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Journal of Cell Science, Vol 113, Issue 22 3897-3905, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
JD Norton
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. jnorton@essex.ac.uk
The ubiquitously expressed family of ID helix-loop-helix (HLH) proteins function as dominant negative regulators of basic HLH (bHLH) transcriptional regulators that drive cell lineage commitment and differentiation in metazoa. Recent data from cell line and in vivo studies have implicated the functions of ID proteins in other cellular processes besides negative regulation of cell differentiation. ID proteins play key roles in the regulation of lineage commitment, cell fate decisions and in the timing of differentiation during neurogenesis, lymphopoiesis and neovascularisation (angiogenesis). They are essential for embryogenesis and for cell cycle progression, and they function as positive regulators of cell proliferation. ID proteins also possess pro-apoptotic properties in a variety of cell types and function as cooperating or dominant oncoproteins in immortalisation of rodent and human cells and in tumour induction in Id-transgenic mice. In several human tumour types, the expression of ID proteins is deregulated, and loss- and gain-of-function studies implicate ID functions in the regulation of tumour growth, vascularisation, invasiveness and metastasis. More recent biochemical studies have also revealed an emerging 'molecular promiscuity' of mammalian ID proteins: they directly interact with and modulate the activities of several other families of transcriptional regulator, besides bHLH proteins.
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|
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|
|
|
|
|
|
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|
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|
|
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|
|
|
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|
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|
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|
|
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|
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|
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|
|
|
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|
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|
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|
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|
|
 |
|
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|
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|
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|
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|
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J.-Y. Kim, K. Chu, H.-J. Kim, H.-A Seong, K.-C. Park, S. Sanyal, J. Takeda, H. Ha, M. Shong, M.-J. Tsai, et al. Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD Mol. Endocrinol., April 1, 2004; 18(4): 776 - 790. [Abstract] [Full Text] [PDF]
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H. Zhang and I. Rosdahl Ultraviolet A and B differently induce intracellular protein expression in human skin melanocytes--a speculation of separate pathways in initiation of melanoma Carcinogenesis, December 1, 2003; 24(12): 1929 - 1934. [Abstract] [Full Text] [PDF]
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|
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P. M. Siegel, W. Shu, and J. Massague Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-{beta}-mediated Epithelial Cell Growth Suppression J. Biol. Chem., September 12, 2003; 278(37): 35444 - 35450. [Abstract] [Full Text] [PDF]
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 J. J. Buzzard, N. G. Wreford, and J. R. Morrison Thyroid Hormone, Retinoic Acid, and Testosterone Suppress Proliferation and Induce Markers of Differentiation in Cultured Rat Sertoli Cells Endocrinology, September 1, 2003; 144(9): 3722 - 3731. [Abstract] [Full Text] [PDF]
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 J. Stinson, T. Inoue, P. Yates, A. Clancy, J. D. Norton, and A. D. Sharrocks Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs Nucleic Acids Res., August 15, 2003; 31(16): 4717 - 4728. [Abstract] [Full Text] [PDF]
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 S. E. Alway, H. Degens, G. Krishnamurthy, and A. Chaudhrai Denervation Stimulates Apoptosis But Not Id2 Expression in Hindlimb Muscles of Aged Rats J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2003; 58(8): B687 - 697. [Abstract] [Full Text] [PDF]
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T. G. Shepherd and M. W. Nachtigal Identification of a Putative Autocrine Bone Morphogenetic Protein-Signaling Pathway in Human Ovarian Surface Epithelium and Ovarian Cancer Cells Endocrinology, August 1, 2003; 144(8): 3306 - 3314. [Abstract] [Full Text] [PDF]
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 J. Tang, G. M. Gordon, M. G. Muller, M. Dahiya, and K. E. Foreman Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial Cells J. Virol., May 15, 2003; 77(10): 5975 - 5984. [Abstract] [Full Text] [PDF]
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S. Miyake, Y. Yanagisawa, and Y. Yuasa A Novel EID-1 Family Member, EID-2, Associates with Histone Deacetylases and Inhibits Muscle Differentiation J. Biol. Chem., May 2, 2003; 278(19): 17060 - 17065. [Abstract] [Full Text] [PDF]
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L. R. Howe, O. Watanabe, J. Leonard, and A. M. C. Brown Twist Is Up-Regulated in Response to Wnt1 and Inhibits Mouse Mammary Cell Differentiation Cancer Res., April 15, 2003; 63(8): 1906 - 1913. [Abstract] [Full Text] [PDF]
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R. C. Chambers, P. Leoni, N. Kaminski, G. J. Laurent, and R. A. Heller Global Expression Profiling of Fibroblast Responses to Transforming Growth Factor-{beta}1 Reveals the Induction of Inhibitor of Differentiation-1 and Provides Evidence of Smooth Muscle Cell Phenotypic Switching Am. J. Pathol., February 1, 2003; 162(2): 533 - 546. [Abstract] [Full Text] [PDF]
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 S. E. Alway, J. K. Martyn, J. Ouyang, A. Chaudhrai, and Z. S. Murlasits Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R540 - R549. [Abstract] [Full Text] [PDF]
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 K. A. Strait, B. Dabbas, E. H. Hammond, C. T. Warnick, S. J. Ilstrup, and C. D. Ford Cell Cycle Blockade and Differentiation of Ovarian Cancer Cells by the Histone Deacetylase Inhibitor Trichostatin A Are Associated with Changes in p21, Rb, and Id Proteins Mol. Cancer Ther., November 1, 2002; 1(13): 1181 - 1190. [Abstract] [Full Text] [PDF]
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 A. K. Gupta and B. C. Kone USF-1 and USF-2 trans-repress IL-1beta -induced iNOS transcription in mesangial cells Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1065 - C1072. [Abstract] [Full Text] [PDF]
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G. Lopez-Carballo, L. Moreno, S. Masia, P. Perez, and D. Barettino Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Retinoic Acid Is Required for Neural Differentiation of SH-SY5Y Human Neuroblastoma Cells J. Biol. Chem., July 5, 2002; 277(28): 25297 - 25304. [Abstract] [Full Text] [PDF]
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S. E. Alway, H. Degens, G. Krishnamurthy, and C. A. Smith Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats Am J Physiol Cell Physiol, July 1, 2002; 283(1): C66 - C76. [Abstract] [Full Text] [PDF]
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 D A Mann and D E Smart Transcriptional regulation of hepatic stellate cell activation Gut, June 1, 2002; 50(6): 891 - 896. [Abstract] [Full Text] [PDF]
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X. S. Ouyang, X. Wang, M.-T. Ling, H. L. Wong, S. W. Tsao, and Y.C. Wong Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16INK4a/pRB pathway Carcinogenesis, May 1, 2002; 23(5): 721 - 725. [Abstract] [Full Text] [PDF]
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A. Jogi, P. Persson, A. Grynfeld, S. Pahlman, and H. Axelson Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation J. Biol. Chem., March 8, 2002; 277(11): 9118 - 9126. [Abstract] [Full Text] [PDF]
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O. Korchynskyi and P. ten Dijke Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter J. Biol. Chem., February 8, 2002; 277(7): 4883 - 4891. [Abstract] [Full Text] [PDF]
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T. Lopez-Rovira, E. Chalaux, J. Massague, J. L. Rosa, and F. Ventura Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation of Id1 Gene J. Biol. Chem., January 25, 2002; 277(5): 3176 - 3185. [Abstract] [Full Text] [PDF]
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A. Lasorella, R. Boldrini, C. Dominici, A. Donfrancesco, Y. Yokota, A. Inserra, and A. Iavarone Id2 Is Critical for Cellular Proliferation and Is the Oncogenic Effector of N-Myc in Human Neuroblastoma Cancer Res., January 1, 2002; 62(1): 301 - 306. [Abstract] [Full Text] [PDF]
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J. W. Wilson, R. W. Deed, T. Inoue, M. Balzi, A. Becciolini, P. Faraoni, C. S. Potten, and J. D. Norton Expression of Id Helix-Loop-Helix Proteins in Colorectal Adenocarcinoma Correlates with p53 Expression and Mitotic Index Cancer Res., December 1, 2001; 61(24): 8803 - 8810. [Abstract] [Full Text] [PDF]
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 P. Oettgen Transcriptional Regulation of Vascular Development Circ. Res., August 31, 2001; 89(5): 380 - 388. [Abstract] [Full Text] [PDF]
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D. Polsky, A. Z. Young, K. J. Busam, and R. M. Alani The Transcriptional Repressor of p16/Ink4a, Id1, Is Up-Regulated in Early Melanomas Cancer Res., August 1, 2001; 61(16): 6008 - 6011. [Abstract] [Full Text] [PDF]
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R. M. Alani, A. Z. Young, and C. B. Shifflett Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a PNAS, June 20, 2001; (2001) 141235398. [Abstract] [Full Text] [PDF]
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B. A. Christy A Role for an Alternatively Spliced Id3 Isoform in Vascular Lesions? Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 727 - 728. [Full Text] [PDF]
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E. C. Roberts, R. W. Deed, T. Inoue, J. D. Norton, and A. D. Sharrocks Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding Mol. Cell. Biol., January 15, 2001; 21(2): 524 - 533. [Abstract] [Full Text]
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 S. E. Bell, A. Mavila, R. Salazar, K. J. Bayless, S. Kanagala, S. A. Maxwell, and G. E. Davis Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling J. Cell Sci., January 8, 2001; 114(15): 2755 - 2773. [Abstract] [Full Text] [PDF]
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S. P. Rockman, S. A. Currie, M. Ciavarella, E. Vincan, C. Dow, R. J. S. Thomas, and W. A. Phillips Id2 Is a Target of the beta -Catenin/T Cell Factor Pathway in Colon Carcinoma J. Biol. Chem., November 21, 2001; 276(48): 45113 - 45119. [Abstract] [Full Text] [PDF]
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R. M. Alani, A. Z. Young, and C. B. Shifflett Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a PNAS, July 3, 2001; 98(14): 7812 - 7816. [Abstract] [Full Text] [PDF]
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