spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, D.
Right arrow Articles by Jiang, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, D.
Right arrow Articles by Jiang, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 113, Issue 17 2935-2940, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Roles of phospholipid signaling in chemoattractant-induced responses

D Wu, CK Huang and H Jiang
Department of Genetics and Developmental Biology and Department of Pathology, University of Connecticut, Farmington, CT 06030, USA.

Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamma) demonstrate that chemoattractants act through PLC-(beta)2 and PLC-(beta)3 to hydrolyze PtdIns(4,5)P(2) and through PI3K(gamma) to phosphorylate PtdIns(4,5)P(2) in mouse neutrophils. These studies also confirmed the importance and revealed new roles of these signaling pathways in chemoattractant-induced responses.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. Kasorn, P. Alcaide, Y. Jia, K. K. Subramanian, B. Sarraj, Y. Li, F. Loison, H. Hattori, L. E. Silberstein, W. F. Luscinskas, et al.
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals
J. Immunol., July 15, 2009; 183(2): 1032 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
D. M. Lehmann, A. M. P. B. Seneviratne, and A. V. Smrcka
Small Molecule Disruption of G Protein {beta}{gamma} Subunit Signaling Inhibits Neutrophil Chemotaxis and Inflammation
Mol. Pharmacol., February 1, 2008; 73(2): 410 - 418.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Partida-Sanchez, A. Gasser, R. Fliegert, C. C. Siebrands, W. Dammermann, G. Shi, B. J. Mousseau, A. Sumoza-Toledo, H. Bhagat, T. F. Walseth, et al.
Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction
J. Immunol., December 1, 2007; 179(11): 7827 - 7839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. L. Bach, Q.-M. Chen, W. T. Kerr, Y. Wang, L. Lian, J. K. Choi, D. Wu, M. G. Kazanietz, G. A. Koretzky, S. Zigmond, et al.
Phospholipase Cbeta Is Critical for T Cell Chemotaxis
J. Immunol., August 15, 2007; 179(4): 2223 - 2227.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Park, I. Park, D. Lee, Y. B. Choi, H. Lee, and Y. Yun
The adaptor protein Lad associates with the G protein {beta} subunit and mediates chemokine-dependent T-cell migration
Blood, June 15, 2007; 109(12): 5122 - 5128.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Masztalerz, I. S. Zeelenberg, Y. M. Wijnands, R. de Bruijn, A. M. Drager, H. Janssen, and E. Roos
Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration
J. Cell Sci., January 15, 2007; 120(2): 219 - 228.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. J. Hyduk, J. R. Chan,, S. T. Duffy, M. Chen, M. D. Peterson, T. K. Waddell, G. C. Digby, K. Szaszi, A. Kapus, and M. I. Cybulsky
Phospholipase C, calcium, and calmodulin are critical for {alpha}4{beta}1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants
Blood, January 1, 2007; 109(1): 176 - 184.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Boulven, S. Levasseur, S. Marois, G. Pare, E. Rollet-Labelle, and P. H. Naccache
Class IA Phosphatidylinositide 3-Kinases, rather than p110{gamma}, Regulate Formyl-Methionyl-Leucyl-Phenylalanine-Stimulated Chemotaxis and Superoxide Production in Differentiated Neutrophil-Like PLB-985 Cells.
J. Immunol., June 15, 2006; 176(12): 7621 - 7627.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. D. McCaig, A. M. Rajnicek, B. Song, and M. Zhao
Controlling Cell Behavior Electrically: Current Views and Future Potential
Physiol Rev, July 1, 2005; 85(3): 943 - 978.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. He, M. Nanamori, H. Sang, H. Yin, M. C. Dinauer, and R. D. Ye
Reconstitution of Chemotactic Peptide-Induced Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase Activation in Transgenic COS-phox Cells
J. Immunol., December 15, 2004; 173(12): 7462 - 7470.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. Hou, T. Kirchner, M. Singer, M. Matheis, D. Argentieri, and D. Cavender
In Vivo Activity of a Phospholipase C Inhibitor, 1-(6-((17{beta}-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in Acute and Chronic Inflammatory Reactions
J. Pharmacol. Exp. Ther., May 1, 2004; 309(2): 697 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Katagiri, M. Shimonaka, and T. Kinashi
Rap1-mediated Lymphocyte Function-associated Antigen-1 Activation by the T Cell Antigen Receptor Is Dependent on Phospholipase C-{gamma}1
J. Biol. Chem., March 19, 2004; 279(12): 11875 - 11881.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Scandella, Y. Men, D. F. Legler, S. Gillessen, L. Prikler, B. Ludewig, and M. Groettrup
CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2
Blood, March 1, 2004; 103(5): 1595 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-S. Bae, H. J. Yi, H.-Y. Lee, E. J. Jo, J. I. Kim, T. G. Lee, R. D. Ye, J.-Y. Kwak, and S. H. Ryu
Differential Activation of Formyl Peptide Receptor-Like 1 by Peptide Ligands
J. Immunol., December 15, 2003; 171(12): 6807 - 6813.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
L. Chen, C. Janetopoulos, Y. E. Huang, M. Iijima, J. Borleis, and P. N. Devreotes
Two Phases of Actin Polymerization Display Different Dependencies on PI(3,4,5)P3 Accumulation and Have Unique Roles during Chemotaxis
Mol. Biol. Cell, December 1, 2003; 14(12): 5028 - 5037.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Y.-S. Bae, J. C. Park, R. He, R. D. Ye, J.-Y. Kwak, P.-G. Suh, and S. Ho Ryu
Differential Signaling of Formyl Peptide Receptor-Like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or Lipoxin A4 in Human Neutrophils
Mol. Pharmacol., September 1, 2003; 64(3): 721 - 730.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Illenberger, C. Walliser, J. Strobel, O. Gutman, H. Niv, V. Gaidzik, Y. Kloog, P. Gierschik, and Y. I. Henis
Rac2 Regulation of Phospholipase C-beta 2 Activity and Mode of Membrane Interactions in Intact Cells
J. Biol. Chem., February 28, 2003; 278(10): 8645 - 8652.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
P. A. Iglesias and A. Levchenko
Modeling the Cell's Guidance System
Sci. Signal., September 3, 2002; 2002(148): re12 - re12.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. E. L. Stubbs, P. Schratl, A. Hartnell, T. J. Williams, B. A. Peskar, A. Heinemann, and I. Sabroe
Indomethacin Causes Prostaglandin D2-like and Eotaxin-like Selective Responses in Eosinophils and Basophils
J. Biol. Chem., July 12, 2002; 277(29): 26012 - 26020.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Liao, A.-K. Shirakawa, J. F. Foley, R. L. Rabin, and J. M. Farber
Human B Cells Become Highly Responsive to Macrophage-Inflammatory Protein-3{alpha}/CC Chemokine Ligand-20 After Cellular Activation Without Changes in CCR6 Expression or Ligand Binding
J. Immunol., May 15, 2002; 168(10): 4871 - 4880.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
G. Cicchetti, P. G. Allen, and M. Glogauer
CHEMOTACTIC SIGNALING PATHWAYS IN NEUTROPHILS: FROM RECEPTOR TO ACTIN ASSEMBLY
Critical Reviews in Oral Biology & Medicine, May 1, 2002; 13(3): 220 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Hannigan, L. Zhan, Z. Li, Y. Ai, D. Wu, and C.-K. Huang
Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
PNAS, March 19, 2002; 99(6): 3603 - 3608.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Flaishon, F. Lantner, R. Hershkoviz, Y. Levo, and I. Shachar
Low Levels of IFN-gamma Down-regulate the Integrin-dependent Adhesion of B Cells by Activating a Pathway That Interferes with Cytoskeleton Rearrangement
J. Biol. Chem., December 7, 2001; 276(50): 46701 - 46706.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000