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Journal of Cell Science, Vol 113, Issue 2 183-192, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
J Somsel Rodman and A Wandinger-Ness
Department of Pathology, The University of New Mexico Health Sciences Center, School of Medicine, NE, Albuquerque, New Mexico 87131-5301, USA.
Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered in part by associated Rab GTPases. This review summarizes current knowledge about Rab GTPase functions in the endocytic pathways and provides insight into the regulation of Rab GTPase activity and mechanisms of Rab protein function. Functional assays have identified some Rab proteins that operate on individual pathways, but Rab proteins in several pathways remain controversial or have not been identified. Control of Rab GTPase activity is exerted through multiple levels of regulation. Significant new information pertaining to Rab protein function in regulating transport has emerged. Remarkably, Rab5 GTPase links budding, cytoskeletal transport and docking/fusion activities. This paradigm will most likely be generally applicable to other Rab GTPase pathways. Together with the cross-talk between different Rab proteins and their effectors, this may provide an integrated system for the general coordination of endocytic pathways to maintain organelle homeostasis.
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G. Zhu, J. Liu, S. Terzyan, P. Zhai, G. Li, and X. C. Zhang High Resolution Crystal Structures of Human Rab5a and Five Mutants with Substitutions in the Catalytically Important Phosphate-binding Loop J. Biol. Chem., January 17, 2003; 278(4): 2452 - 2460. [Abstract] [Full Text] [PDF]
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B. W. McColl, D. I. Graham, C. J. Weir, F. White, and K. Horsburgh Endocytic Pathway Alterations in Human Hippocampus after Global Ischemia and the Influence of APOE Genotype Am. J. Pathol., January 1, 2003; 162(1): 273 - 281. [Abstract] [Full Text] [PDF]
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T. Wang and W. Hong Interorganellar Regulation of Lysosome Positioning by the Golgi Apparatus through Rab34 Interaction with Rab-interacting Lysosomal Protein Mol. Biol. Cell, December 1, 2002; 13(12): 4317 - 4332. [Abstract] [Full Text] [PDF]
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J. Ramalho-Santos, G. Schatten, and R. D. Moreno Control of Membrane Fusion During Spermiogenesis and the Acrosome Reaction Biol Reprod, October 1, 2002; 67(4): 1043 - 1051. [Abstract] [Full Text] [PDF]
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K. Hattula, J. Furuhjelm, A. Arffman, and J. Peranen A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport Mol. Biol. Cell, September 1, 2002; 13(9): 3268 - 3280. [Abstract] [Full Text] [PDF]
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W. Wang and S. Ferro-Novick A Ypt32p Exchange Factor Is a Putative Effector of Ypt1p Mol. Biol. Cell, September 1, 2002; 13(9): 3336 - 3343. [Abstract] [Full Text] [PDF]
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A. Savina, M. Vidal, and M. I. Colombo The exosome pathway in K562 cells is regulated by Rab11 J. Cell Sci., June 15, 2002; 115(12): 2505 - 2515. [Abstract] [Full Text] [PDF]
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K. Croizet-Berger, C. Daumerie, M. Couvreur, P. J. Courtoy, and M.-F. van den Hove The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production PNAS, June 11, 2002; 99(12): 8277 - 8282. [Abstract] [Full Text] [PDF]
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J. H. Brumell, P. Tang, M. L. Zaharik, and B. B. Finlay Disruption of the Salmonella-Containing Vacuole Leads to Increased Replication of Salmonella enterica Serovar Typhimurium in the Cytosol of Epithelial Cells Infect. Immun., June 1, 2002; 70(6): 3264 - 3270. [Abstract] [Full Text] [PDF]
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 S. B. Sieczkarski and G. R. Whittaker Dissecting virus entry via endocytosis J. Gen. Virol., June 1, 2002; 83(7): 1535 - 1545. [Abstract] [Full Text] [PDF]
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A. J. Lindsay, A. G. Hendrick, G. Cantalupo, F. Senic-Matuglia, B. Goud, C. Bucci, and M. W. McCaffrey Rab Coupling Protein (RCP), a Novel Rab4 and Rab11 Effector Protein J. Biol. Chem., March 29, 2002; 277(14): 12190 - 12199. [Abstract] [Full Text] [PDF]
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R. Mesa, C. Salomon, M. Roggero, P. D. Stahl, and L. S. Mayorga Rab22a affects the morphology and function of the endocytic pathway J. Cell Sci., March 13, 2002; 114(22): 4041 - 4049. [Abstract] [Full Text] [PDF]
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 E. M. Bertram, R. G. Hawley, and T. H. Watts Overexpression of rab7 enhances the kinetics of antigen processing and presentation with MHC class II molecules in B cells Int. Immunol., March 1, 2002; 14(3): 309 - 318. [Abstract] [Full Text] [PDF]
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K. Saito, J. Murai, H. Kajiho, K. Kontani, H. Kurosu, and T. Katada A Novel Binding Protein Composed of Homophilic Tetramer Exhibits Unique Properties for the Small GTPase Rab5 J. Biol. Chem., January 25, 2002; 277(5): 3412 - 3418. [Abstract] [Full Text] [PDF]
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J. L. Seachrist, S. A. Laporte, L. B. Dale, A. V. Babwah, M. G. Caron, P. H. Anborgh, and S. S. G. Ferguson Rab5 Association with the Angiotensin II Type 1A Receptor Promotes Rab5 GTP Binding and Vesicular Fusion J. Biol. Chem., January 4, 2002; 277(1): 679 - 685. [Abstract] [Full Text]
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M. Kauppi, A. Simonsen, B. Bremnes, A. Vieira, J. Callaghan, H. Stenmark, and V. M. Olkkonen The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking J. Cell Sci., January 3, 2002; 115(5): 899 - 911. [Abstract] [Full Text] [PDF]
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L. A. Volpicelli, J. J. Lah, and A. I. Levey Rab5-dependent Trafficking of the m4 Muscarinic Acetylcholine Receptor to the Plasma Membrane, Early Endosomes, and Multivesicular Bodies J. Biol. Chem., December 7, 2001; 276(50): 47590 - 47598. [Abstract] [Full Text] [PDF]
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M. K. Magnusson, K. E. Meade, K. E. Brown, D. C. Arthur, L. A. Krueger, A. J. Barrett, and C. E. Dunbar Rabaptin-5 is a novel fusion partner to platelet-derived growth factor {beta} receptor in chronic myelomonocytic leukemia Blood, October 15, 2001; 98(8): 2518 - 2525. [Abstract] [Full Text] [PDF]
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W. Wunderlich, I. Fialka, D. Teis, A. Alpi, A. Pfeifer, R. G. Parton, F. Lottspeich, and L. A. Huber A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment J. Cell Biol., February 19, 2001; 152(4): 765 - 776. [Abstract] [Full Text] [PDF]
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N. Miyazawa, R. G. Crystal, and P. L. Leopold Adenovirus Serotype 7 Retention in a Late Endosomal Compartment prior to Cytosol Escape Is Modulated by Fiber Protein J. Virol., February 1, 2001; 75(3): 1387 - 1400. [Abstract] [Full Text]
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A. Rupper, B. Grove, and J. Cardelli Rab7 regulates phagosome maturation in Dictyostelium J. Cell Sci., January 7, 2001; 114(13): 2449 - 2460. [Abstract] [Full Text] [PDF]
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L. Gerez, K. Mohrmann, M. van Raak, M. Jongeneelen, X. Z. Zhou, K. P. Lu, and P. van der Sluijs Accumulation of rab4GTP in the Cytoplasm and Association with the Peptidyl-Prolyl Isomerase Pin1 during Mitosis Mol. Biol. Cell, July 1, 2000; 11(7): 2201 - 2211. [Abstract] [Full Text]
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J. Luzio, B. Rous, N. Bright, P. Pryor, B. Mullock, and R. Piper Lysosome-endosome fusion and lysosome biogenesis J. Cell Sci., January 5, 2000; 113(9): 1515 - 1524. [Abstract] [PDF]
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H. Kipp, N. Pichetshote, and I. M. Arias Transporters on Demand. INTRAHEPATIC POOLS OF CANALICULAR ATP BINDING CASSETTE TRANSPORTERS IN RAT LIVER J. Biol. Chem., March 2, 2001; 276(10): 7218 - 7224. [Abstract] [Full Text] [PDF]
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