|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 113, Issue 23 4143-4149, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
J Li, GI Lee, SR Van Doren and JC Walker
Division of Biological Sciences and Department of Biochemistry, University of Missouri-Columbia, Columbia, MO 65211, USA.
The forkhead-associated (FHA) domain is a phosphopeptide-binding domain first identified in a group of forkhead transcription factors but is present in a wide variety of proteins from both prokaryotes and eukaryotes. In yeast and human, many proteins containing an FHA domain are found in the nucleus and involved in DNA repair, cell cycle arrest, or pre-mRNA processing. In plants, the FHA domain is part of a protein that is localized to the plasma membrane and participates in the regulation of receptor-like protein kinase signaling pathways. Recent studies show that a functional FHA domain consists of 120-140 amino acid residues, which is significantly larger than the sequence motif first described. Although FHA domains do not exhibit extensive sequence similarity, they share similar secondary and tertiary structures, featuring a sandwich of two anti-parallel (beta)-sheets. One intriguing finding is that FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine, distinguishing them from other well-studied phosphoprotein-binding domains. The diversity of proteins containing FHA domains and potential differences in binding specificities suggest the FHA domain is involved in coordinating diverse cellular processes.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. A. E. Ali, R. M. Jukes, L. H. Pearl, and A. W. Oliver Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK Nucleic Acids Res., April 1, 2009; 37(5): 1701 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mahajan, C. Yuan, H. Lee, E. S.-W. Chen, P.-Y. Wu, and M.-D. Tsai Structure and Function of the Phosphothreonine-Specific FHA Domain Sci. Signal., December 23, 2008; 1(51): re12 - re12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miyahara, T. A. Hirani, M. Oakes, A. Kereszt, B. Kobe, M. A. Djordjevic, and P. M. Gresshoff Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro J. Biol. Chem., September 12, 2008; 283(37): 25381 - 25391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Yu, L. Bi, B. Zheng, L. Ji, D. Chevalier, M. Agarwal, V. Ramachandran, W. Li, T. Lagrange, J. C. Walker, et al. The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis PNAS, July 22, 2008; 105(29): 10073 - 10078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Guillemain, E. Ma, S. Mauger, S. Miron, R. Thai, R. Guerois, F. Ochsenbein, and M.-C. Marsolier-Kergoat Mechanisms of Checkpoint Kinase Rad53 Inactivation after a Double-Strand Break in Saccharomyces cerevisiae Mol. Cell. Biol., May 1, 2007; 27(9): 3378 - 3389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Morris, D. Chevalier, and J. C. Walker DAWDLE, a Forkhead-Associated Domain Gene, Regulates Multiple Aspects of Plant Development Plant Physiology, July 1, 2006; 141(3): 932 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Gruneberg, R. Neef, X. Li, E. H.Y. Chan, R. B. Chalamalasetty, E. A. Nigg, and F. A. Barr KIF14 and citron kinase act together to promote efficient cytokinesis J. Cell Biol., January 30, 2006; 172(3): 363 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Guarguaglini, P. I. Duncan, Y. D. Stierhof, T. Holmstrom, S. Duensing, and E. A. Nigg The Forkhead-associated Domain Protein Cep170 Interacts with Polo-like Kinase 1 and Serves as a Marker for Mature Centrioles Mol. Biol. Cell, March 1, 2005; 16(3): 1095 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jelsbak, M. Givskov, and D. Kaiser Enhancer-binding proteins with a forkhead-associated domain and the {sigma}54 regulon in Myxococcus xanthus fruiting body development PNAS, February 22, 2005; 102(8): 3010 - 3015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Ea, L. Sun, J.-I. Inoue, and Z. J. Chen TIFA activates I{kappa}B kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 PNAS, October 26, 2004; 101(43): 15318 - 15323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bieganowski, K. Shilinski, P. N. Tsichlis, and C. Brenner Cdc123 and Checkpoint Forkhead Associated with RING Proteins Control the Cell Cycle by Controlling eIF2{gamma} Abundance J. Biol. Chem., October 22, 2004; 279(43): 44656 - 44666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takano, S. Adachi, M. Okuno, Y. Muto, T. Yoshioka, R. Matsushima-Nishiwaki, H. Tsurumi, K. Ito, S. L. Friedman, H. Moriwaki, et al. The RING Finger Protein, RNF8, Interacts with Retinoid X Receptor {alpha} and Enhances Its Transcription-stimulating Activity J. Biol. Chem., April 30, 2004; 279(18): 18926 - 18934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Pike, S. Yongkiettrakul, M.-D. Tsai, and J. Heierhorst Mdt1, a Novel Rad53 FHA1 Domain-Interacting Protein, Modulates DNA Damage Tolerance and G2/M Cell Cycle Progression in Saccharomyces cerevisiae Mol. Cell. Biol., April 1, 2004; 24(7): 2779 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cheutin, M.-F. O'Donohue, A. Beorchia, C. Klein, H. Kaplan, and D. Ploton Three-dimensional Organization of pKi-67: A Comparative Fluorescence and Electron Tomography Study Using Fluoronanogold J. Histochem. Cytochem., November 1, 2003; 51(11): 1411 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Reynolds, B. J. Shi, C. McLean, F. Katsis, B. Kemp, and S. Dalton Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clbkinase activity: a mechanism for CLB cluster gene activation Genes & Dev., July 15, 2003; 17(14): 1789 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Toyota, Y. Sasaki, A. Satoh, K. Ogi, T. Kikuchi, H. Suzuki, H. Mita, N. Tanaka, F. Itoh, J.-P. J. Issa, et al. Epigenetic inactivation of CHFR in human tumors PNAS, June 24, 2003; 100(13): 7818 - 7823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takatsuna, H. Kato, J. Gohda, T. Akiyama, A. Moriya, Y. Okamoto, Y. Yamagata, M. Otsuka, K. Umezawa, K. Semba, et al. Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor Signaling J. Biol. Chem., March 28, 2003; 278(14): 12144 - 12150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Kemp and G. F. Sprague Jr. Far3 and Five Interacting Proteins Prevent Premature Recovery from Pheromone Arrest in the Budding Yeast Saccharomyces cerevisiae Mol. Cell. Biol., March 1, 2003; 23(5): 1750 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. I. Bashkirov, E. V. Bashkirova, E. Haghnazari, and W.-D. Heyer Direct Kinase-to-Kinase Signaling Mediated by the FHA Phosphoprotein Recognition Domain of the Dun1 DNA Damage Checkpoint Kinase Mol. Cell. Biol., February 15, 2003; 23(4): 1441 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kim, J.-W. Ahn, K. Song, K.-H. Paek, and H.-S. Pai Forkhead-associated Domains of the Tobacco NtFHA1 Transcription Activator and the Yeast Fhl1 Forkhead Transcription Factor Are Functionally Conserved J. Biol. Chem., October 4, 2002; 277(41): 38781 - 38790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Bensen, S. G. Filler, and J. Berman A Forkhead Transcription Factor Is Important for True Hyphal as well as Yeast Morphogenesis in Candida albicans Eukaryot. Cell, October 1, 2002; 1(5): 787 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boudrez, M. Beullens, E. Waelkens, W. Stalmans, and M. Bollen Phosphorylation-dependent Interaction between the Splicing Factors SAP155 and NIPP1 J. Biol. Chem., August 23, 2002; 277(35): 31834 - 31841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, L. M. Tsvetkov, and D. F. Stern Chk2 Activation and Phosphorylation-Dependent Oligomerization Mol. Cell. Biol., June 15, 2002; 22(12): 4419 - 4432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hammet, B. L. Pike, and J. Heierhorst Posttranscriptional Regulation of the RAD5 DNA Repair Gene by the Dun1 Kinase and the Pan2-Pan3 Poly(A)-Nuclease Complex Contributes to Survival of Replication Blocks J. Biol. Chem., June 14, 2002; 277(25): 22469 - 22474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Moustakas, S. Souchelnytskyi, and C.-H. Heldin Smad regulation in TGF-{beta} signal transduction J. Cell Sci., March 14, 2002; 114(24): 4359 - 4369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. W. Cohen Protein phosphatase 1 - targeted in many directions J. Cell Sci., January 15, 2002; 115(2): 241 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gómez-Gómez, Z. Bauer, and T. Boller Both the Extracellular Leucine-Rich Repeat Domain and the Kinase Activity of FLS2 Are Required for Flagellin Binding and Signaling in Arabidopsis PLANT CELL, May 1, 2001; 13(5): 1155 - 1163. [Abstract] [Full Text]
|
|
|
|
|
|
M. Takagi, M. Sueishi, T. Saiwaki, A. Kametaka, and Y. Yoneda A Novel Nucleolar Protein, NIFK, Interacts with the Forkhead Associated Domain of Ki-67 Antigen in Mitosis J. Biol. Chem., June 29, 2001; 276(27): 25386 - 25391. [Abstract] [Full Text] [PDF]
|
|
