|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 113, Issue 22 3889-3896, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
N Rhind and P Russell
Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Recent work on the mechanisms of DNA damage and replication cell cycle checkpoints has revealed great similarity between the checkpoint pathways of organisms as diverse as yeasts, flies and humans. However, there are differences in the ways these organisms regulate their cell cycles. To connect the conserved checkpoint pathways with various cell cycle targets requires an adaptable link that can target different cell cycle components in different organisms. The Chk1 and Cds1 protein kinases, downstream effectors in the checkpoint pathways, seem to play just such roles. Perhaps more surprisingly, the two kinases not only have different targets in different organisms but also seem to respond to different signals in different organisms. So, whereas in fission yeast Chk1 is required for the DNA damage checkpoint and Cds1 is specifically involved in the replication checkpoint, their roles seem to be shuffled in metazoans.
This article has been cited by other articles:
|
|
 |
|
  M. Segurado and J. F.X. Diffley Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks Genes & Dev., July 1, 2008; 22(13): 1816 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Ansbach, C. Noguchi, I. W. Klansek, M. Heidlebaugh, T. M. Nakamura, and E. Noguchi RFCCtf18 and the Swi1-Swi3 Complex Function in Separate and Redundant Pathways Required for the Stabilization of Replication Forks to Facilitate Sister Chromatid Cohesion in Schizosaccharomyces pombe Mol. Biol. Cell, February 1, 2008; 19(2): 595 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shikata, F. Ishikawa, and J. Kanoh Tel2 Is Required for Activation of the Mrc1-mediated Replication Checkpoint J. Biol. Chem., February 23, 2007; 282(8): 5346 - 5355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Noguchi and E. Noguchi Sap1 Promotes the Association of the Replication Fork Protection Complex With Chromatin and Is Involved in the Replication Checkpoint in Schizosaccharomyces pombe Genetics, February 1, 2007; 175(2): 553 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shiromizu, H. Goto, Y. Tomono, J. Bartek, G. Totsukawa, A. Inoko, M. Nakanishi, F. Matsumura, and M. Inagaki Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells, May 1, 2006; 11(5): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pebernard, J. Wohlschlegel, W. H. McDonald, J. R. Yates III, and M. N. Boddy The nse5-nse6 dimer mediates DNA repair roles of the smc5-smc6 complex. Mol. Cell. Biol., March 1, 2006; 26(5): 1617 - 1630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lubelsky, N. Reuven, and Y. Shaul Autorepression of Rfx1 Gene Expression: Functional Conservation from Yeast to Humans in Response to DNA Replication Arrest Mol. Cell. Biol., December 1, 2005; 25(23): 10665 - 10673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Purdy, L. Uyetake, M. G. Cordeiro, and T. T. Su Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1) J. Cell Sci., August 1, 2005; 118(15): 3305 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I. de Vries, L. Uyetake, W. Lemstra, J. F. Brunsting, T. T. Su, H. H. Kampinga, and O. C. M. Sibon Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable J. Cell Sci., May 1, 2005; 118(9): 1833 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sommariva, T. K. Pellny, N. Karahan, S. Kumar, J. A. Huberman, and J. Z. Dalgaard Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 Are Components of a Novel S-Phase Response Pathway to Alkylation Damage Mol. Cell. Biol., April 1, 2005; 25(7): 2770 - 2784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bimbo, Y. Jia, S. L. Poh, R. K. M. Karuturi, N. den Elzen, X. Peng, L. Zheng, M. O'Connell, E. T. Liu, M. K. Balasubramanian, et al. Systematic Deletion Analysis of Fission Yeast Protein Kinases Eukaryot. Cell, April 1, 2005; 4(4): 799 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Ou, P.-H. Chung, T.-P. Sun, and S.-Y. Shieh p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation Mol. Biol. Cell, April 1, 2005; 16(4): 1684 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Zachos, M. D. Rainey, and D. A. F. Gillespie Chk1-Dependent S-M Checkpoint Delay in Vertebrate Cells Is Linked to Maintenance of Viable Replication Structures Mol. Cell. Biol., January 15, 2005; 25(2): 563 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Gomez, V. T. Angeles, and S. L. Forsburg A Screen for Schizosaccharomyces pombe Mutants Defective in Rereplication Identifies New Alleles of rad4+, cut9+ and psf2+ Genetics, January 1, 2005; 169(1): 77 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Karagiannis, A. Bimbo, S. Rajagopalan, J. Liu, and M. K. Balasubramanian The Nuclear Kinase Lsk1p Positively Regulates the Septation Initiation Network and Promotes the Successful Completion of Cytokinesis in Response to Perturbation of the Actomyosin Ring in Schizosaccharomyces pombe Mol. Biol. Cell, January 1, 2005; 16(1): 358 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao and P. Russell DNA Binding Domain in the Replication Checkpoint Protein Mrc1 of Schizosaccharomyces pombe J. Biol. Chem., December 17, 2004; 279(51): 53023 - 53027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. McSherry and P. R. Mueller Xenopus Cds1 Is Regulated by DNA-Dependent Protein Kinase and ATR during the Cell Cycle Checkpoint Response to Double-Stranded DNA Ends Mol. Cell. Biol., November 15, 2004; 24(22): 9968 - 9985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pebernard, W. H. McDonald, Y. Pavlova, J. R. Yates III, and M. N. Boddy Nse1, Nse2, and a Novel Subunit of the Smc5-Smc6 Complex, Nse3, Play a Crucial Role in Meiosis Mol. Biol. Cell, November 1, 2004; 15(11): 4866 - 4876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Caporali, S. Falcinelli, G. Starace, M. T. Russo, E. Bonmassar, J. Jiricny, and S. D'Atri DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System Mol. Pharmacol., September 1, 2004; 66(3): 478 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanaka and P. Russell Cds1 Phosphorylation by Rad3-Rad26 Kinase Is Mediated by Forkhead-associated Domain Interaction with Mrc1 J. Biol. Chem., July 30, 2004; 279(31): 32079 - 32086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lehmann, S. Katayama, C. Harrison, S. Dhut, K. Kitamura, N. McDonald, and T. Toda Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint Genes Cells, May 1, 2004; 9(5): 367 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Loegering, S. J. H. Arlander, J. Hackbarth, B. T. Vroman, P. Roos-Mattjus, K. M. Hopkins, H. B. Lieberman, L. M. Karnitz, and S. H. Kaufmann Rad9 Protects Cells from Topoisomerase Poison-induced Cell Death J. Biol. Chem., April 30, 2004; 279(18): 18641 - 18647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Katsuragi and N. Sagata Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation Mol. Biol. Cell, April 1, 2004; 15(4): 1680 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Blankley and D. Lydall A domain of Rad9 specifically required for activation of Chk1 in budding yeast J. Cell Sci., February 1, 2004; 117(4): 601 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. H. Arlander, A. K. Eapen, B. T. Vroman, R. J. McDonald, D. O. Toft, and L. M. Karnitz Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress J. Biol. Chem., December 26, 2003; 278(52): 52572 - 52577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gonzalez, C. Prives, and C. Cordon-Cardo p73{alpha} Regulation by Chk1 in Response to DNA Damage Mol. Cell. Biol., November 15, 2003; 23(22): 8161 - 8171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bondar, E. V. Mirkin, D. S. Ucker, W. E. Walden, S. M. Mirkin, and P. Raychaudhuri Schizosaccharomyces pombe Ddb1 Is functionally Linked to the Replication Checkpoint Pathway J. Biol. Chem., September 26, 2003; 278(39): 37006 - 37014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chahwan, T. M. Nakamura, S. Sivakumar, P. Russell, and N. Rhind The Fission Yeast Rad32 (Mre11)-Rad50-Nbs1 Complex Is Required for the S-Phase DNA Damage Checkpoint Mol. Cell. Biol., September 15, 2003; 23(18): 6564 - 6573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Boddy, P. Shanahan, W. H. McDonald, A. Lopez-Girona, E. Noguchi, J. R. Yates III, and P. Russell Replication Checkpoint Kinase Cds1 Regulates Recombinational Repair Protein Rad60 Mol. Cell. Biol., August 15, 2003; 23(16): 5939 - 5946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lambert, S. J. Mason, L. J. Barber, J. A. Hartley, J. A. Pearce, A. M. Carr, and P. J. McHugh Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links Mol. Cell. Biol., July 1, 2003; 23(13): 4728 - 4737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Roos-Mattjus, K. M. Hopkins, A. J. Oestreich, B. T. Vroman, K. L. Johnson, S. Naylor, H. B. Lieberman, and L. M. Karnitz Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling J. Biol. Chem., June 27, 2003; 278(27): 24428 - 24437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishimi, Y. Komamura-Kohno, H.-J. Kwon, K. Yamada, and M. Nakanishi Identification of MCM4 as a Target of the DNA Replication Block Checkpoint System J. Biol. Chem., June 27, 2003; 278(27): 24644 - 24650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Perez-Hidalgo, S. Moreno, and P. A. San-Segundo Regulation of meiotic progression by the meiosis-specific checkpoint kinase Mek1 in fission yeast J. Cell Sci., January 15, 2003; 116(2): 259 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kai and T. S.-F. Wang Checkpoint activation regulates mutagenic translesion synthesis Genes & Dev., January 1, 2003; 17(1): 64 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimada, P. Pasero, and S. M. Gasser ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase Genes & Dev., December 15, 2002; 16(24): 3236 - 3252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Roos-Mattjus, B. T. Vroman, M. A. Burtelow, M. Rauen, A. K. Eapen, and L. M. Karnitz Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) Chromatin Association Is an Early Checkpoint Signaling Event J. Biol. Chem., November 8, 2002; 277(46): 43809 - 43812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Williams and J. R. McIntosh mcl1+, the Schizosaccharomyces pombe Homologue of CTF4, Is Important for Chromosome Replication, Cohesion, and Segregation Eukaryot. Cell, October 1, 2002; 1(5): 758 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Peters, C. DeLuca, A. Hirao, V. Stambolic, J. Potter, L. Zhou, J. Liepa, B. Snow, S. Arya, J. Wong, et al. Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila PNAS, August 20, 2002; 99(17): 11305 - 11310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Kohn, N. D. Ruth, M. K. Brown, M. Livingstone, and A. Eastman Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation J. Biol. Chem., July 12, 2002; 277(29): 26553 - 26564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Marchetti, S. Kumar, E. Hartsuiker, M. Maftahi, A. M. Carr, G. A. Freyer, W. C. Burhans, and J. A. Huberman A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway PNAS, May 28, 2002; 99(11): 7472 - 7477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. O'Neill, L. Giarratani, P. Chen, L. Iyer, C.-H. Lee, M. Bobiak, F. Kanai, B.-B. Zhou, J. H. Chung, and G. A. Rathbun Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach J. Biol. Chem., May 3, 2002; 277(18): 16102 - 16115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Katayama, K. Kitamura, A. Lehmann, O. Nikaido, and T. Toda Fission Yeast F-box Protein Pof3 Is Required for Genome Integrity and Telomere Function Mol. Biol. Cell, January 1, 2002; 13(1): 211 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Chakraverty, J. M. Kearsey, T. J. Oakley, M. Grenon, M.-A. de la Torre Ruiz, N. F. Lowndes, and I. D. Hickson Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint Mol. Cell. Biol., November 1, 2001; 21(21): 7150 - 7162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Lee, S. H. Kim, D. W. Bell, D. C. R. Wahrer, T. A. Schiripo, M. M. Jorczak, D. C. Sgroi, J. E. Garber, F. P. Li, K. E. Nichols, et al. Destabilization of CHK2 by a Missense Mutation Associated with Li-Fraumeni Syndrome Cancer Res., November 1, 2001; 61(22): 8062 - 8067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Liang and S. L. Forsburg Characterization of Schizosaccharomyces pombe mcm7+ and cdc23+ (MCM10) and Interactions With Replication Checkpoints Genetics, October 1, 2001; 159(2): 471 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weinreich, C. Liang, H.-H. Chen, and B. Stillman Inaugural Article: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle PNAS, September 25, 2001; 98(20): 11211 - 11217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lopez-Girona, K. Tanaka, X.-B. Chen, B. A. Baber, C. H. McGowan, and P. Russell Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast PNAS, September 5, 2001; (2001) 191557598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. MacQueen and A. M. Villeneuve Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2 Genes & Dev., July 1, 2001; 15(13): 1674 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, D. Liu, Y. Wang, J. Qin, and S. J. Elledge Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function Genes & Dev., June 1, 2001; 15(11): 1361 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kai, H. Tanaka, and T. S.-F. Wang Fission Yeast Rad17 Associates with Chromatin in Response to Aberrant Genomic Structures Mol. Cell. Biol., May 15, 2001; 21(10): 3289 - 3301. [Abstract] [Full Text]
|
|
|
|
|
|
N. Rhind and P. Russell Roles of the Mitotic Inhibitors Wee1 and Mik1 in the G2 DNA Damage and Replication Checkpoints Mol. Cell. Biol., March 1, 2001; 21(5): 1499 - 1508. [Abstract] [Full Text]
|
|
|
|
|
|
K. Marheineke and O. Hyrien Aphidicolin Triggers a Block to Replication Origin Firing in Xenopus Egg Extracts J. Biol. Chem., May 11, 2001; 276(20): 17092 - 17100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cliby, K. A. Lewis, K. K. Lilly, and S. H. Kaufmann S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function J. Biol. Chem., January 4, 2002; 277(2): 1599 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Shann and M.-T. Hsu Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat J. Biol. Chem., December 21, 2001; 276(52): 48863 - 48870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lopez-Girona, K. Tanaka, X.-B. Chen, B. A. Baber, C. H. McGowan, and P. Russell Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast PNAS, September 25, 2001; 98(20): 11289 - 11294. [Abstract] [Full Text] [PDF]
|
|
