging PNAS, July 3, 2007; 104(27): 11251 - 11256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aoki, T. Nakamura, T. Inoue, T. Meyer, and M. Matsuda An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells J. Cell Biol., June 21, 2007; 177(5): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-O. Park and E. Bi Central Roles of Small GTPases in the Development of Cell Polarity in Yeast and Beyond Microbiol. Mol. Biol. Rev., March 1, 2007; 71(1): 48 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Samadani, J. Mettetal, and A. van Oudenaarden Cellular asymmetry and individuality in directional sensing PNAS, August 1, 2006; 103(31): 11549 - 11554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Van Keymeulen, K. Wong, Z. A. Knight, C. Govaerts, K. M. Hahn, K. M. Shokat, and H. R. Bourne To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front J. Cell Biol., July 31, 2006; 174(3): 437 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Levine, D. A. Kessler, and W.-J. Rappel Directional sensing in eukaryotic chemotaxis: A balanced inactivation model PNAS, June 27, 2006; 103(26): 9761 - 9766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Schneider and J. M. Haugh Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts J. Cell Biol., December 5, 2005; 171(5): 883 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, W. J. Rosoff, J. S. Urbach, and G. J. Goodhill Adaptation is not required to explain the long-term response of axons to molecular gradients Development, October 15, 2005; 132(20): 4545 - 4552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Xu, M. Meier-Schellersheim, X. Jiao, L. E. Nelson, and T. Jin Quantitative Imaging of Single Live Cells Reveals Spatiotemporal Dynamics of Multistep Signaling Events of Chemoattractant Gradient Sensing in Dictyostelium Mol. Biol. Cell, February 1, 2005; 16(2): 676 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Janetopoulos, L. Ma, P. N. Devreotes, and P. A. Iglesias Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton PNAS, June 15, 2004; 101(24): 8951 - 8956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Devreotes and C. Janetopoulos Eukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization J. Biol. Chem., May 30, 2003; 278(23): 20445 - 20448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kemkemer, S. Schrank, W. Vogel, H. Gruler, and D. Kaufmann Increased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro PNAS, October 15, 2002; 99(21): 13783 - 13788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Iglesias and A. Levchenko Modeling the Cell's Guidance System Sci. Signal., September 3, 2002; 2002(148): re12 - re12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Meinhardt and P. A. J. de Boer Pattern formation in Escherichia coli: A model for the pole-to-pole oscillations of Min proteins and the localization of the division site PNAS, December 4, 2001; 98(25): 14202 - 14207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Jin, N. Zhang, Y. Long, C. A. Parent, and P. N. Devreotes Localization of the G Protein Complex in Living Cells During Chemotaxis Science, February 11, 2000; 287(5455): 1034 - 1036. [Abstract] [Full Text]
|
|
