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Journal of Cell Science, Vol 113, Issue 23 4157-4163, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
X Le Goff, F Motegi, E Salimova, I Mabuchi and V Simanis
Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), Switzerland.
In order to identify additional components important for cell division in the fission yeast Schizosaccharomyces pombe we have screened a bank of conditional cold-sensitive mutants for cytokinesis defects. One of these mutants showed a delay in cell cleavage, and strong genetic interactions with other genes implicated in medial ring formation. Cloning of the corresponding gene indicates that it encodes a protein with significant homology to the regulatory light chain of non-muscle myosins. We have named the gene rlc1 (regulatory light chain 1). The gene is not essential for division, but null mutants display a cell cleavage defect and form an aberrant F-actin ring. Two myosin-II heavy chains have been identified in fission yeast: Co-immunoprecipitation experiments indicate that rlc1p associates more strongly with myo3p than myo2p.
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