spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukunaga, T.
Right arrow Articles by Tagaya, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukunaga, T.
Right arrow Articles by Tagaya, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Cell Science, Vol 113, Issue 18 3299-3307, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Implication of sphingolipid metabolism in the stability of the Golgi apparatus

T Fukunaga, M Nagahama, K Hatsuzawa, K Tani, A Yamamoto and M Tagaya
School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan.

We examined the effects of short chain and long chain ceramides on the stability of the Golgi apparatus. Short chain ceramides, C(2)- and C(6)-ceramides, blocked brefeldin A-induced Golgi disassembly without affecting the rapid release of Golgi coat proteins, whereas they did not inhibit brefeldin A-induced tubulation of endosomes. Both short chain ceramides also retarded Golgi disassembly induced by nordihydroguaiaretic acid and nocodazole, suggesting that they stabilize the Golgi apparatus. In contrast to short chain ceramides, natural long chain ceramides, when incorporated into cells or formed within cells upon treatment with sphingomyelinase or metabolic inhibitors, enhanced brefeldin A-induced Golgi disassembly. These results suggest that sphingolipid metabolism is implicated in the stability of the Golgi apparatus.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
T. Fugmann, A. Hausser, P. Schoffler, S. Schmid, K. Pfizenmaier, and M. A. Olayioye
Regulation of secretory transport by protein kinase D mediated phosphorylation of the ceramide transfer protein
J. Cell Biol., October 3, 2007; 178(1): 15 - 22.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Teuling, S. Ahmed, E. Haasdijk, J. Demmers, M. O. Steinmetz, A. Akhmanova, D. Jaarsma, and C. C. Hoogenraad
Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates
J. Neurosci., September 5, 2007; 27(36): 9801 - 9815.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
P. Moreau, F. Brandizzi, S. Hanton, L. Chatre, S. Melser, C. Hawes, and B. Satiat-Jeunemaitre
The plant ER-Golgi interface: a highly structured and dynamic membrane complex
J. Exp. Bot., January 1, 2007; 58(1): 49 - 64.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
D. Y. Hui and P. N. Howles
Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis
J. Lipid Res., December 1, 2002; 43(12): 2017 - 2030.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Ogretmen, B. J. Pettus, M. J. Rossi, R. Wood, J. Usta, Z. Szulc, A. Bielawska, L. M. Obeid, and Y. A. Hannun
Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line. ROLE FOR ENDOGENOUS CERAMIDE IN MEDIATING THE ACTION OF EXOGENOUS CERAMIDE
J. Biol. Chem., April 5, 2002; 277(15): 12960 - 12969.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Kirby, S. Zheng, P. Tso, P. N. Howles, and D. Y. Hui
Bile Salt-stimulated Carboxyl Ester Lipase Influences Lipoprotein Assembly and Secretion in Intestine. A PROCESS MEDIATED VIA CERAMIDE HYDROLYSIS
J. Biol. Chem., February 1, 2002; 277(6): 4104 - 4109.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2000