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Journal of Cell Science, Vol 113, Issue 15 2759-2769, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Differential distribution and defence involvement of antimicrobial peptides in mussel

G Mitta, F Vandenbulcke, T Noel, B Romestand, JC Beauvillain, M Salzet and P Roch
Laboratoire d'Endocrinologie des Annelides, Groupe de Neuroimmunite des Hirudinees, UPRES A 8017 CNRS, Universite des Sciences et Technologies de Lille, France.

In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, we revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.


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