|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 114, Issue 1 111-118, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
V Noe, B Fingleton, K Jacobs, HC Crawford, S Vermeulen, W Steelant, E Bruyneel, LM Matrisian and M Mareel
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
The function of many transmembrane molecules can be altered by cleavage and subsequent release of their ectodomains. We have investigated ectodomain cleavage of the cell-cell adhesion and signal-transducing molecule E-cadherin. The E-cadherin ectodomain is constitutively shed from the surface of MCF-7 and MDCKts.srcC12 cells in culture. Release of the 80 kDa soluble E-cadherin fragment is stimulated by phorbol-12-myristate-13-acetate and is inhibited by overexpression of the tissue inhibitor of metalloproteinases-2. The metalloproteinases matrilysin and stromelysin-1 both cleave E-cadherin at the cell surface and release sE-CAD into the medium. The soluble E-cadherin fragment thus released inhibits E-cadherin functions in a paracrine way, as indicated by induction of invasion into collagen type I and inhibition of E-cadherin-dependent cell aggregation. Our results, therefore, suggest a novel mechanism by which metalloproteinases can influence invasion.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Roy, J. Yang, and M. A. Moses Matrix Metalloproteinases As Novel Biomarkers and Potential Therapeutic Targets in Human Cancer J. Clin. Oncol., November 1, 2009; 27(31): 5287 - 5297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Ra, S. Harju-Baker, F. Zhang, R. J. Linhardt, C. L. Wilson, and W. C. Parks Control of Promatrilysin (MMP7) Activation and Substrate-specific Activity by Sulfated Glycosaminoglycans J. Biol. Chem., October 9, 2009; 284(41): 27924 - 27932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bauer, A. Dowejko, A.-K. Bosserhoff, T.E. Reichert, and R. Josef Bauer P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by GSK-3beta-mediated Snail phosphorylation Carcinogenesis, October 1, 2009; 30(10): 1781 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.-Y. FU, M.-F. HOU, S.-F. YANG, S.-C. HUANG, and W.-Y. LEE Cobalt Chloride-induced Hypoxia Modulates the Invasive Potential and Matrix Metalloproteinases of Primary and Metastatic Breast Cancer Cells Anticancer Res, August 1, 2009; 29(8): 3131 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zheng, J. G. Lyons, T. K. Tan, Y. Wang, T.-T. Hsu, D. Min, L. Succar, G. K. Rangan, M. Hu, B. R. Henderson, et al. Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells Am. J. Pathol., August 1, 2009; 175(2): 580 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. A. Kohutek, C. G. diPierro, G. T. Redpath, and I. M. Hussaini ADAM-10-Mediated N-Cadherin Cleavage Is Protein Kinase C-{alpha} Dependent and Promotes Glioblastoma Cell Migration J. Neurosci., April 8, 2009; 29(14): 4605 - 4615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. McCusker, H. Cousin, R. Neuner, and D. Alfandari Extracellular Cleavage of Cadherin-11 by ADAM Metalloproteases Is Essential for Xenopus Cranial Neural Crest Cell Migration Mol. Biol. Cell, January 1, 2009; 20(1): 78 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Klessner, B. V. Desai, E. V. Amargo, S. Getsios, and K. J. Green EGFR and ADAMs Cooperate to Regulate Shedding and Endocytic Trafficking of the Desmosomal Cadherin Desmoglein 2 Mol. Biol. Cell, January 1, 2009; 20(1): 328 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Higashi, M. Oeda, K. Yamamoto, and K. Miyazaki Identification of Amino Acid Residues of Matrix Metalloproteinase-7 Essential for Binding to Cholesterol Sulfate J. Biol. Chem., December 19, 2008; 283(51): 35735 - 35744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Helguero, K. Lindberg, C. Gardmo, T. Schwend, J.-A. Gustafsson, and L.-A. Haldosen Different Roles of Estrogen Receptors {alpha} and {beta} in the Regulation of E-Cadherin Protein Levels in a Mouse Mammary Epithelial Cell Line Cancer Res., November 1, 2008; 68(21): 8695 - 8704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.I. Marin-Briggiler, M.F. Veiga, M.L. Matos, M.F. Gonzalez Echeverria, L.I. Furlong, and M.H. Vazquez-Levin Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization Mol. Hum. Reprod., October 1, 2008; 14(10): 561 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Najy, K. C. Day, and M. L. Day The Ectodomain Shedding of E-cadherin by ADAM15 Supports ErbB Receptor Activation J. Biol. Chem., June 27, 2008; 283(26): 18393 - 18401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Cowden Dahl, J. Symowicz, Y. Ning, E. Gutierrez, D. A. Fishman, B. P. Adley, M. S. Stack, and L. G. Hudson Matrix Metalloproteinase 9 Is a Mediator of Epidermal Growth Factor-Dependent E-Cadherin Loss in Ovarian Carcinoma Cells Cancer Res., June 15, 2008; 68(12): 4606 - 4613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ortega, A. Moran, C. de Juan, C. Frias, S. Hernandez, J.-A. Lopez-Asenjo, A. Sanchez-Pernaute, A. Torres, P. Iniesta, and M. Benito Differential Wnt Pathway Gene Expression and E-Cadherin Truncation in Sporadic Colorectal Cancers with and without Microsatellite Instability Clin. Cancer Res., February 15, 2008; 14(4): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sengupta and T. T. MacDonald The Role of Matrix Metalloproteinases in Stromal/Epithelial Interactions in the Gut Physiology, December 1, 2007; 22(6): 401 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wu, K.-J. Rhee, M. Zhang, A. Franco, and C. L. Sears Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and {gamma}-secretase-dependent E-cadherin cleavage J. Cell Sci., June 1, 2007; 120(11): 1944 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Hojilla, I. Kim, Z. Kassiri, J. E. Fata, H. Fang, and R. Khokha Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3 J. Cell Sci., March 15, 2007; 120(6): 1050 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Symowicz, B. P. Adley, K. J. Gleason, J. J. Johnson, S. Ghosh, D. A. Fishman, L. G. Hudson, and M. S. Stack Engagement of Collagen-Binding Integrins Promotes Matrix Metalloproteinase-9-Dependent E-Cadherin Ectodomain Shedding in Ovarian Carcinoma Cells Cancer Res., March 1, 2007; 67(5): 2030 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Borgono, I. P. Michael, N. Komatsu, A. Jayakumar, R. Kapadia, G. L. Clayman, G. Sotiropoulou, and E. P. Diamandis A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation J. Biol. Chem., February 9, 2007; 282(6): 3640 - 3652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Illman, K. Lehti, J. Keski-Oja, and J. Lohi Epilysin (MMP-28) induces TGF-{beta} mediated epithelial to mesenchymal transition in lung carcinoma cells J. Cell Sci., September 15, 2006; 119(18): 3856 - 3865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. You, L. Waeckel, T. G. Ebrahimian, O. Blanc-Brude, P. Foubert, V. Barateau, M. Duriez, S. LeRicousse-Roussanne, J. Vilar, E. Dejana, et al. Increase in Vascular Permeability and Vasodilation Are Critical for Proangiogenic Effects of Stem Cell Therapy Circulation, July 25, 2006; 114(4): 328 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Khandoga, J. S. Kessler, M. Hanschen, A. G. Khandoga, D. Burggraf, C. Reichel, G. F. Hamann, G. Enders, and F. Krombach Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver J. Leukoc. Biol., June 1, 2006; 79(6): 1295 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Blavier, A. Lazaryev, F. Dorey, G. M. Shackleford, and Y. A. DeClerck Matrix metalloproteinases play an active role in wnt1-induced mammary tumorigenesis. Cancer Res., March 1, 2006; 66(5): 2691 - 2699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gocheva, W. Zeng, D. Ke, D. Klimstra, T. Reinheckel, C. Peters, D. Hanahan, and J. A. Joyce Distinct roles for cysteine cathepsin genes in multistage tumorigenesis Genes & Dev., March 1, 2006; 20(5): 543 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Dusek, S. Getsios, F. Chen, J. K. Park, E. V. Amargo, V. L. Cryns, and K. J. Green The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes J. Biol. Chem., February 10, 2006; 281(6): 3614 - 3624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ii, H. Yamamoto, Y. Adachi, Y. Maruyama, and Y. Shinomura Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis Experimental Biology and Medicine, January 1, 2006; 231(1): 20 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shan, Z. Lian-Fu, D. Hui, G. Wei, W. Na, J. Xia, and L. Yan Polymorphisms in the promoter regions of the matrix metalloproteinases-7, -9 and the risk of endometriosis and adenomyosis in China Mol. Hum. Reprod., January 1, 2006; 12(1): 35 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Dwivedi, G. Pino, A. Banh, Z. Nathu, D. Howchin, P. Margetts, J. G. Sivak, and J. A. West-Mays Matrix Metalloproteinase Inhibitors Suppress Transforming Growth Factor-{beta}-Induced Subcapsular Cataract Formation Am. J. Pathol., January 1, 2006; 168(1): 69 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Covington, R. C. Burghardt, and A. R. Parrish Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14) Am J Physiol Renal Physiol, January 1, 2006; 290(1): F43 - F51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X Tan, H Egami, M Abe, F Nozawa, M Hirota, and M Ogawa Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway J. Clin. Pathol., December 1, 2005; 58(12): 1242 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Xian, K. L. Schwertfeger, T. Vargo-Gogola, and J. M. Rosen Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model J. Cell Biol., November 21, 2005; 171(4): 663 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, X. Jin, S. Fang, R. Wang, Y. Li, N. Wang, W. Guo, Y. Wang, D. Wen, L. Wei, et al. The functional polymorphism in the matrix metalloproteinase-7 promoter increases susceptibility to esophageal squamous cell carcinoma, gastric cardiac adenocarcinoma and non-small cell lung carcinoma Carcinogenesis, October 1, 2005; 26(10): 1748 - 1753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Jiang, G. Davies, T. A. Martin, C. Parr, G. Watkins, M. D. Mason, K. Mokbel, and R. E. Mansel Targeting Matrilysin and Its Impact on Tumor Growth In vivo: The Potential Implications in Breast Cancer Therapy Clin. Cancer Res., August 15, 2005; 11(16): 6012 - 6019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Covington, K. J. Bayless, R. C. Burghardt, G. E. Davis, and A. R. Parrish Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases Am J Physiol Renal Physiol, August 1, 2005; 289(2): F280 - F288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Garcia-Touchard, T. D. Henry, G. Sangiorgi, L. G. Spagnoli, A. Mauriello, C. Conover, and R. S. Schwartz Extracellular Proteases in Atherosclerosis and Restenosis Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1119 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Moran, P. Iniesta, C. de Juan, C. Garcia-Aranda, A. Diaz-Lopez, and M. Benito Impairment of Stromelysin-1 Transcriptional Activity by Promoter Mutations in High Microsatellite Instability Colorectal Tumors Cancer Res., May 1, 2005; 65(9): 3811 - 3814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, X. Jin, S. Fang, Y. Li, R. Wang, W. Guo, N. Wang, Y. Wang, D. Wen, L. Wei, et al. The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma Carcinogenesis, December 1, 2004; 25(12): 2519 - 2524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Lorch, J. Klessner, J. K. Park, S. Getsios, Y. L. Wu, M. S. Stack, and K. J. Green Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells J. Biol. Chem., August 27, 2004; 279(35): 37191 - 37200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bazzoni and E. Dejana Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis Physiol Rev, July 1, 2004; 84(3): 869 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Jones, M. J. Humphreys, F. Campbell, J. P. Neoptolemos, and M. T. Boyd Comprehensive Analysis of Matrix Metalloproteinase and Tissue Inhibitor Expression in Pancreatic Cancer: Increased Expression of Matrix Metalloproteinase-7 Predicts Poor Survival Clin. Cancer Res., April 15, 2004; 10(8): 2832 - 2845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. A. DeClerck, A. M. Mercurio, M. S. Stack, H. A. Chapman, M. M. Zutter, R. J. Muschel, A. Raz, L. M. Matrisian, B. F. Sloane, A. Noel, et al. Proteases, Extracellular Matrix, and Cancer: A Workshop of the Path B Study Section Am. J. Pathol., April 1, 2004; 164(4): 1131 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. I. Wu, H. G. Munshi, R. Sen, S. J. Snipas, G. S. Salvesen, R. Fridman, and M. S. Stack Glycosylation Broadens the Substrate Profile of Membrane Type 1 Matrix Metalloproteinase J. Biol. Chem., February 27, 2004; 279(9): 8278 - 8289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.'i. Miyamoto, K. Yano, S. Sugimoto, G. Ishii, T. Hasebe, Y. Endoh, K. Kodama, M. Goya, T. Chiba, and A. Ochiai Matrix Metalloproteinase-7 Facilitates Insulin-Like Growth Factor Bioavailability through Its Proteinase Activity on Insulin-Like Growth Factor Binding Protein 3 Cancer Res., January 15, 2004; 64(2): 665 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kuefer, M. D. Hofer, J. E. Gschwend, K. J. Pienta, M. G. Sanda, A. M. Chinnaiyan, M. A. Rubin, and M. L. Day The Role of an 80 kDa Fragment of E-cadherin in the Metastatic Progression of Prostate Cancer Clin. Cancer Res., December 15, 2003; 9(17): 6447 - 6452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kremer, L. Quintanilla-Martinez, M. Fuchs, A. Gamboa-Dominguez, S. Haye, H. Kalthoff, E. Rosivatz, C. Hermannstadter, R. Busch, H. Hofler, et al. Influence of tumor-associated E-cadherin mutations on tumorigenicity and metastasis Carcinogenesis, December 1, 2003; 24(12): 1879 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J R Bebb, D P Letley, R J Thomas, F Aviles, H M Collins, S A Watson, N M Hand, A Zaitoun, and J C Atherton Helicobacter pylori upregulates matrilysin (MMP-7) in epithelial cells in vivo and in vitro in a Cag dependent manner Gut, October 1, 2003; 52(10): 1408 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Wiseman, M. D. Sternlicht, L. R. Lund, C. M. Alexander, J. Mott, M. J. Bissell, P. Soloway, S. Itohara, and Z. Werb Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis J. Cell Biol., September 15, 2003; 162(6): 1123 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. McGuire, Q. Li, and W. C. Parks Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium Am. J. Pathol., June 1, 2003; 162(6): 1831 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Visse and H. Nagase Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry Circ. Res., May 2, 2003; 92(8): 827 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mareel and A. Leroy Clinical, Cellular, and Molecular Aspects of Cancer Invasion Physiol Rev, April 1, 2003; 83(2): 337 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. da Silva Tatley, F. E. Aldwell, A. K. Dunbier, and P. J. Guilford N-Terminal E-Cadherin Peptides Act as Decoy Receptors for Listeria monocytogenes Infect. Immun., March 1, 2003; 71(3): 1580 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hirako, K. Yoshino, D. Zillikens, and K. Owaribe Extracellular Cleavage of Bullous Pemphigoid Antigen 180/Type XVII Collagen and Its Involvement in Hemidesmosomal Disassembly J. Biochem., February 1, 2003; 133(2): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rios-Doria, K. C. Day, R. Kuefer, M. G. Rashid, A. M. Chinnaiyan, M. A. Rubin, and M. L. Day The Role of Calpain in the Proteolytic Cleavage of E-cadherin in Prostate and Mammary Epithelial Cells J. Biol. Chem., January 3, 2003; 278(2): 1372 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Mei, G. L. Borchert, S. P. Donald, and J. M. Phang Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of {beta}-catenin from membrane bound E-cadherin and formation of nuclear {beta}-catenin/LEF-1 complex Carcinogenesis, December 1, 2002; 23(12): 2119 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kawano, N. Matsuo, H. Tanaka, M. Nasu, H. Yoshioka, and K. Shirabe Identification and Characterization of a Soluble Cadherin-7 Isoform Produced by Alternative Splicing J. Biol. Chem., November 27, 2002; 277(49): 47679 - 47685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Munshi, S. Ghosh, S. Mukhopadhyay, Y. I. Wu, R. Sen, K. J. Green, and M. S. Stack Proteinase Suppression by E-cadherin-mediated Cell-Cell Attachment in Premalignant Oral Keratinocytes J. Biol. Chem., October 4, 2002; 277(41): 38159 - 38167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Daniel, C. M. Spring, H. C. Crawford, A. B. Reynolds, and A. Baig The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides Nucleic Acids Res., July 1, 2002; 30(13): 2911 - 2919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Winkler and J. L. Fowlkes Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis? Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L1 - L11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Davies, W. G. Jiang, and M. D. Mason Matrilysin Mediates Extracellular Cleavage of E-Cadherin from Prostate Cancer Cells: A Key Mechanism in Hepatocyte Growth Factor/Scatter Factor-induced Cell-Cell Dissociation and in Vitro Invasion Clin. Cancer Res., October 1, 2001; 7(10): 3289 - 3297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Slaton, T. Karashima, P. Perrotte, K. Inoue, S. J. Kim, J. Izawa, D. Kedar, D. J. McConkey, R. Millikan, P. Sweeney, et al. Treatment with Low-Dose Interferon-{alpha} Restores the Balance between Matrix Metalloproteinase-9 and E-Cadherin Expression in Human Transitional Cell Carcinoma of the Bladder Clin. Cancer Res., September 1, 2001; 7(9): 2840 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. RODRIGUES, Q.-D. NGUYEN, S. FAIVRE, E. BRUYNEEL, L. THIM, B. WESTLEY, F. MAY, G. FLATAU, M. MAREEL, C. GESPACH, et al. Activation of cellular invasion by trefoil peptides and src is mediated by cyclooxygenase- and thromboxane A2 receptor-dependent signaling pathways FASEB J, July 1, 2001; 15(9): 1517 - 1528. [Abstract] [Full Text] [PDF]
|
|
