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COMMENTARY |
Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow, G12 8QQ, UK
*Author for correspondence (e-mail: N.LaThangue{at}bio.gla.ac.uk)
p300/CBP transcriptional co-activator proteins play a central role in co-ordinating and integrating multiple signal-dependent events with the transcription apparatus, allowing the appropriate level of gene activity to occur in response to diverse physiological cues that influence, for example, proliferation, differentiation and apoptosis. p300/CBP activity can be under aberrant control in human disease, particularly in cancer, which may inactivate a p300/CBP tumour-suppressor-like activity. The transcription regulating-properties of p300 and CBP appear to be exerted through multiple mechanisms. They act as protein bridges, thereby connecting different sequence-specific transcription factors to the transcription apparatus. Providing a protein scaffold upon which to build a multicomponent transcriptional regulatory complex is likely to be an important feature of p300/CBP control. Another key property is the presence of histone acetyltransferase (HAT) activity, which endows p300/CBP with the capacity to influence chromatin activity by modulating nucleosomal histones. Other proteins, including the p53 tumour suppressor, are targets for acetylation by p300/CBP. With the current intense level of research activity, p300/CBP will continue to be in the limelight and, we can be confident, yield new and important information on fundamental processes involved in transcriptional control.
Key words: Transcription, Signal transduction, Chromatin, p300/CBP, Acetyl transferase
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I. Yujnovsky, J. Hirayama, M. Doi, E. Borrelli, and P. Sassone-Corsi Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1 PNAS, April 18, 2006; 103(16): 6386 - 6391. [Abstract] [Full Text] [PDF]
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K. K. Resendes and A. G. Rosmarin GA-Binding Protein and p300 Are Essential Components of a Retinoic Acid-Induced Enhanceosome in Myeloid Cells Mol. Cell. Biol., April 15, 2006; 26(8): 3060 - 3070. [Abstract] [Full Text] [PDF]
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 Y. Tabakin-Fix, I. Azran, Y. Schavinky-Khrapunsky, O. Levy, and M. Aboud Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications Carcinogenesis, April 1, 2006; 27(4): 673 - 681. [Abstract] [Full Text] [PDF]
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E. A. Kim, Y. T. Noh, M.-J. Ryu, H.-T. Kim, S.-E. Lee, C.-H. Kim, C. Lee, Y. H. Kim, and C. Y. Choi Phosphorylation and Transactivation of Pax6 by Homeodomain-interacting Protein Kinase 2 J. Biol. Chem., March 17, 2006; 281(11): 7489 - 7497. [Abstract] [Full Text] [PDF]
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H.-C. Chuang, C.-W. Chang, G.-D. Chang, T.-P. Yao, and H. Chen Histone deacetylase 3 binds to and regulates the GCMa transcription factor Nucleic Acids Res., March 9, 2006; 34(5): 1459 - 1469. [Abstract] [Full Text] [PDF]
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S. Miyamoto, T. Kawamura, T. Morimoto, K. Ono, H. Wada, Y. Kawase, A. Matsumori, R. Nishio, T. Kita, and K. Hasegawa Histone Acetyltransferase Activity of p300 Is Required for the Promotion of Left Ventricular Remodeling After Myocardial Infarction in Adult Mice In Vivo Circulation, February 7, 2006; 113(5): 679 - 690. [Abstract] [Full Text] [PDF]
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L. H. Kasper, T. Fukuyama, M. A. Biesen, F. Boussouar, C. Tong, A. de Pauw, P. J. Murray, J. M. A. van Deursen, and P. K. Brindle Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development Mol. Cell. Biol., February 1, 2006; 26(3): 789 - 809. [Abstract] [Full Text] [PDF]
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Y.-N. Wang, Y.-J. Chen, and W.-C. Chang Activation of Extracellular Signal-Regulated Kinase Signaling by Epidermal Growth Factor Mediates c-Jun Activation and p300 Recruitment in Keratin 16 Gene Expression Mol. Pharmacol., January 1, 2006; 69(1): 85 - 98. [Abstract] [Full Text] [PDF]
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F. Faiola, X. Liu, S. Lo, S. Pan, K. Zhang, E. Lymar, A. Farina, and E. Martinez Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription Mol. Cell. Biol., December 1, 2005; 25(23): 10220 - 10234. [Abstract] [Full Text] [PDF]
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W.-Y. Chen, L.-J. Juan, and B.-c. Chung SF-1 (Nuclear Receptor 5A1) Activity Is Activated by Cyclic AMP via p300-Mediated Recruitment to Active Foci, Acetylation, and Increased DNA Binding Mol. Cell. Biol., December 1, 2005; 25(23): 10442 - 10453. [Abstract] [Full Text] [PDF]
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 C. A. Williams, D. Mondal, and K. C. Agrawal The HIV-1 Tat Protein Enhances Megakaryocytic Commitment of K562 Cells by Facilitating CREB Transcription Factor Coactivation by CBP Experimental Biology and Medicine, December 1, 2005; 230(11): 872 - 884. [Abstract] [Full Text] [PDF]
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 E. Tour, C. T. Hittinger, and W. McGinnis Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax Development, December 1, 2005; 132(23): 5271 - 5281. [Abstract] [Full Text] [PDF]
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 J. Anderson, R. Bhandari, and J. P. Kumar A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye Genetics, December 1, 2005; 171(4): 1655 - 1672. [Abstract] [Full Text] [PDF]
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H.-Y. Kuo, C.-C. Chang, J.-C. Jeng, H.-M. Hu, D.-Y. Lin, G. G. Maul, R. P. S. Kwok, and H.-M. Shih SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx PNAS, November 22, 2005; 102(47): 16973 - 16978. [Abstract] [Full Text] [PDF]
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J. H Lee, J. L Volinic, C. Banz, K.-M. Yao, and M. K Thomas Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1 J. Endocrinol., November 1, 2005; 187(2): 283 - 292. [Abstract] [Full Text] [PDF]
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T. Furumatsu, M. Tsuda, K. Yoshida, N. Taniguchi, T. Ito, M. Hashimoto, T. Ito, and H. Asahara Sox9 and p300 Cooperatively Regulate Chromatin-mediated Transcription J. Biol. Chem., October 21, 2005; 280(42): 35203 - 35208. [Abstract] [Full Text] [PDF]
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C.-W. Chang, H.-C. Chuang, C. Yu, T.-P. Yao, and H. Chen Stimulation of GCMa Transcriptional Activity by Cyclic AMP/Protein Kinase A Signaling Is Attributed to CBP-Mediated Acetylation of GCMa Mol. Cell. Biol., October 1, 2005; 25(19): 8401 - 8414. [Abstract] [Full Text] [PDF]
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R. L. Dryer and L. R. Covey A Novel NF-{kappa}B-Regulated Site within the Human I{gamma}1 Promoter Requires p300 for Optimal Transcriptional Activity J. Immunol., October 1, 2005; 175(7): 4499 - 4507. [Abstract] [Full Text] [PDF]
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V. Perrot and M. M. Rechler The Coactivator p300 Directly Acetylates the Forkhead Transcription Factor Foxo1 and Stimulates Foxo1-Induced Transcription Mol. Endocrinol., September 1, 2005; 19(9): 2283 - 2298. [Abstract] [Full Text] [PDF]
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W.-C. Huang and C.-C. Chen Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity Mol. Cell. Biol., August 1, 2005; 25(15): 6592 - 6602. [Abstract] [Full Text] [PDF]
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