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COMMENTARY |
Adolf-Butenandt-Institut, Schillerstraße 44,
München 80336, Germany
*
Author for correspondence (e-mail:
Peter.Becker{at}mol-bio.med.uni-muenchen.de
)
ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.
Key words: ISWI, Chromatin remodeling, Nucleosome assembly
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