Journal of Cell Science, Vol 112, Issue 23 4305-4313, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

Differential expression of allograft inflammatory factor 1 and of glutathione peroxidase during auto- and allograft response in marine sponges

M Kruse, R Steffen, R Batel, IM Muller and WE Muller
Institut fur Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universitat, Duesbergweg 6, D-55099 Mainz, Germany.

Very recently, Porifera (sponges) have been proven to be suitable model systems to study auto- and allograft recognition at the molecular level. Several potential immune molecules have been isolated from the marine sponges Suberites domuncula and Geodia cydonium, among them those which comprise Ig-like domains in their extracellular part. Here we report on the isolation of two cDNAs from S. domuncula that code for molecules involved in mammals in cytokine-mediated graft response; a putative allograft inflammatory factor 1 (AIF-1) and a non-selenium glutathione peroxidase (GPX). Both polypeptides share high similarity with the corresponding mammalian proteins. The expression of the two genes during auto- and allograft recognition in S. domuncula and G. cydonium was determined. It is shown that the expression of the AIF-1-related gene is upregulated only in allografts, while the GPX-related gene is expressed in the fusion zones formed between auto- as well as allografts. Taken together, these findings suggest that besides cell-mediated defense reactions a cytokine-dependent immune response is also elicited during graft recognition in sponges.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				X. Fernandez-Busquets, A. Kornig, I. Bucior, M. M. Burger, and D. Anselmetti Self-Recognition and Ca2+-Dependent Carbohydrate-Carbohydrate Cell Adhesion Provide Clues to the Cambrian Explosion Mol. Biol. Evol., November 1, 2009; 26(11): 2551 - 2561. [Abstract] [Full Text] [PDF]

				Y. Tian, S. Jain, S. E. Kelemen, and M. V. Autieri AIF-1 expression regulates endothelial cell activation, signal transduction, and vasculogenesis Am J Physiol Cell Physiol, February 1, 2009; 296(2): C256 - C266. [Abstract] [Full Text] [PDF]

				L. J. Sommerville, C. Xing, S. E. Kelemen, S. Eguchi, and M. V. Autieri Inhibition of allograft inflammatory factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity Cardiovasc Res, January 1, 2009; 81(1): 206 - 215. [Abstract] [Full Text] [PDF]

				L. J. Sommerville, S. E. Kelemen, and M. V. Autieri Increased Smooth Muscle Cell Activation and Neointima Formation in Response to Injury in AIF-1 Transgenic Mice Arterioscler Thromb Vasc Biol, January 1, 2008; 28(1): 47 - 53. [Abstract] [Full Text] [PDF]

				C. Sabella, E. Faszewski, L. Himic, K. M. Colpitts, J. Kaltenbach, M. M. Burger, and X. Fernandez-Busquets Cyclosporin A Suspends Transplantation Reactions in the Marine Sponge Microciona prolifera J. Immunol., November 1, 2007; 179(9): 5927 - 5935. [Abstract] [Full Text] [PDF]

				M. Kimura, Y. Kawahito, H. Obayashi, M. Ohta, H. Hara, T. Adachi, D. Tokunaga, T. Hojo, M. Hamaguchi, A. Omoto, et al. A Critical Role for Allograft Inflammatory Factor-1 in the Pathogenesis of Rheumatoid Arthritis J. Immunol., March 1, 2007; 178(5): 3316 - 3322. [Abstract] [Full Text] [PDF]

				Y. Tian and M. V. Autieri Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation Am J Physiol Cell Physiol, February 1, 2007; 292(2): C841 - C849. [Abstract] [Full Text] [PDF]

				H. C. Schroder, A. Boreiko, M. Korzhev, M. N. Tahir, W. Tremel, C. Eckert, H. Ushijima, I. M. Muller, and W. E. G. Muller Co-expression and Functional Interaction of Silicatein with Galectin: MATRIX-GUIDED FORMATION OF SILICEOUS SPICULES IN THE MARINE DEMOSPONGE SUBERITES DOMUNCULA J. Biol. Chem., April 28, 2006; 281(17): 12001 - 12009. [Abstract] [Full Text] [PDF]

				Y. Tian, S. E. Kelemen, and M. V. Autieri Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1083 - C1091. [Abstract] [Full Text] [PDF]

				L. F. Cadavid Self/non-self Discrimination in Basal Metazoa: Genetics of Allorecognition in the Hydroid Hydractinia Integr. Comp. Biol., August 1, 2005; 45(4): 623 - 630. [Abstract] [Full Text] [PDF]

				S. E. Kelemen and M. V. Autieri Expression of Allograft Inflammatory Factor-1 in T Lymphocytes: A Role in T-Lymphocyte Activation and Proliferative Arteriopathies Am. J. Pathol., August 1, 2005; 167(2): 619 - 626. [Abstract] [Full Text] [PDF]

				W. E. G. Muller and I. M. Muller Origin of the Metazoan Immune System: Identification of the Molecules and Their Functions in Sponges Integr. Comp. Biol., April 1, 2003; 43(2): 281 - 292. [Abstract] [Full Text] [PDF]

				M. V. Autieri, S. Kelemen, B. A. Thomas, E. D. Feller, B. I. Goldman, and H. J. Eisen Allograft Inflammatory Factor-1 Expression Correlates With Cardiac Rejection and Development of Cardiac Allograft Vasculopathy Circulation, October 22, 2002; 106(17): 2218 - 2223. [Abstract] [Full Text] [PDF]

				M. V. Autieri and C. M. Carbone Overexpression of Allograft Inflammatory Factor-1 Promotes Proliferation of Vascular Smooth Muscle Cells by Cell Cycle Deregulation Arterioscler Thromb Vasc Biol, September 1, 2001; 21(9): 1421 - 1426. [Abstract] [Full Text] [PDF]

				W. E. G. Muller, R. Steffen, B. Lorenz, R. Batel, M. Kruse, A. Krasko, I. M. Muller, and H. C. Schroder Suppression of allograft rejection in the sponge Suberites domuncula by FK506 and expression of genes encoding FK506-binding proteins in allografts J. Exp. Biol., January 7, 2001; 204(13): 2197 - 2207. [Abstract] [Full Text] [PDF]