spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Radhakrishna, H.
Right arrow Articles by Donaldson, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Radhakrishna, H.
Right arrow Articles by Donaldson, J. G.

Journal of Cell Science, Vol 112, Issue 6 855-866, Copyright © 1999 by Company of Biologists

JOURNAL ARTICLES

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

H Radhakrishna, O Al-Awar, Z Khachikian and JG Donaldson
Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA.

The ARF6 GTPase regulates a novel endosomal-plasma membrane recycling pathway and influences cortical actin remodeling. Here we examined the relationship between ARF6 and Rac1, a Rho family GTPase, implicated in cortical actin rearrangements. Endogenous Rac1 colocalized with ARF6 at the plasma membrane and on the ARF6 recycling endosome in untransfected HeLa and primary human fibroblast cells. In transfected HeLa cells Rac1 and ARF6 also colocalized. Cells expressing wild-type ARF6 or Rac1 formed actin-containing surface protrusions and membrane ruffles, respectively, upon treatment with the G protein activator aluminum fluoride. Aluminum fluoride-treatment of cells transfected with equivalent amounts of plasmid resulted in enhanced membrane ruffling, with protrusions appearing as Rac expression was lowered. Co-expression of the dominant negative, GTP binding-defective ARF6 T27N mutant inhibited the aluminum fluoride-induced ruffling observed in cells expressing Rac1, and the constitutive ruffling observed in cells expressing the activated Rac1 Q61L mutant. In contrast, co-expression of the GTP-binding-defective, T17N mutant of either Rac1 or Cdc42 with ARF6 did not inhibit the aluminum fluoride-induced surface protrusions, nor did inactivation of Rho with C3-transferase. These observations suggest that ARF6, a non-Rho family GTPase, can, by itself, alter cortical actin and can influence the ability of Rac1 to form lamellipodia, in part, by regulating its trafficking to the plasma membrane.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
V. L. Ha, S. Bharti, H. Inoue, W. C. Vass, F. Campa, Z. Nie, A. de Gramont, Y. Ward, and P. A. Randazzo
ASAP3 Is a Focal Adhesion-associated Arf GAP That Functions in Cell Migration and Invasion
J. Biol. Chem., May 30, 2008; 283(22): 14915 - 14926.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
V. Kolsch, P. G. Charest, and R. A. Firtel
The regulation of cell motility and chemotaxis by phospholipid signaling
J. Cell Sci., March 1, 2008; 121(5): 551 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Yano, I. Kobayashi, Y. Onodera, F. Luton, M. Franco, Y. Mazaki, S. Hashimoto, K. Iwai, Z. Ronai, and H. Sabe
Fbx8 Makes Arf6 Refractory to Function via Ubiquitination
Mol. Biol. Cell, March 1, 2008; 19(3): 822 - 832.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. Porat-Shliom, Y. Kloog, and J. G. Donaldson
A Unique Platform for H-Ras Signaling Involving Clathrin-independent Endocytosis
Mol. Biol. Cell, March 1, 2008; 19(3): 765 - 775.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
B. E. Richardson, K. Beckett, S. J. Nowak, and M. K. Baylies
SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion
Development, December 15, 2007; 134(24): 4357 - 4367.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
M. M. Murph, J. Hurst-Kennedy, V. Newton, D. N. Brindley, and H. Radhakrishna
Lysophosphatidic Acid Decreases the Nuclear Localization and Cellular Abundance of the p53 Tumor Suppressor in A549 Lung Carcinoma Cells
Mol. Cancer Res., November 1, 2007; 5(11): 1201 - 1211.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. D. Moore, E. E. Thacker, J. Larimore, D. Gaston, A. Underwood, B. Kearns, S. I. Patterson, T. Jackson, C. Chapleau, L. Pozzo-Miller, et al.
The neuronal Arf GAP centaurin {alpha}1 modulates dendritic differentiation
J. Cell Sci., August 1, 2007; 120(15): 2683 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. A. Cohen, A. Honda, P. Varnai, F. D. Brown, T. Balla, and J. G. Donaldson
Active Arf6 Recruits ARNO/Cytohesin GEFs to the PM by Binding Their PH Domains
Mol. Biol. Cell, June 1, 2007; 18(6): 2244 - 2253.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
X. Chen, T. D. Abair, M. R. Ibanez, Y. Su, M. R. Frey, R. S. Dise, D. B. Polk, A. B. Singh, R. C. Harris, R. Zent, et al.
Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation
Mol. Cell. Biol., May 1, 2007; 27(9): 3313 - 3326.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Cotton, P.-L. Boulay, T. Houndolo, N. Vitale, J. A. Pitcher, and A. Claing
Endogenous ARF6 Interacts with Rac1 upon Angiotensin II Stimulation to Regulate Membrane Ruffling and Cell Migration
Mol. Biol. Cell, February 1, 2007; 18(2): 501 - 511.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H.-Y. Yoon, K. Miura, E. J. Cuthbert, K. K. Davis, B. Ahvazi, J. E. Casanova, and P. A. Randazzo
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP
J. Cell Sci., November 15, 2006; 119(22): 4650 - 4666.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
L. E. Goldfinger, C. Ptak, E. D. Jeffery, J. Shabanowitz, D. F. Hunt, and M. H. Ginsberg
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration
J. Cell Biol., September 11, 2006; 174(6): 877 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, C. Taya, H. Shitara, H. Yonekawa, et al.
Crucial Role of the Small GTPase ARF6 in Hepatic Cord Formation during Liver Development.
Mol. Cell. Biol., August 1, 2006; 26(16): 6149 - 6156.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Hiroi, A. Someya, W. Thompson, J. Moss, and M. Vaughan
GEP100/BRAG2: Activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and {alpha}-catenin
PNAS, July 11, 2006; 103(28): 10672 - 10677.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Shmuel, L. C. Santy, S. Frank, D. Avrahami, J. E. Casanova, and Y. Altschuler
ARNO through Its Coiled-coil Domain Regulates Endocytosis at the Apical Surface of Polarized Epithelial Cells
J. Biol. Chem., May 12, 2006; 281(19): 13300 - 13308.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
P. F. Esteban, H.-Y. Yoon, J. Becker, S. G. Dorsey, P. Caprari, M. E. Palko, V. Coppola, H. U. Saragovi, P. A. Randazzo, and L. Tessarollo
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin
J. Cell Biol., April 24, 2006; 173(2): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. Choi, Z. A. Karim, and S. W. Whiteheart
Arf6 plays an early role in platelet activation by collagen and convulxin
Blood, April 15, 2006; 107(8): 3145 - 3152.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S.-Y. Jiang and S. Ramachandran
Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes
Physiol Genomics, February 23, 2006; 24(3): 235 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Krugmann, S. Andrews, L. Stephens, and P. T. Hawkins
ARAP3 is essential for formation of lamellipodia after growth factor stimulation
J. Cell Sci., February 1, 2006; 119(3): 425 - 432.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y. Aikawa, X. Xia, and T. F.J. Martin
SNAP25, but Not Syntaxin 1A, Recycles via an ARF6-regulated Pathway in Neuroendocrine Cells
Mol. Biol. Cell, February 1, 2006; 17(2): 711 - 722.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. E. Robertson, S. R. G. Setty, A. Sitaram, M. S. Marks, R. E. Lewis, and M. M. Chou
Extracellular Signal-regulated Kinase Regulates Clathrin-independent Endosomal Trafficking
Mol. Biol. Cell, February 1, 2006; 17(2): 645 - 657.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. Hyman, M. Shmuel, and Y. Altschuler
Actin Is Required for Endocytosis at the Apical Surface of Madin-Darby Canine Kidney Cells where ARF6 and Clathrin Regulate the Actin Cytoskeleton
Mol. Biol. Cell, January 1, 2006; 17(1): 427 - 437.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. J. Reddig, D. Xu, and R. L. Juliano
Regulation of p21-activated Kinase-independent Rac1 Signal Transduction by Nischarin
J. Biol. Chem., September 2, 2005; 280(35): 30994 - 31002.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Koizumi, S. Naramoto, S. Sawa, N. Yahara, T. Ueda, A. Nakano, M. Sugiyama, and H. Fukuda
VAN3 ARF-GAP-mediated vesicle transport is involved in leaf vascular network formation
Development, April 1, 2005; 132(7): 1699 - 1711.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Ikeda, M. Ushio-Fukai, L. Zuo, T. Tojo, S. Dikalov, N. A. Patrushev, and R. W. Alexander
Novel Role of ARF6 in Vascular Endothelial Growth Factor-Induced Signaling and Angiogenesis
Circ. Res., March 4, 2005; 96(4): 467 - 475.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y. LI, W. G. KELLY, J. M. LOGSDON JR, A. M. SCHURKO, B. D. HARFE, K. L. HILL-HARFE, and R. A. KAHN
Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans
FASEB J, December 1, 2004; 18(15): 1834 - 1850.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. Martinu, J. M. Masuda-Robens, S. E. Robertson, L. C. Santy, J. E. Casanova, and M. M. Chou
The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6
Mol. Cell. Biol., November 15, 2004; 24(22): 9752 - 9762.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
W. T. Arthur, L. A. Quilliam, and J. A. Cooper
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
J. Cell Biol., October 11, 2004; 167(1): 111 - 122.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
U. Rescher, D. Ruhe, C. Ludwig, N. Zobiack, and V. Gerke
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes
J. Cell Sci., July 15, 2004; 117(16): 3473 - 3480.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Onel, L. Bolke, and C. Klambt
The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit
Development, June 1, 2004; 131(11): 2587 - 2594.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
R. T. Watson, M. Kanzaki, and J. E. Pessin
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Endocr. Rev., April 1, 2004; 25(2): 177 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Dang, Z. Li, E. Y. Skolnik, and H. Fares
Disease-related Myotubularins Function in Endocytic Traffic in Caenorhabditis elegans
Mol. Biol. Cell, January 1, 2004; 15(1): 189 - 196.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
D. J. Hernandez-Deviez, M. G. Roth, J. E. Casanova, and J. M. Wilson
ARNO and ARF6 Regulate Axonal Elongation and Branching through Downstream Activation of Phosphatidylinositol 4-Phosphate 5-Kinase {alpha}
Mol. Biol. Cell, January 1, 2004; 15(1): 111 - 120.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
G. Schlunck, H. Damke, W. B. Kiosses, N. Rusk, M. H. Symons, C. M. Waterman-Storer, S. L. Schmid, and M. A. Schwartz
Modulation of Rac Localization and Function by Dynamin
Mol. Biol. Cell, January 1, 2004; 15(1): 256 - 267.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. Prigent, T. Dubois, G. Raposo, V. Derrien, D. Tenza, C. Rosse, J. Camonis, and P. Chavrier
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector
J. Cell Biol., December 8, 2003; 163(5): 1111 - 1121.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
B. Nichols
Caveosomes and endocytosis of lipid rafts
J. Cell Sci., December 1, 2003; 116(23): 4707 - 4714.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. T. R. Lawrence and M. J. Birnbaum
ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate
PNAS, November 11, 2003; 100(23): 13320 - 13325.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. Zakrzewska, M. Perron, A. Laroche, and D. Pallotta
A Role for GEA1 and GEA2 in the Organization of the Actin Cytoskeleton in Saccharomyces cerevisiae
Genetics, November 1, 2003; 165(3): 985 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. G. Donaldson
Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane
J. Biol. Chem., October 24, 2003; 278(43): 41573 - 41576.
[Full Text] [PDF]

Home page
 J. Cell Biol.Home page
B. Riggs, W. Rothwell, S. Mische, G. R.X. Hickson, J. Matheson, T. S. Hays, G. W. Gould, and W. Sullivan
Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11
J. Cell Biol., October 13, 2003; 163(1): 143 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
H. Sabe
Requirement for Arf6 in Cell Adhesion, Migration, and Cancer Cell Invasion
J. Biochem., October 1, 2003; 134(4): 485 - 489.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Cascone, E. Audero, E. Giraudo, L. Napione, F. Maniero, M. R. Philips, J. G. Collard, G. Serini, and F. Bussolino
Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1
Blood, October 1, 2003; 102(7): 2482 - 2490.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. Ge, A. Gidwani, H. A. Brown, D. Holowka, B. Baird, and J. H. Freed
Ordered and Disordered Phases Coexist in Plasma Membrane Vesicles of RBL-2H3 Mast Cells. An ESR Study
Biophys. J., August 1, 2003; 85(2): 1278 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. Lamorte, S. Rodrigues, V. Sangwan, C. E. Turner, and M. Park
Crk Associates with a Multimolecular Paxillin/GIT2/{beta}-PIX Complex and Promotes Rac-dependent Relocalization of Paxillin to Focal Contacts
Mol. Biol. Cell, July 1, 2003; 14(7): 2818 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. D. Paterson, R. G. Parton, C. Ferguson, J. L. Stow, and A. S. Yap
Characterization of E-cadherin Endocytosis in Isolated MCF-7 and Chinese Hamster Ovary Cells: THE INITIAL FATE OF UNBOUND E-CADHERIN
J. Biol. Chem., May 30, 2003; 278(23): 21050 - 21057.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Palacios and C. D'Souza-Schorey
Modulation of Rac1 and ARF6 Activation during Epithelial Cell Scattering
J. Biol. Chem., May 2, 2003; 278(19): 17395 - 17400.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
C. Albertinazzi, L. Za, S. Paris, and I. de Curtis
ADP-Ribosylation Factor 6 and a Functional PIX/p95-APP1 Complex Are Required for Rac1B-mediated Neurite Outgrowth
Mol. Biol. Cell, April 1, 2003; 14(4): 1295 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. M. Masuda-Robens, S. N. Kutney, H. Qi, and M. M. Chou
The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling
Mol. Cell. Biol., March 15, 2003; 23(6): 2151 - 2161.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Nie, K. T. Stanley, S. Stauffer, K. M. Jacques, D. S. Hirsch, J. Takei, and P. A. Randazzo
AGAP1, an Endosome-associated, Phosphoinositide-dependent ADP-ribosylation Factor GTPase-activating Protein That Affects Actin Cytoskeleton
J. Biol. Chem., December 6, 2002; 277(50): 48965 - 48975.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. K. Sastry, P. D. Lyons, M. D. Schaller, and K. Burridge
PTP-PEST controls motility through regulation of Rac1
J. Cell Sci., November 15, 2002; 115(22): 4305 - 4316.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. C. Santy
Characterization of a Fast Cycling ADP-ribosylation Factor 6 Mutant
J. Biol. Chem., October 18, 2002; 277(43): 40185 - 40188.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
N. Vitale, S. Chasserot-Golaz, Y. Bailly, N. Morinaga, M. A. Frohman, and M.-F. Bader
Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane
J. Cell Biol., October 14, 2002; 159(1): 79 - 89.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Oshiro, S. Koyama, S. Sugiyama, A. Kondo, Y. Onodera, T. Asahara, H. Sabe, and A. Kikuchi
Interaction of POB1, a Downstream Molecule of Small G Protein Ral, with PAG2, a Paxillin-binding Protein, Is Involved in Cell Migration
J. Biol. Chem., October 4, 2002; 277(41): 38618 - 38626.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
N. O'Luanaigh, R. Pardo, A. Fensome, V. Allen-Baume, D. Jones, M. R. Holt, and S. Cockcroft
Continual Production of Phosphatidic Acid by Phospholipase D Is Essential for Antigen-stimulated Membrane Ruffling in Cultured Mast Cells
Mol. Biol. Cell, October 1, 2002; 13(10): 3730 - 3746.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Mansour, S. Y. Lee, and B. Pohajdak
The N-terminal Coiled Coil Domain of the Cytohesin/ARNO Family of Guanine Nucleotide Exchange Factors Interacts with the Scaffolding Protein CASP
J. Biol. Chem., August 23, 2002; 277(35): 32302 - 32309.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. K. Schweitzer and C. D'Souza-Schorey
Localization and Activation of the ARF6 GTPase during Cleavage Furrow Ingression and Cytokinesis
J. Biol. Chem., July 19, 2002; 277(30): 27210 - 27216.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Grimmer, B. van Deurs, and K. Sandvig
Membrane ruffling and macropinocytosis in A431 cells require cholesterol
J. Cell Sci., July 15, 2002; 115(14): 2953 - 2962.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. Lamorte, I. Royal, M. Naujokas, and M. Park
Crk Adapter Proteins Promote an Epithelial-Mesenchymal-like Transition and Are Required for HGF-mediated Cell Spreading and Breakdown of Epithelial Adherens Junctions
Mol. Biol. Cell, May 1, 2002; 13(5): 1449 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. C. Brown, K. A. West, and C. E. Turner
Paxillin-dependent Paxillin Kinase Linker and p21-Activated Kinase Localization to Focal Adhesions Involves a Multistep Activation Pathway
Mol. Biol. Cell, May 1, 2002; 13(5): 1550 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
V. Matafora, S. Paris, S. Dariozzi, and I. d. Curtis
Molecular mechanisms regulating the subcellular localization of p95-APP1 between the endosomal recycling compartment and sites of actin organization at the cell surface
J. Cell Sci., March 14, 2002; 114(24): 4509 - 4520.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Wang and M. G. Kazanietz
Chimaerins, Novel Non-protein Kinase C Phorbol Ester Receptors, Associate with Tmp21-I (p23). EVIDENCE FOR A NOVEL ANCHORING MECHANISM INVOLVING THE CHIMAERIN C1 DOMAIN
J. Biol. Chem., February 1, 2002; 277(6): 4541 - 4550.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Laporte, F. Blondeau, A. Gansmuller, Y. Lutz, J.-L. Vonesch, and J.-L. Mandel
The PtdIns3P phosphatase myo