|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 113, Issue 6 911-919, Copyright © 2000 by Company of Biologists
COMMENTARIES |
J Behrens
Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Str. 10, Germany. jbehren@mdc-berlin.de.
The Wnt signal transduction pathway regulates various aspects of embryonal development and is involved in cancer formation. Wnts induce the stabilisation of cytosolic (beta)-catenin, which then associates with TCF transcription factors to regulate expression of Wnt-target genes. At various levels the Wnt pathway is subject to cross-regulation by other components. Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK1 and the MAP kinase NLK counteract Wnt signalling. In particular, homologues of TAK1 and NLK, MOM-4 and LIT-1, negatively regulate Wnt-controlled cell fate decision in the early Caenorhabditis elegans embryo. Moreover, TAK1 activates NLK, which phosphorylates TCFs bound to (beta)-catenin. This blocks nuclear localization and DNA binding of TCFs. Since TAK1 is activated by TGF-(beta) and various cytokines, it might provide an entry point for regulation of the Wnt system by other pathways. In addition, alterations in TAK1-NLK might play a role in cancer.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Pai, D. Dunlap, J. Qing, I. Mohtashemi, K. Hotzel, and D. M. French Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating {beta}-Catenin Signaling Cancer Res., July 1, 2008; 68(13): 5086 - 5095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. A. Zeng, M. Rahnama, S. Wang, W. Sosu-Sedzorme, and E. M. Verheyen Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation Development, June 1, 2007; 134(11): 2061 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Rebholz-Schuhmann, H. Kirsch, M. Arregui, S. Gaudan, M. Riethoven, and P. Stoehr EBIMed--text crunching to gather facts for proteins from Medline Bioinformatics, January 15, 2007; 23(2): e237 - e244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, H. C. Whetstone, A. Youn, P. Nadesan, E. C. Y. Chow, A. C. Lin, and B. A. Alman beta-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation J. Biol. Chem., January 5, 2007; 282(1): 526 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. O. Ward, D. A. Delker, S. D. Hester, S.-F. Thai, D. C. Wolf, J. W. Allen, and S. Nesnow Transcriptional Profiles in Liver from Mice Treated with Hepatotumorigenic and Nonhepatotumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil Toxicol Pathol, December 1, 2006; 34(7): 863 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Rottinger, J. Croce, G. Lhomond, L. Besnardeau, C. Gache, and T. Lepage Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo Development, November 1, 2006; 133(21): 4341 - 4353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Cheon, Q. Wei, A. Gurung, A. Youn, T. Bright, R. Poon, H. Whetstone, A. Guha, and B. A. Alman Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing FASEB J, April 1, 2006; 20(6): 692 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Edlund, S. Y. Lee, S. Grimsby, S. Zhang, P. Aspenstrom, C.-H. Heldin, and M. Landstrom Interaction between Smad7 and {beta}-Catenin: Importance for Transforming Growth Factor {beta}-Induced Apoptosis Mol. Cell. Biol., February 15, 2005; 25(4): 1475 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Thorpe and R. T. Moon nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development Development, June 15, 2004; 131(12): 2899 - 2909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tuli, S. Tuli, S. Nandi, X. Huang, P. A. Manner, W. J. Hozack, K. G. Danielson, D. J. Hall, and R. S. Tuan Transforming Growth Factor-{beta}-mediated Chondrogenesis of Human Mesenchymal Progenitor Cells Involves N-cadherin and Mitogen-activated Protein Kinase and Wnt Signaling Cross-talk J. Biol. Chem., October 17, 2003; 278(42): 41227 - 41236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Wood, V. L. Nelson, C. Ho, E. Jansen, C. Y. Wang, M. Urbanek, J. M. McAllister, S. Mosselman, and J. F. Strauss III The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis J. Biol. Chem., July 11, 2003; 278(29): 26380 - 26390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. I. Dorsky, M. Itoh, R. T. Moon, and A. Chitnis Two tcf3 genes cooperate to pattern the zebrafish brain Development, May 1, 2003; 130(9): 1937 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schohl and F. Fagotto {beta}-catenin, MAPK and Smad signaling during early Xenopus development Development, January 1, 2002; 129(1): 37 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Hsu, R. Shakya, and F. Costantini Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice J. Cell Biol., December 10, 2001; 155(6): 1055 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vidal, R. S. Khush, F. Leulier, P. Tzou, M. Nakamura, and B. Lemaitre Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-{kappa}B-dependent innate immune responses Genes & Dev., August 1, 2001; 15(15): 1900 - 1912. [Abstract] [Full Text] [PDF]
|
|
