QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Künzler, M. Articles by Hurt, E. Search for Related Content PubMed PubMed Citation Articles by Künzler, M. Articles by Hurt, E. Pubmed/NCBI databases Domain Gene GEO Profiles HomoloGene Social Bookmarking                         What's this?

Targeting of Ran: variation on a common theme?

Biochemie-Zentrum Heidelberg (BZH), Im Neuenheimer Feld 328, 4. OG, Heidelberg 69120, Germany

*Author for correspondence (e-mail: markus.kuenzler{at}urz.uni-heidelberg.de)

The Ran GTPase plays a key role in nucleocytoplasmic transport. In its GTP-bound form, it directly interacts with members of the importin ß family of nuclear transport receptors and modulates their association with cargo. Work in cell-free higher-eukaryote systems has demonstrated additional roles for Ran in spindle and nuclear envelope formation during mitosis. However, until recently, no Ran-target proteins in these cellular processes were known. Several groups have now identified importin ß as one important target of Ran during mitotic spindle formation. This finding suggests that Ran uses the same effectors to regulate different cellular processes.

Key words: Ran-binding, GSP1, SPI1, Karyopherins, Microtubules

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. S. Salus, J. Demeter, and S. Sazer The Ran GTPase System in Fission Yeast Affects Microtubules and Cytokinesis in Cells That Are Competent for Nucleocytoplasmic Protein Transport Mol. Cell. Biol., December 15, 2002; 22(24): 8491 - 8505. [Abstract] [Full Text] [PDF]