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Journal of Cell Science, Vol 113, Issue 20 3563-3571, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
S Liu, DA Calderwood and MH Ginsberg
Department of Vascular Biology, VB-2, The Scripps Research Institute, La Jolla, CA 92037, USA. ginsberg@scripps.edu
Integrins are a large family of cell surface receptors that mediate cell adhesion and influence migration, signal transduction, and gene expression. The cytoplasmic domains of integrins play a pivotal role in these integrin-mediated cellular functions. Through interaction with the cytoskeleton, signaling molecules, and other cellular proteins, integrin cytoplasmic domains transduce signals from both the outside and inside of the cell and regulate integrin-mediated biological functions. Identification and functional analyses of integrin cytoplasmic domain-binding proteins have been pursued intensively. In recent years, more cellular proteins have been reported to directly interact with integrin cytoplasmic domains and some of these interactions may play important roles in integrin-mediated biological responses. Integrin (&bgr;) chains, for example, interact with actin-binding proteins (e.g. talin and filamin), which form mechanical links to the cytoskeleton. These and other proteins (e.g. FAK, ILK and novel proteins such as TAP20) might also link integrins to signaling mechanisms and, in some cases (e.g. JAB1) mediate integrin-dependent gene regulation.
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|
|
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|
|
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|
|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
|
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|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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 |
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 |
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|
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|
 |
|
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|
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|
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|
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|
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D. M. Rose, S. Liu, D. G. Woodside, J. Han, D. D. Schlaepfer, and M. H. Ginsberg Paxillin Binding to the {alpha}4 Integrin Subunit Stimulates LFA-1 (Integrin {alpha}L{beta}2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2 J. Immunol., June 15, 2003; 170(12): 5912 - 5918. [Abstract] [Full Text] [PDF]
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J. Na, M. Marsden, and D. W. DeSimone Differential regulation of cell adhesive functions by integrin {alpha} subunit cytoplasmic tails in vivo J. Cell Sci., June 1, 2003; 116(11): 2333 - 2343. [Abstract] [Full Text] [PDF]
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P. A. Ritch, S. L. Carroll, and H. Sontheimer Neuregulin-1 Enhances Motility and Migration of Human Astrocytic Glioma Cells J. Biol. Chem., May 30, 2003; 278(23): 20971 - 20978. [Abstract] [Full Text] [PDF]
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R. Pankov, E. Cukierman, K. Clark, K. Matsumoto, C. Hahn, B. Poulin, and K. M. Yamada Specific beta 1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A J. Biol. Chem., May 9, 2003; 278(20): 18671 - 18681. [Abstract] [Full Text] [PDF]
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C. Perrault, P. Mangin, M. Santer, M.-J. Baas, S. Moog, S. L. Cranmer, I. Pikovski, D. Williamson, S. P. Jackson, J.-P. Cazenave, et al. Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex Blood, May 1, 2003; 101(9): 3477 - 3484. [Abstract] [Full Text] [PDF]
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D. A. Calderwood, Y. Fujioka, J. M. de Pereda, B. Garcia-Alvarez, T. Nakamoto, B. Margolis, C. J. McGlade, R. C. Liddington, and M. H. Ginsberg Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling PNAS, March 4, 2003; 100(5): 2272 - 2277. [Abstract] [Full Text] [PDF]
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 C. A. Lipinski, N. L. Tran, C. Bay, J. Kloss, W. S. McDonough, C. Beaudry, M. E. Berens, and J. C. Loftus Differential Role of Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase in Determining Glioblastoma Migration and Proliferation Mol. Cancer Res., March 1, 2003; 1(5): 323 - 332. [Abstract] [Full Text] [PDF]
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R. R. Hantgan, D. S. Lyles, T. C. Mallett, M. Rocco, C. Nagaswami, and J. W. Weisel Ligand Binding Promotes the Entropy-driven Oligomerization of Integrin alpha IIbbeta 3 J. Biol. Chem., January 24, 2003; 278(5): 3417 - 3426. [Abstract] [Full Text] [PDF]
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K. A. DeMali, C. A. Barlow, and K. Burridge Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion J. Cell Biol., December 9, 2002; 159(5): 881 - 891. [Abstract] [Full Text] [PDF]
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A. L. Berrier, R. Martinez, G. M. Bokoch, and S. E. LaFlamme The integrin {beta} tail is required and sufficient to regulate adhesion signaling to Rac1 J. Cell Sci., November 15, 2002; 115(22): 4285 - 4291. [Abstract] [Full Text] [PDF]
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F. Besta, S. Massberg, K. Brand, E. Muller, S. Page, S. Gruner, M. Lorenz, K. Sadoul, W. Kolanus, E. Lengyel, et al. Role of {beta}3-endonexin in the regulation of NF-{kappa}B-dependent expression of urokinase-type plasminogen activator receptor J. Cell Sci., October 15, 2002; 115(20): 3879 - 3888. [Abstract] [Full Text] [PDF]
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R.C. Liddington and M.H. Ginsberg Integrin activation takes shape J. Cell Biol., September 3, 2002; 158(5): 833 - 839. [Abstract] [Full Text] [PDF]
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K. M. T. de Bruyn, S. Rangarajan, K. A. Reedquist, C. G. Figdor, and J. L. Bos The Small GTPase Rap1 Is Required for Mn2+- and Antibody-induced LFA-1- and VLA-4-mediated Cell Adhesion J. Biol. Chem., August 9, 2002; 277(33): 29468 - 29476. [Abstract] [Full Text] [PDF]
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E. Hirsch, L. Barberis, M. Brancaccio, O. Azzolino, D. Xu, J. M. Kyriakis, L. Silengo, F. G. Giancotti, G. Tarone, R. Fassler, et al. Defective Rac-mediated proliferation and survival after targeted mutation of the {beta}1 integrin cytodomain J. Cell Biol., April 29, 2002; 157(3): 481 - 492. [Abstract] [Full Text] [PDF]
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A. Obergfell, K. Eto, A. Mocsai, C. Buensuceso, S. L. Moores, J. S. Brugge, C. A. Lowell, and S. J. Shattil Coordinate interactions of Csk, Src, and Syk kinases with {alpha}IIb{beta}3 initiate integrin signaling to the cytoskeleton J. Cell Biol., April 15, 2002; 157(2): 265 - 275. [Abstract] [Full Text] [PDF]
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D. J. Blake, A. Weir, S. E. Newey, and K. E. Davies Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle Physiol Rev, April 1, 2002; 82(2): 291 - 329. [Abstract] [Full Text] [PDF]
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D. G. Woodside Dancing with Multiple Partners Sci. Signal., March 19, 2002; 2002(124): pe14 - pe14. [Abstract] [Full Text] [PDF]
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E. I. Deryugina, B. I. Ratnikov, T. I. Postnova, D. V. Rozanov, and A. Y. Strongin Processing of Integrin alpha v Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase J. Biol. Chem., March 15, 2002; 277(12): 9749 - 9756. [Abstract] [Full Text] [PDF]
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E. A. Turley, P. W. Noble, and L. Y. W. Bourguignon Signaling Properties of Hyaluronan Receptors J. Biol. Chem., February 8, 2002; 277(7): 4589 - 4592. [Full Text] [PDF]
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D. Vossmeyer, W. Hofmann, K. Loster, W. Reutter, and K. Danker Phospholipase Cgamma Binds alpha 1beta 1 Integrin and Modulates alpha 1beta 1 Integrin-specific Adhesion J. Biol. Chem., February 8, 2002; 277(7): 4636 - 4643. [Abstract] [Full Text] [PDF]
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A. van der Flier, I. Kuikman, D. Kramer, D. Geerts, M. Kreft, T. Takafuta, S. S. Shapiro, and A. Sonnenberg Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin {beta} subunits J. Cell Biol., January 21, 2002; 156(2): 361 - 376. [Abstract] [Full Text] [PDF]
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A. Gustavsson, A. Armulik, C. Brakebusch, R. Fassler, S. Johansson, and M. Fallman Role of the {beta}1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia J. Cell Sci., January 7, 2002; 115(13): 2669 - 2678. [Abstract] [Full Text] [PDF]
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T. Ishii, E. Satoh, and M. Nishimura Integrin-linked Kinase Controls Neurite Outgrowth in N1E-115 Neuroblastoma Cells J. Biol. Chem., November 9, 2001; 276(46): 42994 - 43003. [Abstract] [Full Text] [PDF]
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D. G. Stupack, X. S. Puente, S. Boutsaboualoy, C. M. Storgard, and D. A. Cheresh Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins J. Cell Biol., October 29, 2001; 155(3): 459 - 470. [Abstract] [Full Text] [PDF]
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S. F. Retta, G. Cassara, M. D'Amato, R. Alessandro, M. Pellegrino, S. Degani, G. De Leo, L. Silengo, and G. Tarone Cross Talk between beta 1 and alpha V Integrins: beta 1 Affects beta 3 mRNA Stability Mol. Biol. Cell, October 1, 2001; 12(10): 3126 - 3138. [Abstract] [Full Text] [PDF]
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 N. Hogg and B. Leitinger Shape and shift changes related to the function of leukocyte integrins LFA-1 and Mac-1 J. Leukoc. Biol., June 1, 2001; 69(6): 893 - 898. [Abstract] [Full Text] [PDF]
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