spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krebs, D. L.
Right arrow Articles by Hilton, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krebs, D. L.
Right arrow Articles by Hilton, D. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 113, Issue 16 2813-2819, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

SOCS: physiological suppressors of cytokine signaling

DL Krebs and DJ Hilton
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia. krebs@wehi.edu.au

Cytokines regulate cellular behavior by interacting with receptors on the plasma membrane of target cells and activating intracellular signal transduction cascades such as the JAK-STAT pathway. Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine signaling. The SOCS family consists of eight proteins: SOCS1-SOCS7 and CIS, each of which contains a central Src-homology 2 (SH2) domain and a C-terminal SOCS box. The expression of CIS, SOCS1, SOCS2 and SOCS3 is induced in response to stimulation by a wide variety of cytokines, and overexpression of these proteins in cell lines results in inhibition of cytokine signaling. Thus, SOCS proteins appear to form part of a classical negative feedback loop. The analysis of mice lacking SOCS1 has revealed that it is critical in the negative regulation of IFN(gamma) signaling and in the differentiation of T cells. Additionally, the analysis of mouse embryos lacking SOCS3 suggests that SOCS3 negatively regulates fetal liver erythropoiesis, probably through its ability to modulate erythropoietin (Epo) signaling. Thus, the use of gene targeting has confirmed that SOCS proteins regulate cytokine signaling in a physiological setting.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
V. S. Ramgolam, Y. Sha, J. Jin, X. Zhang, and S. Markovic-Plese
IFN-{beta} Inhibits Human Th17 Cell Differentiation
J. Immunol., October 15, 2009; 183(8): 5418 - 5427.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P Caraceni, A M Pertosa, F Giannone, M Domenicali, I Grattagliano, A Principe, C Mastroleo, M G Perrelli, J Cutrin, F Trevisani, et al.
Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia
Gut, August 1, 2009; 58(8): 1135 - 1143.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-C. Tsai, J.-I. Kai, W.-C. Huang, C.-Y. Wang, Y. Wang, C.-L. Chen, Y.-T. Fang, Y.-S. Lin, R. Anderson, S.-H. Chen, et al.
Glycogen Synthase Kinase-3{beta} Facilitates IFN-{gamma}-Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2
J. Immunol., July 15, 2009; 183(2): 856 - 864.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. L. Christian, T. W. Collier, D. Zu, M. Licursi, C. M. Hough, and K. Hirasawa
Activated Ras/MEK Inhibits the Antiviral Response of Alpha Interferon by Reducing STAT2 Levels
J. Virol., July 1, 2009; 83(13): 6717 - 6726.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. Kageyama, K. Hanada, Y. Iwasaki, and T. Suda
Regulation and role of suppressor of cytokine signaling-3 in hypothalamic 4B cells
J. Endocrinol., June 1, 2009; 201(3): 369 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Fukuyama, T. Nakano, T. Matsumoto, B. G. G. Oliver, J. K. Burgess, A. Moriwaki, K. Tanaka, M. Kubo, T. Hoshino, H. Tanaka, et al.
Pulmonary Suppressor of Cytokine Signaling-1 Induced by IL-13 Regulates Allergic Asthma Phenotype
Am. J. Respir. Crit. Care Med., June 1, 2009; 179(11): 992 - 998.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-H. Kim, J. E. Kim, H.-Y. Liu, W. Cao, and J. Chen
Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway
J. Biol. Chem., January 11, 2008; 283(2): 708 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L. Feng, N. S. Allen, S. Simo, and J. A. Cooper
Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development
Genes & Dev., November 1, 2007; 21(21): 2717 - 2730.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. L. Barclay, S. T. Anderson, M. J. Waters, and J. D. Curlewis
Regulation of Suppressor of Cytokine Signaling 3 (SOC3) by Growth Hormone in Pro-B Cells
Mol. Endocrinol., October 1, 2007; 21(10): 2503 - 2515.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. L. Barclay, S. T. Anderson, M. J. Waters, and J. D. Curlewis
Characterization of the SOCS3 Promoter Response to Prostaglandin E2 in T47D Cells
Mol. Endocrinol., October 1, 2007; 21(10): 2516 - 2528.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Chattopadhyay, E. Tracy, P. Liang, O. Robledo, S. Rose-John, and H. Baumann
Interleukin-31 and Oncostatin-M Mediate Distinct Signaling Reactions and Response Patterns in Lung Epithelial Cells
J. Biol. Chem., February 2, 2007; 282(5): 3014 - 3026.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. Samardzija, A. Wenzel, S. Aufenberg, M. Thiersch, C. Reme, and C. Grimm
Differential role of Jak-STAT signaling in retinal degenerations
FASEB J, November 1, 2006; 20(13): 2411 - 2413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Z. Michaylira, J. G. Simmons, N. M. Ramocki, B. P. Scull, K. K. McNaughton, C. R. Fuller, and P. K. Lund
Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G472 - G481.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
E Larrea, R Aldabe, E Molano, C M Fernandez-Rodriguez, A Ametzazurra, M P Civeira, and J Prieto
Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies
Gut, August 1, 2006; 55(8): 1188 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Ahmed, G. Yumet, M. Shumate, C. H. Lang, P. Rotwein, and R. N. Cooney
Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytes
Am J Physiol Gastrointest Liver Physiol, July 1, 2006; 291(1): G35 - G44.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S. Assou, T. Anahory, V. Pantesco, T. Le Carrour, F. Pellestor, B. Klein, L. Reyftmann, H. Dechaud, J. De Vos, and S. Hamamah
The human cumulus-oocyte complex gene-expression profile
Hum. Reprod., July 1, 2006; 21(7): 1705 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
M J Walsh, J R Jonsson, M M Richardson, G M Lipka, D M Purdie, A D Clouston, and E E Powell
Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
Gut, April 1, 2006; 55(4): 529 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Gentili, M. J. Waters, and I. C. McMillen
Differential regulation of suppressor of cytokine signaling-3 in the liver and adipose tissue of the sheep fetus in late gestation
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1044 - R1051.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Qasimi, A. Ming-Lum, A. Ghanipour, C. J. Ong, M. E. Cox, J. Ihle, N. Cacalano, A. Yoshimura, and A. L-F. Mui
Divergent Mechanisms Utilized by SOCS3 to Mediate Interleukin-10 Inhibition of Tumor Necrosis Factor {alpha} and Nitric Oxide Production by Macrophages
J. Biol. Chem., March 10, 2006; 281(10): 6316 - 6324.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. Shi, B. Cave, K. Inouye, C. Bjorbaek, and J. S. Flier
Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance
Diabetes, March 1, 2006; 55(3): 699 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
V. E. MacRae, C. Farquharson, and S. F. Ahmed
The pathophysiology of the growth plate in juvenile idiopathic arthritis
Rheumatology, January 1, 2006; 45(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. Laubner, T. J. Kieffer, N. T. Lam, X. Niu, F. Jakob, and J. Seufert
Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic {beta}-Cells
Diabetes, December 1, 2005; 54(12): 3410 - 3417.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. L. Shumate, G. Yumet, T. A. Ahmed, and R. N. Cooney
Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G227 - G239.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
O. Sandra, I. Bataillon, P. Roux, J. Martal, G. Charpigny, P. Reinaud, P. Bolifraud, G. Germain, and K. H Al-Gubory
Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe
J. Mol. Endocrinol., June 1, 2005; 34(3): 637 - 644.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. S. Haring, G. A. Corbin, and J. T. Harty
Dynamic Regulation of IFN-{gamma} Signaling in Antigen-Specific CD8+ T Cells Responding to Infection
J. Immunol., June 1, 2005; 174(11): 6791 - 6802.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. B. Biddinger, K. Almind, M. Miyazaki, E. Kokkotou, J. M. Ntambi, and C. R. Kahn
Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome
Diabetes, May 1, 2005; 54(5): 1314 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Astolfi, L. Landuzzi, G. Nicoletti, C. De Giovanni, S. Croci, A. Palladini, S. Ferrini, M. Iezzi, P. Musiani, F. Cavallo, et al.
Gene Expression Analysis of Immune-Mediated Arrest of Tumorigenesis in a Transgenic Mouse Model of HER-2/neu-Positive Basal-Like Mammary Carcinoma
Am. J. Pathol., April 1, 2005; 166(4): 1205 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
D. R. Boverhof, E. Tam, A. S. Harney, R. B. Crawford, N. E. Kaminski, and T. R. Zacharewski
2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Suppressor of Cytokine Signaling 2 in Murine B Cells
Mol. Pharmacol., December 1, 2004; 66(6): 1662 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
B. Emanuelli, M. Glondu, C. Filloux, P. Peraldi, and E. Van Obberghen
The Potential Role of SOCS-3 in the Interleukin-1{beta}-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells
Diabetes, December 1, 2004; 53(suppl_3): S97 - S103.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. J. Park, K.-A. Ji, S.-B. Jeon, W.-H. Choi, I.-o. Han, H.-J. You, J.-H. Kim, I. Jou, and E.-H. Joe
Rac1 Contributes to Maximal Activation of STAT1 and STAT3 in IFN-{gamma}-Stimulated Rat Astrocytes
J. Immunol., November 1, 2004; 173(9): 5697 - 5703.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. L. Krebs, D. Metcalf, T. D. Merson, A. K. Voss, T. Thomas, J.-G. Zhang, S. Rakar, M. K. O'Bryan, T. A. Willson, E. M. Viney, et al.
Development of hydrocephalus in mice lacking SOCS7
PNAS, October 26, 2004; 101(43): 15446 - 15451.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Schick, E. J. Oakeley, N. E. Hynes, and A. Badache
TEL/ETV6 Is a Signal Transducer and Activator of Transcription 3 (Stat3)-induced Repressor of Stat3 Activity
J. Biol. Chem., September 10, 2004; 279(37): 38787 - 38796.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
W. Tong and H. F. Lodish
Lnk Inhibits Tpo-mpl Signaling and Tpo-mediated Megakaryocytopoiesis
J. Exp. Med., September 7, 2004; 200(5): 569 - 580.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Li, L. M. Gronning, P. O. Anderson, S. Li, K. Edvardsen, J. Johnston, D. Kioussis, P. R. Shepherd, and P. Wang
Insulin Induces SOCS-6 Expression and Its Binding to the p85 Monomer of Phosphoinositide 3-Kinase, Resulting in Improvement in Glucose Metabolism
J. Biol. Chem., August 13, 2004; 279(33): 34107 - 34114.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Shi, I. Tzameli, C. Bjorbaek, and J. S. Flier
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
J. Biol. Chem., August 13, 2004; 279(33): 34733 - 34740.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
T. Komazaki, H. Nagai, M. Emi, Y. Terada, A. Yabe, E. Jin, O. Kawanami, N. Konishi, Y. Moriyama, T. Naka, et al.
Hypermethylation-associated Inactivation of the SOCS-1 Gene, a JAK/STAT Inhibitor, in Human Pancreatic Cancers
Jpn. J. Clin. Oncol., April 1, 2004; 34(4): 191 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Woelfle and P. Rotwein
In vivo regulation of growth hormone-stimulated gene transcription by STAT5b
Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E393 - E401.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wormald and D. J. Hilton
Inhibitors of Cytokine Signal Transduction
J. Biol. Chem., January 9, 2004; 279(2): 821 - 824.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Matsukawa, K. Takeda, S. Kudo, T. Maeda, M. Kagayama, and S. Akira
Aberrant Inflammation and Lethality to Septic Peritonitis in Mice Lacking STAT3 in Macrophages and Neutrophils
J. Immunol., December 1, 2003; 171(11): 6198 - 6205.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. C. Calegari, R. M. N. Bezerra, M. A. Torsoni, A. S. Torsoni, K. G. Franchini, M. J. A. Saad, and L. A. Velloso
Suppressor of Cytokine Signaling 3 Is Induced by Angiotensin II in Heart and Isolated Cardiomyocytes, and Participates in Desensitization
Endocrinology, October 1, 2003; 144(10): 4586 - 4596.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Pal and A. Sahu
Leptin Signaling in the Hypothalamus during Chronic Central Leptin Infusion
Endocrinology, September 1, 2003; 144(9): 3789 - 3798.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Roes, B. K. Choi, and B. B. Cazac
Redirection of B cell responsiveness by transforming growth factor {beta} receptor
PNAS, June 10, 2003; 100(12): 7241 - 7246.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Gomez and N. C. Reich
Stimulation of Primary Human Endothelial Cell Proliferation by IFN
J. Immunol., June 1, 2003; 170(11): 5373 - 5381.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. J. Senn, P. J. Klover, I. A. Nowak, T. A. Zimmers, L. G. Koniaris, R. W. Furlanetto, and R. A. Mooney
Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes
J. Biol. Chem., April 11, 2003; 278(16): 13740 - 13746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. A. Denson, M. A. Held, R. K. Menon, S. J. Frank, A. F. Parlow, and D. L. Arnold
Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3
Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G646 - G654.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. V. Clevenger, P. A. Furth, S. E. Hankinson, and L. A. Schuler
The Role of Prolactin in Mammary Carcinoma
Endocr. Rev., February 1, 2003; 24(1): 1 - 27.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
C. J. Ormandy, M. Naylor, J. Harris, F. Robertson, N. D. Horseman, G. J. Lindeman, J. Visvader, and P. A. Kelly
Investigation of the Transcriptional Changes Underlying Functional Defects in the Mammary Glands of Prolactin Receptor Knockout Mice
Recent Prog. Horm. Res., January 1, 2003; 58(1): 297 - 323.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. J. Senn, P. J. Klover, I. A. Nowak, and R. A. Mooney
Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes
Diabetes, December 1, 2002; 51(12): 3391 - 3399.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ilangumaran, D. Finan, J. La Rose, J. Raine, A. Silverstein, P. De Sepulveda, and R. Rottapel
A Positive Regulatory Role for Suppressor of Cytokine Signaling 1 in IFN-{gamma}-Induced MHC Class II Expression in Fibroblasts
J. Immunol., November 1, 2002; 169(9): 5010 - 5020.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Rui, M. Yuan, D. Frantz, S. Shoelson, and M. F. White
SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2
J. Biol. Chem., October 25, 2002; 277(44): 42394 - 42398.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. J. Greenhalgh, D. Metcalf, A. L. Thaus, J. E. Corbin, R. Uren, P. O. Morgan, L. J. Fabri, J.-G. Zhang, H. M. Martin, T. A. Willson, et al.
Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling
J. Biol. Chem., October 18, 2002; 277(43): 40181 - 40184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Ishida, K. Hayashi, M. Hoshijima, T. Ogawa, S. Koga, Y. Miyatake, M. Kumegawa, T. Kimura, and T. Takeya
Large Scale Gene Expression Analysis of Osteoclastogenesis in Vitro and Elucidation of NFAT2 as a Key Regulator
J. Biol. Chem., October 18, 2002; 277(43): 41147 - 41156.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. D. Curlewis, S. P. Tam, P. Lau, D. H. L. Kusters, J. L. Barclay, S. T. Anderson, and M. J. Waters
A Prostaglandin F2{alpha} Analog Induces Suppressors of Cytokine Signaling-3 Expression in the Corpus Luteum of the Pregnant Rat: A Potential New Mechanism in Luteolysis
Endocrinology, October 1, 2002; 143(10): 3984 - 3993.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
D. S. Park, H. Lee, P. G. Frank, B. Razani, A. V. Nguyen, A. F. Parlow, R. G. Russell, J. Hulit, R. G. Pestell, and M. P. Lisanti
Caveolin-1-deficient Mice Show Accelerated Mammary Gland Development During Pregnancy, Premature Lactation, and Hyperactivation of the Jak-2/STAT5a Signaling Cascade
Mol. Biol. Cell, October 1, 2002; 13(10): 3416 - 3430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Yumet, M. L. Shumate, P. Bryant, C.-M. Lin, C. H. Lang, and R. N. Cooney
Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E472 - E481.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. L. Krebs, R. T. Uren, D. Metcalf, S. Rakar, J.-G. Zhang, R. Starr, D. P. De Souza, K. Hanzinikolas, J. Eyles, L. M. Connolly, et al.
SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation
Mol. Cell. Biol., July 1, 2002; 22(13): 4567 - 4578.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. J. Greenhalgh, P. Bertolino, S. L. Asa, D. Metcalf, J. E. Corbin, T. E. Adams, H. W. Davey, N. A. Nicola, D. J. Hilton, and W. S. Alexander
Growth Enhancement in Suppressor of Cytokine Signaling 2 (SOCS-2)-Deficient Mice Is Dependent on Signal Transducer and Activator of Transcription 5b (STAT5b)
Mol. Endocrinol., June 1, 2002; 16(6): 1394 - 1406.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. O. Leonard, K. Hannan, M. J. Burne, D. W. P. Lappin, P. Doran, P. Coleman, C. Stenson, C. T. Taylor, F. Daniels, C. Godson, et al.
15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1657 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. U. Mysorekar, M. A. Mulvey, S. J. Hultgren, and J. I. Gordon
Molecular Regulation of Urothelial Renewal and Host Defenses during Infection with Uropathogenic Escherichia coli
J. Biol. Chem., February 22, 2002; 277(9): 7412 - 7419.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Emanuelli, P. Peraldi, C. Filloux, C. Chavey, K. Freidinger, D. J. Hilton, G. S. Hotamisligil, and E. Van Obberghen
SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-alpha in the Adipose Tissue of Obese Mice
J. Biol. Chem., December 14, 2001; 276(51): 47944 - 47949.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. C. Pritchard, L. Hsu, J. Delrow, and P. S. Nelson
Project normal: Defining normal variance in mouse gene expression
PNAS, November 6, 2001; 98(23): 13266 - 13271.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Bousquet, V. Chesnokova, A. Kariagina, A. Ferrand, and S. Melmed
cAMP Neuropeptide Agonists Induce Pituitary Suppressor of Cytokine Signaling-3: Novel Negative Feedback Mechanism for Corticotroph Cytokine Action
Mol. Endocrinol., November 1, 2001; 15(11): 1880 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. Ling and H. Billig
PRL Receptor-Mediated Effects in Female Mouse Adipocytes: PRL Induces Suppressors of Cytokine Signaling Expression and Suppresses Insulin-Induced Leptin Production in Adipocytes in Vitro
Endocrinology, November 1, 2001; 142(11): 4880 - 4890.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. E. Karlsen, S. G. Ronn, K. Lindberg, J. Johannesen, E. D. Galsgaard, F. Pociot, J. H. Nielsen, T. Mandrup-Poulsen, J. Nerup, and N. Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
PNAS, September 26, 2001; (2001) 211445998.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. W. Roberts, L. Robb, S. Rakar, L. Hartley, L. Cluse, N. A. Nicola, D. Metcalf, D. J. Hilton, and W. S. Alexander
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
PNAS, July 31, 2001; 98(16): 9324 - 9329.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
G. J. Lindeman, S. Wittlin, H. Lada, M. J. Naylor, M. Santamaria, J.-G. Zhang, R. Starr, D. J. Hilton, W. S. Alexander, C. J. Ormandy, et al.
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice
Genes & Dev., July 1, 2001; 15(13): 1631 - 1636.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
I. Novoa, H. Zeng, H. P. Harding, and D. Ron
Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2{alpha}
J. Cell Biol., May 28, 2001; 153(5): 1011 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. E. Bell, A. Mavila, R. Salazar, K. J. Bayless, S. Kanagala, S. A. Maxwell, and G. E. Davis
Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling
J. Cell Sci., January 8, 2001; 114(15): 2755 - 2773.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. S. K. de Hooge, F. A. J. van de Loo, O. J. Arntz, and W. B. van den Berg
Involvement of IL-6, Apart from Its Role in Immunity, in Mediating a Chronic Response during Experimental Arthritis
Am. J. Pathol., December 1, 2000; 157(6): 2081 - 2091.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H Paradis and R. Gendron
LIF transduces contradictory signals on capillary outgrowth through induction of stat3 and (P41/43)MAP kinase
J. Cell Sci., January 12, 2000; 113(23): 4331 - 4339.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
C. Bjorbak, H. J. Lavery, S. H. Bates, R. K. Olson, S. M. Davis, J. S. Flier, and M. G. Myers Jr.
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985
J. Biol. Chem., December 15, 2000; 275(51): 40649 - 40657.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Mooney, J. Senn, S. Cameron, N. Inamdar, L. M. Boivin, Y. Shang, and R. W. Furlanetto
Suppressors of Cytokine Signaling-1 and -6 Associate with and Inhibit the Insulin Receptor. A POTENTIAL MECHANISM FOR CYTOKINE-MEDIATED INSULIN RESISTANCE
J. Biol. Chem., July 6, 2001; 276(28): 25889 - 25893.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Peraldi, C. Filloux, B. Emanuelli, D. J. Hilton, and E. Van Obberghen
Insulin Induces Suppressor of Cytokine Signaling-3 Tyrosine Phosphorylation through Janus-activated Kinase
J. Biol. Chem., June 29, 2001; 276(27): 24614 - 24620.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. G. Jegalian and H. Wu
Regulation of Socs Gene Expression by the Proto-oncoprotein GFI-1B. TWO ROUTES FOR STAT5 TARGET GENE INDUCTION BY ERYTHROPOIETIN
J. Biol. Chem., January 11, 2002; 277(3): 2345 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Metcalf, S. Mifsud, L. Di Rago, N. A. Nicola, D. J. Hilton, and W. S. Alexander
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
PNAS, January 22, 2002; 99(2): 943 - 948.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. E. Karlsen, S. G. Ronn, K. Lindberg, J. Johannesen, E. D. Galsgaard, F. Pociot, J. H. Nielsen, T. Mandrup-Poulsen, J. Nerup, and N. Billestrup
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity
PNAS, October 9, 2001; 98(21): 12191 - 12196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Chesnokova, A. Kariagina, and S. Melmed
Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation
Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1110 - E1118.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
I. Hamanaka, Y. Saito, H. Yasukawa, I. Kishimoto, K. Kuwahara, Y. Miyamoto, M. Harada, E. Ogawa, N. Kajiyama, N. Takahashi, et al.
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo
Circ. Res., April 13, 2001; 88(7): 727 - 732.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000