|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 113, Issue 20 3639-3647, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
FM Spagnoli, C Cicchini, M Tripodi and MC Weiss
Unite de Genetique de la Differenciation, URA 1773 du CNRS, Institut Pasteur, 75724 Paris Cedex 15, France.
MMH (Met murine hepatocyte) liver cells derived from transgenic mice expressing a truncated constitutively active form of human c-Met are non-transformed immortalized cell lines. We have previously shown that they harbor: (1) epithelial cells that express the liver-enriched transcription factors HNF4 and HNF1(alpha), and that can be stably induced by FGF1 to express liver functions, and (2) fibroblast-like bi-potential palmate cells that can differentiate into bile duct-like structures in Matrigel cultures, or into epithelial cells competent to express hepatic functions. Low concentrations of TGF(beta) have been found to inhibit growth and differentiation of MMH cells. The factor stabilized the palmate cell phenotype, and it provoked epithelial cells to acquire palmate-like morphological characteristics, in parallel with down-regulation of expression of HNF4 and HNF1(alpha) and activation of Snail transcripts. The effects of TGF(beta) were dominant if it was added with FGF1, but the effects on differentiation were abrogated if cells had been pre-treated with FGF1. This work identifies TGF(beta) as a factor that could be implicated in maintaining bi-potential precursor cells in the liver, FGF1 as one that could over-ride the TGF(beta) effects and Snail as a candidate for mediation of the signal.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Choi, S. Y. Park, and C.-K. Joo Transforming Growth Factor-{beta}1 Represses E-Cadherin Production via Slug Expression in Lens Epithelial Cells Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2708 - 2718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Evans, R. C. Russell, O. Roche, T. N. Burry, J. E. Fish, V. W. K. Chow, W. Y. Kim, A. Saravanan, M. A. Maynard, M. L. Gervais, et al. VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail Mol. Cell. Biol., January 1, 2007; 27(1): 157 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yang, X. Pan, W. Lei, J. Wang, J. Shi, F. Li, and J. Song Regulation of Transforming Growth Factor-{beta}1-Induced Apoptosis and Epithelial-to-Mesenchymal Transition by Protein Kinase A and Signal Transducers and Activators of Transcription 3. Cancer Res., September 1, 2006; 66(17): 8617 - 8624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Peiro, M. Escriva, I. Puig, M. J. Barbera, N. Dave, N. Herranz, M. J. Larriba, M. Takkunen, C. Franci, A. Munoz, et al. Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res., January 1, 2006; 34(7): 2077 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Clotman, P. Jacquemin, N. Plumb-Rudewiez, C. E. Pierreux, P. Van der Smissen, H. C. Dietz, P. J. Courtoy, G. G. Rousseau, and F. P. Lemaigre Control of liver cell fate decision by a gradient of TGF{beta} signaling modulated by Onecut transcription factors Genes & Dev., August 15, 2005; 19(16): 1849 - 1854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Barrallo-Gimeno and M. A. Nieto The Snail genes as inducers of cell movement and survival: implications in development and cancer Development, July 15, 2005; 132(14): 3151 - 3161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yamasaki, T. Sekimoto, T. Ohkubo, T. Douchi, Y. Nagata, M. Ozawa, and Y. Yoneda Zinc finger domain of Snail functions as a nuclear localization signal for importin {beta}-mediated nuclear import pathway Genes Cells, May 1, 2005; 10(5): 455 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maeda, K. R. Johnson, and M. J. Wheelock Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition J. Cell Sci., March 1, 2005; 118(5): 873 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Peinado, F. Marin, E. Cubillo, H.-J. Stark, N. Fusenig, M. A. Nieto, and A. Cano Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo J. Cell Sci., June 1, 2004; 117(13): 2827 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vega, A. V. Morales, O. H. Ocana, F. Valdes, I. Fabregat, and M. A. Nieto Snail blocks the cell cycle and confers resistance to cell death Genes & Dev., May 15, 2004; 18(10): 1131 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Margulies, M. Blanchette, NISC Comparative Sequencing Program, D. Haussler, and E. D. Green Identification and Characterization of Multi-Species Conserved Sequences Genome Res., December 1, 2003; 13(12): 2507 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Peinado, M. Quintanilla, and A. Cano Transforming Growth Factor {beta}-1 Induces Snail Transcription Factor in Epithelial Cell Lines: MECHANISMS FOR EPITHELIAL MESENCHYMAL TRANSITIONS J. Biol. Chem., May 30, 2003; 278(23): 21113 - 21123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Valdes, A. M. Alvarez, A. Locascio, S. Vega, B. Herrera, M. Fernandez, M. Benito, M. A. Nieto, and I. Fabregat The Epithelial Mesenchymal Transition Confers Resistance to the Apoptotic Effects of Transforming Growth Factor {beta} in Fetal Rat Hepatocytes Mol. Cancer Res., November 1, 2002; 1(1): 68 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ansuini, C. Cicchini, A. Nicosia, M. Tripodi, R. Cortese, and A. Luzzago Biotin-tagged cDNA expression libraries displayed on lambda phage: a new tool for the selection of natural protein ligands Nucleic Acids Res., August 1, 2002; 30(15): e78 - e78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gotzmann, H. Huber, C. Thallinger, M. Wolschek, B. Jansen, R. Schulte-Hermann, H. Beug, and W. Mikulits Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-{beta}1 and Ha-Ras: steps towards invasiveness J. Cell Sci., March 15, 2002; 115(6): 1189 - 1202. [Abstract] [Full Text] [PDF]
|
|
