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Journal of Cell Science 114, 2561-2568 (2001)
© 2001 The Company of Biologists Limited


COMMENTARY

Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors

Gernot Längst and Peter B. Becker*

Adolf-Butenandt-Institut, Schillerstraße 44, München 80336, Germany
* Author for correspondence (e-mail: Peter.Becker{at}mol-bio.med.uni-muenchen.de )

ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.

Key words: ISWI, Chromatin remodeling, Nucleosome assembly


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© The Company of Biologists Ltd 2001