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Journal of Cell Science, Vol 112, Issue 21 3603-3617, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
J Schlondorff and CP Blobel
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Box 368, Tri-Institutional (Cornell/ Rockefeller University/Sloan-Kettering Institute) MD/PhD Program, New York, NY 10021, USA.
Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the ectodomains of proteins such as tumor necrosis factor (&agr;) (TNF(&agr;)), and because of their roles in Notch-mediated signaling, neurogenesis and muscle fusion. ADAMs are integral membrane glycoproteins that contain a disintegrin domain, which is related to snake-venom integrin ligands, and a metalloprotease domain (which can contain or lack a catalytic site). Here, we review and critically discuss current topics in the ADAMs field, including the central role of fertilin in fertilization, the role of the TNF(&agr;) convertase in protein ectodomain processing, the role of Kuzbanian in Notch signaling, and links between ADAMs and processing of the amyloid-precursor protein.
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V. Budagian, E. Bulanova, Z. Orinska, A. Ludwig, S. Rose-John, P. Saftig, E. C. Borden, and S. Bulfone-Paus Natural Soluble Interleukin-15R{alpha} Is Generated by Cleavage That Involves the Tumor Necrosis Factor-{alpha}-converting Enzyme (TACE/ADAM17) J. Biol. Chem., September 24, 2004; 279(39): 40368 - 40375. [Abstract] [Full Text] [PDF]
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A. R. Walmsley, G. McCombie, U. Neumann, D. Marcellin, R. Hillenbrand, A. K. Mir, and S. Frentzel Zinc metalloproteinase-mediated cleavage of the human Nogo-66 receptor J. Cell Sci., September 1, 2004; 117(19): 4591 - 4602. [Abstract] [Full Text] [PDF]
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H. Nishimura, E. Kim, T. Nakanishi, and T. Baba Possible Function of the ADAM1a/ADAM2 Fertilin Complex in the Appearance of ADAM3 on the Sperm Surface J. Biol. Chem., August 13, 2004; 279(33): 34957 - 34962. [Abstract] [Full Text] [PDF]
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J. Zhang, H. Li, J. Wang, Z. Dong, S. Mian, and F.-S. X. Yu Role of EGFR Transactivation in Preventing Apoptosis in Pseudomonas aeruginosa-Infected Human Corneal Epithelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2569 - 2576. [Abstract] [Full Text] [PDF]
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P. E. Gonzales, A. Solomon, A. B. Miller, M. A. Leesnitzer, I. Sagi, and M. E. Milla Inhibition of the Tumor Necrosis Factor-{alpha}-converting Enzyme by Its Pro Domain J. Biol. Chem., July 23, 2004; 279(30): 31638 - 31645. [Abstract] [Full Text] [PDF]
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H. Ohnishi, H. Kobayashi, H. Okazawa, Y. Ohe, K. Tomizawa, R. Sato, and T. Matozaki Ectodomain Shedding of SHPS-1 and Its Role in Regulation of Cell Migration J. Biol. Chem., July 2, 2004; 279(27): 27878 - 27887. [Abstract] [Full Text] [PDF]
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M. M. Kessels and B. Qualmann The syndapin protein family: linking membrane trafficking with the cytoskeleton J. Cell Sci., July 1, 2004; 117(15): 3077 - 3086. [Abstract] [Full Text] [PDF]
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 N. L. Tsakadze, U. Sen, Z. Zhao, S. D. Sithu, W. R. English, and S. E. D'Souza Signals mediating cleavage of intercellular adhesion molecule-1 Am J Physiol Cell Physiol, July 1, 2004; 287(1): C55 - C63. [Abstract] [Full Text] [PDF]
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O. Nagano, D. Murakami, D. Hartmann, B. de Strooper, P. Saftig, T. Iwatsubo, M. Nakajima, M. Shinohara, and H. Saya Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation J. Cell Biol., June 21, 2004; 165(6): 893 - 902. [Abstract] [Full Text] [PDF]
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D. V. Bax, A. J. Messent, J. Tart, M. van Hoang, J. Kott, R. A. Maciewicz, and M. J. Humphries Integrin {alpha}5{beta}1 and ADAM-17 Interact in Vitro and Co-localize in Migrating HeLa Cells J. Biol. Chem., May 21, 2004; 279(21): 22377 - 22386. [Abstract] [Full Text] [PDF]
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S. Abel, C. Hundhausen, R. Mentlein, A. Schulte, T. A. Berkhout, N. Broadway, D. Hartmann, R. Sedlacek, S. Dietrich, B. Muetze, et al. The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN-{gamma} and TNF-{alpha} and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10 J. Immunol., May 15, 2004; 172(10): 6362 - 6372. [Abstract] [Full Text] [PDF]
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M. J. Ludeman, Y. W. Zheng, K. Ishii, and S. R. Coughlin Regulated Shedding of PAR1 N-terminal Exodomain from Endothelial Cells J. Biol. Chem., April 30, 2004; 279(18): 18592 - 18599. [Abstract] [Full Text] [PDF]
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