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Journal of Cell Science 114, 2553-2560 (2001)
© 2001 The Company of Biologists Limited

COMMENTARY

Integrins and cell proliferation

regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

Martin Alexander Schwartz1,* and Richard K. Assoian2

1 Department of Vascular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
2 Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
* Author for correspondence (e-mail: schwartz{at}scripps.edu )

Cell cycle progression in mammalian cells is strictly regulated by both integrin-mediated adhesion to the extracellular matrix and by binding of growth factors to their receptors. This regulation is mediated by G1 phase cyclin-dependent kinases (CDKs), which are downstream of signaling pathways under the integrated control of both integrins and growth factor receptors. Recent advances demonstrate a surprisingly diverse array of integrin-dependent signals that are channeled into the regulation of the G1 phase CDKs. Regulation of cyclin D1 by the ERK pathway may provide a paradigm for understanding how cell adhesion can determine cell cycle progression.

Key words: Tyrosine kinase, Signal transduction, Growth control, Cell adhesion




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© The Company of Biologists Ltd 2001