spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edom-Vovard, F.
Right arrow Articles by Butler-Browne, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edom-Vovard, F.
Right arrow Articles by Butler-Browne, G. S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 112, Issue 2 191-199, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

The four populations of myoblasts involved in human limb muscle formation are present from the onset of primary myotube formation

F Edom-Vovard, V Mouly, JP Barbet and GS Butler-Browne
Institut d'Embryologie Cellulaire et Moleculaire, CNRS UPR 9064, College de France, 94736 Nogent-Sur-Marne, Cedex, France. buHerb@ext.jussieu.fr.

To understand how and when myogenic precursor cells become committed to their particular developmental programs, we have analysed the different populations of myoblasts which grow out from explants of muscle tissue isolated from human limb buds from the beginning of primary fibre formation throughout subsequent development and post-natal growth. Four phenotypically distinct types of myoblasts were identified on the basis of their expression of desmin, myogenin and myosin heavy chain isoforms (MyHC), and after 5 and 20 divisions, cells were cloned. All four types of myoblasts were present at the beginning of primary myogenesis. Each respective phenotype was stably heritable through cloning and subsequent proliferation. The type 1 clones correspond to a novel class of myoblasts never described during human development, that biochemically differentiates, but does not fuse. Type 2 clones are composed of small myotubes expressing only embryonic MyHC. Type 3 clones are composed of thin and long myotubes expressing both embryonic and fetal MyHCs. The type 4 clones are composed of myotubes that have a phenotype very similar to human satellite cells. Contrasting with others species, no other population of myoblasts appear during fetal development and only the relative number of these four types changes.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Stem CellsHome page
D. C. Andersen, S. J. Petersson, L. H. Jorgensen, P. Bollen, P. B. Jensen, B. Teisner, H. D. Schroeder, and C. H. Jensen
Characterization of DLK1+ Cells Emerging During Skeletal Muscle Remodeling in Response to Myositis, Myopathies, and Acute Injury
Stem Cells, April 1, 2009; 27(4): 898 - 908.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Guigal, M. Rodriguez, R. N. Cooper, S. Dromaint, J. P. Di Santo, V. Mouly, J. A. Boutin, and J.-P. Galizzi
Uncoupling Protein-3 (UCP3) mRNA Expression in Reconstituted Human Muscle after Myoblast Transplantation in RAG2-/-/gamma c/C5- Immunodeficient Mice
J. Biol. Chem., November 27, 2002; 277(49): 47407 - 47411.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. D. Grounds, J. D. White, N. Rosenthal, and M. A. Bogoyevitch
The Role of Stem Cells in Skeletal and Cardiac Muscle Repair
J. Histochem. Cytochem., May 1, 2002; 50(5): 589 - 610.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
D. Furling, L. Coiffier, V. Mouly, J.P. Barbet, J. Lacau St Guily, K. Taneja, G. Gourdon, C. Junien, and G.S. Butler-Browne
Defective satellite cells in congenital myotonic dystrophy
Hum. Mol. Genet., September 1, 2001; 10(19): 2079 - 2087.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 1999