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Journal of Cell Science, Vol 114, Issue 10 1801-1809, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
T Takenawa and H Miki
Department of Biochemistry, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan. takenawa@ims.u-tokyo.ac.jp
Reorganization of cortical actin filaments plays critical roles in cell movement and pattern formation. Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1, WAVE2 and WAVE3 have been shown to regulate cortical actin filament reorganization in response to extracellular stimuli. These proteins each have a verprolin-homology (V) domain, cofilin-homology (C) domain and an acidic (A) region at the C-terminus, through which they activate the Arp2/3 complex, leading to rapid actin polymerization. N-WASP is usually present as an inactive form in which the VCA region is masked. Cooperative binding of Cdc42 and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) exposes the VCA region, activating N-WASP. In addition to this activation mechanism, WISH also activates N-WASP independently of Cdc42 and PtdIns(4,5)P(2), by binding to the proline-rich region of N-WASP. N-WASP activation induces formation of filopodia in vivo. In contrast, the ubiquitously expressed form of WAVE2 is activated downstream of Rac, leading to formation of lamellipodia. In this case, IRSp53 transmits a signal from Rac to WAVE2 through formation of a ternary Rac-IRSp53-WAVE2 complex. Thus, N-WASP, which is activated downstream of Cdc42 or independently by WISH, induces formation of filopodia and WAVE2, which is activated via IRSp53 downstream of Rac, induces formation of lamellipodia.
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|
|
|
|
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|
|
|
|
|
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|
|
|
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|
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|
|
|
|
|
|
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|
|
 |
|
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|
|
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|
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|
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|
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|
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|
|
|
|
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|
|
|
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|
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|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
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|
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|
|
 |
|
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|
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|
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|
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|
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C. F. Deroanne, D. Hamelryckx, T. T. G. Ho, C. A. Lambert, P. Catroux, C. M. Lapiere, and B. V. Nusgens Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway J. Cell Sci., March 15, 2005; 118(6): 1173 - 1183. [Abstract] [Full Text] [PDF]
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S. J. Kempiak, H. Yamaguchi, C. Sarmiento, M. Sidani, M. Ghosh, R. J. Eddy, V. DesMarais, M. Way, J. Condeelis, and J. E. Segall A Neural Wiskott-Aldrich Syndrome Protein-mediated Pathway for Localized Activation of Actin Polymerization That Is Regulated by Cortactin J. Biol. Chem., February 18, 2005; 280(7): 5836 - 5842. [Abstract] [Full Text] [PDF]
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S. Guerra, M. Aracil, R. Conde, A. Bernad, and M. Esteban Wiskott-Aldrich Syndrome Protein Is Needed for Vaccinia Virus Pathogenesis J. Virol., February 15, 2005; 79(4): 2133 - 2140. [Abstract] [Full Text] [PDF]
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T. Kawakatsu, H. Ogita, T. Fukuhara, T. Fukuyama, Y. Minami, K. Shimizu, and Y. Takai Vav2 as a Rac-GDP/GTP Exchange Factor Responsible for the Nectin-induced, c-Src- and Cdc42-mediated Activation of Rac J. Biol. Chem., February 11, 2005; 280(6): 4940 - 4947. [Abstract] [Full Text] [PDF]
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K. Kawamura, K. Takano, S. Suetsugu, S. Kurisu, D. Yamazaki, H. Miki, T. Takenawa, and T. Endo N-WASP and WAVE2 Acting Downstream of Phosphatidylinositol 3-Kinase Are Required for Myogenic Cell Migration Induced by Hepatocyte Growth Factor J. Biol. Chem., December 24, 2004; 279(52): 54862 - 54871. [Abstract] [Full Text] [PDF]
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J. Komano, K. Miyauchi, Z. Matsuda, and N. Yamamoto Inhibiting the Arp2/3 Complex Limits Infection of Both Intracellular Mature Vaccinia Virus and Primate Lentiviruses Mol. Biol. Cell, December 1, 2004; 15(12): 5197 - 5207. [Abstract] [Full Text] [PDF]
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M. Toda, M. Dawson, T. Nakamura, P. M. G. Munro, R. M. Richardson, M. Bailly, and S. J. Ono Impact of Engagement of Fc{epsilon}RI and CC Chemokine Receptor 1 on Mast Cell Activation and Motility J. Biol. Chem., November 12, 2004; 279(46): 48443 - 48448. [Abstract] [Full Text] [PDF]
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J. T. Brozinick Jr., E. D. Hawkins, A. B. Strawbridge, and J. S. Elmendorf Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues J. Biol. Chem., September 24, 2004; 279(39): 40699 - 40706. [Abstract] [Full Text] [PDF]
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D. M. Clarke, M. C. Brown, D. P. LaLonde, and C. E. Turner Phosphorylation of actopaxin regulates cell spreading and migration J. Cell Biol., September 13, 2004; 166(6): 901 - 912. [Abstract] [Full Text] [PDF]
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A. Yamada, K. Irie, A. Fukuhara, T. Ooshio, and Y. Takai Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells Genes Cells, September 1, 2004; 9(9): 843 - 855. [Abstract] [Full Text] [PDF]
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 H. Ono, T. Ichiki, K. Fukuyama, N. Iino, S. Masuda, K. Egashira, and A. Takeshita cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor-{alpha}-Induced Vascular Smooth Muscle Cell Migration Arterioscler Thromb Vasc Biol, September 1, 2004; 24(9): 1634 - 1639. [Abstract] [Full Text] [PDF]
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 T. Brembu, P. Winge, M. Seem, and A. M. Bones NAPP and PIRP Encode Subunits of a Putative Wave Regulatory Protein Complex Involved in Plant Cell Morphogenesis PLANT CELL, September 1, 2004; 16(9): 2335 - 2349. [Abstract] [Full Text] [PDF]
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G. Mouneimne, L. Soon, V. DesMarais, M. Sidani, X. Song, S.-C. Yip, M. Ghosh, R. Eddy, J. M. Backer, and J. Condeelis Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation J. Cell Biol., August 30, 2004; 166(5): 697 - 708. [Abstract] [Full Text] [PDF]
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 S. Bogdan, O. Grewe, M. Strunk, A. Mertens, and C. Klambt Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila Development, August 15, 2004; 131(16): 3981 - 3989. [Abstract] [Full Text] [PDF]
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M. Miyashita, H. Ohnishi, H. Okazawa, H. Tomonaga, A. Hayashi, T.-T. Fujimoto, N. Furuya, and T. Matozaki Promotion of Neurite and Filopodium Formation by CD47: Roles of Integrins, Rac, and Cdc42 Mol. Biol. Cell, August 1, 2004; 15(8): 3950 - 3963. [Abstract] [Full Text] [PDF]
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H. Yano, Y. Mazaki, K. Kurokawa, S. K. Hanks, M. Matsuda, and H. Sabe Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion J. Cell Biol., July 19, 2004; 166(2): 283 - 295. [Abstract] [Full Text] [PDF]
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S. Guerra, L. A. Lopez-Fernandez, R. Conde, A. Pascual-Montano, K. Harshman, and M. Esteban Microarray Analysis Reveals Characteristic Changes of Host Cell Gene Expression in Response to Attenuated Modified Vaccinia Virus Ankara Infection of Human HeLa Cells J. Virol., June 1, 2004; 78(11): 5820 - 5834. [Abstract] [Full Text] [PDF]
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A. Echarri, M. J. Lai, M. R. Robinson, and A. M. Pendergast Abl Interactor 1 (Abi-1) Wave-Binding and SNARE Domains Regulate Its Nucleocytoplasmic Shuttling, Lamellipodium Localization, and Wave-1 Levels Mol. Cell. Biol., June 1, 2004; 24(11): 4979 - 4993. [Abstract] [Full Text] [PDF]
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S. Medjkane, E. Novikov, I. Versteege, and O. Delattre The Tumor Suppressor hSNF5/INI1 Modulates Cell Growth and Actin Cytoskeleton Organization Cancer Res., May 15, 2004; 64(10): 3406 - 3413. [Abstract] [Full Text] [PDF]
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W. Ikeda, S. Kakunaga, K. Takekuni, T. Shingai, K. Satoh, K. Morimoto, M. Takeuchi, T. Imai, and Y. Takai Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner J. Biol. Chem., April 23, 2004; 279(17): 18015 - 18025. [Abstract] [Full Text] [PDF]
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A. Yamagishi, M. Masuda, T. Ohki, H. Onishi, and N. Mochizuki A Novel Actin Bundling/Filopodium-forming Domain Conserved in Insulin Receptor Tyrosine Kinase Substrate p53 and Missing in Metastasis Protein J. Biol. Chem., April 9, 2004; 279(15): 14929 - 14936. [Abstract] [Full Text] [PDF]
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X. Wu, S. Suetsugu, L. A. Cooper, T. Takenawa, and J.-L. Guan Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function J. Biol. Chem., March 5, 2004; 279(10): 9565 - 9576. [Abstract] [Full Text] [PDF]
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 N. P. Y. Lee, D. D. Mruk, A. M. Conway, and C. Y. Cheng Zyxin, Axin, and Wiskott-Aldrich Syndrome Protein Are Adaptors That Link the Cadherin/Catenin Protein Complex to the Cytoskeleton at Adherens Junctions in the Seminiferous Epithelium of the Rat Testis J Androl, March 1, 2004; 25(2): 200 - 215. [Abstract] [Full Text] [PDF]
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T. Hoshino, K. Shimizu, T. Honda, T. Kawakatsu, T. Fukuyama, T. Nakamura, M. Matsuda, and Y. Takai A Novel Role of Nectins in Inhibition of the E-Cadherin-induced Activation of Rac and Formation of Cell-Cell Adherens Junctions Mol. Biol. Cell, March 1, 2004; 15(3): 1077 - 1088. [Abstract] [Full Text] [PDF]
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