|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 112, Issue 21 3747-3756, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
A Karaiskou, C Jessus, T Brassac and R Ozon
Laboratoire de Physiologie de la Reproduction, ESA 7080-CNRS, INRA, Universite Pierre et Marie Curie, Boite 13, 75252 Paris cedex 05, France.
The auto-catalytic activation of the cyclin-dependent kinase Cdc2 or MPF (M-phase promoting factor) is an irreversible process responsible for the entry into M phase. In Xenopus oocyte, a positive feed-back loop between Cdc2 kinase and its activating phosphatase Cdc25 allows the abrupt activation of MPF and the entry into the first meiotic division. We have studied the Cdc2/Cdc25 feed-back loop using cell-free systems derived from Xenopus prophase-arrested oocyte. Our findings support the following two-step model for MPF amplification: during the first step, Cdc25 acquires a basal catalytic activity resulting in a linear activation of Cdc2 kinase. In turn Cdc2 partially phosphorylates Cdc25 but no amplification takes place; under this condition Plx1 kinase and its activating kinase, Plkk1 are activated. However, their activity is not required for the partial phosphorylation of Cdc25. This first step occurs independently of PP2A or Suc1/Cks-dependent Cdc25/Cdc2 association. On the contrary, the second step involves the full phosphorylation and activation of Cdc25 and the initiation of the amplification loop. It depends both on PP2A inhibition and Plx1 kinase activity. Suc1-dependent Cdc25/Cdc2 interaction is required for this process.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Zhao, O. Haccard, R. Wang, J. Yu, J. Kuang, C. Jessus, and M. L. Goldberg Roles of Greatwall Kinase in the Regulation of Cdc25 Phosphatase Mol. Biol. Cell, April 1, 2008; 19(4): 1317 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-G. Liang, Y.-Q. Su, H.-Y. Fan, H. Schatten, and Q.-Y. Sun Mechanisms Regulating Oocyte Meiotic Resumption: Roles of Mitogen-Activated Protein Kinase Mol. Endocrinol., September 1, 2007; 21(9): 2037 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Tallada, A. J. Bridge, P. A. Emery, and I. M. Hagan Suppression of the Schizosaccharomyces pombe cut12.1 Cell-Cycle Defect by Mutations in cdc25 and Genes Involved in Transcriptional and Translational Control Genetics, May 1, 2007; 176(1): 73 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Horn, J. Thelu, A. Garcia, C. Albiges-Rizo, M. R. Block, and J. Viallet Functional Interaction of Aurora-A and PP2A during Mitosis Mol. Biol. Cell, April 1, 2007; 18(4): 1233 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Maton, T. Lorca, J.-A. Girault, R. Ozon, and C. Jessus Differential regulation of Cdc2 and Aurora-A in Xenopus oocytes: a crucial role of phosphatase 2A J. Cell Sci., June 1, 2005; 118(11): 2485 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Karaiskou, A.-C. Lepretre, G. Pahlavan, D. Du Pasquier, R. Ozon, and C. Jessus Polo-like kinase confers MPF autoamplification competence to growing Xenopus oocytes Development, April 1, 2004; 131(7): 1543 - 1552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. MacIver, K. Tanaka, A. M. Robertson, and I. M. Hagan Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe Genes & Dev., June 15, 2003; 17(12): 1507 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Maton, C. Thibier, A. Castro, T. Lorca, C. Prigent, and C. Jessus Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes J. Biol. Chem., June 6, 2003; 278(24): 21439 - 21449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Reynolds and H. Ohkura Polo boxes form a single functional domain that mediates interactions with multiple proteins in fission yeast polo kinase J. Cell Sci., April 1, 2003; 116(7): 1377 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B.-Y. Josefsberg, D. Galiani, S. Lazar, O. Kaufman, R. Seger, and N. Dekel Maturation-Promoting Factor Governs Mitogen-Activated Protein Kinase Activation and Interphase Suppression During Meiosis of Rat Oocytes Biol Reprod, April 1, 2003; 68(4): 1282 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Qu, J. N. Weiss, and W. R. MacLellan Regulation of the mammalian cell cycle: a model of the G1-to-S transition Am J Physiol Cell Physiol, February 1, 2003; 284(2): C349 - C364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Okubo, J. M. Lehman, and T. D. Friedrich Negative Regulation of Mitotic Promoting Factor by the Checkpoint Kinase Chk1 in Simian Virus 40 Lytic Infection J. Virol., December 20, 2002; 77(2): 1257 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. De Smedt, R. Poulhe, X. Cayla, F. Dessauge, A. Karaiskou, C. Jessus, and R. Ozon Thr-161 Phosphorylation of Monomeric Cdc2. REGULATION BY PROTEIN PHOSPHATASE 2C IN XENOPUS OOCYTES J. Biol. Chem., August 2, 2002; 277(32): 28592 - 28600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Schmitt and A. R. Nebreda Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A PNAS, April 2, 2002; 99(7): 4361 - 4366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P. Budde, A. Kumagai, W. G. Dunphy, and R. Heald Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts J. Cell Biol., April 2, 2001; 153(1): 149 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Perez-Mongiovi, C. Beckhelling, P. Chang, C. C. Ford, and E. Houliston Nuclei and Microtubule Asters Stimulate Maturation/M Phase Promoting Factor (Mpf) Activation in Xenopus Eggs and Egg Cytoplasmic Extracts J. Cell Biol., September 4, 2000; 150(5): 963 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Frank-Vaillant, O Haccard, C Thibier, R Ozon, Y Arlot-Bonnemains, C Prigent, and C Jessus Progesterone regulates the accumulation and the activation of Eg2 kinase in Xenopus oocytes J. Cell Sci., January 4, 2000; 113(7): 1127 - 1138. [Abstract] [PDF]
|
|
|
|
|
|
R. Wintjens, J.-M. Wieruszeski, H. Drobecq, P. Rousselot-Pailley, L. Buee, G. Lippens, and I. Landrieu 1H NMR Study on the Binding of Pin1 Trp-Trp Domain with Phosphothreonine Peptides J. Biol. Chem., June 29, 2001; 276(27): 25150 - 25156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nakahata, Y. Katsu, K. Mita, K. Inoue, Y. Nagahama, and M. Yamashita Biochemical Identification of Xenopus Pumilio as a Sequence-specific Cyclin B1 mRNA-binding Protein That Physically Interacts with a Nanos Homolog, Xcat-2, and a Cytoplasmic Polyadenylation Element-binding Protein J. Biol. Chem., June 8, 2001; 276(24): 20945 - 20953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Karaiskou, L. H. Perez, I. Ferby, R. Ozon, C. Jessus, and A. R. Nebreda Differential Regulation of Cdc2 and Cdk2 by RINGO and Cyclins J. Biol. Chem., September 14, 2001; 276(38): 36028 - 36034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schmitt and A. R. Nebreda Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A PNAS, April 2, 2002; 99(7): 4361 - 4366. [Abstract] [Full Text] [PDF]
|
|
