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COMMENTARY |
CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
Author for correspondence (e-mail: f.berditchevski{at}bham.ac.uk)
The transmembrane proteins of the tetraspanin superfamily are implicated in a diverse range of biological phenomena, including cell motility, metastasis, cell proliferation and differentiation. The tetraspanins are associated with adhesion receptors of the integrin family and regulate integrin-dependent cell migration. In cells attached to the extracellular matrix, the integrin-tetraspanin adhesion complexes are clustered into a distinct type of adhesion structure at the cell periphery. Various tetraspanins are associated with phosphatidylinositol 4-kinase and protein kinase C isoforms, and they may facilitate assembly of signalling complexes by tethering these enzymes to integrin heterodimers. At the plasma membrane, integrin-tetraspanin signalling complexes are partitioned into specific microdomains proximal to cholesterol-rich lipid rafts. A substantial fraction of tetraspanins colocalise with integrins in various intracellular vesicular compartments. It is proposed that tetraspanins can influence cell migration by one of the following mechanisms: (1) modulation of integrin signalling; (2) compartmentalisation of integrins on the cell surface; or (3) direction of intracellular trafficking and recycling of integrins.
Key words: Tetraspanin, Integrin, Migration, Signalling
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|
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Y. Murayama, J.-i. Miyagawa, K. Oritani, H. Yoshida, K. Yamamoto, O. Kishida, T. Miyazaki, S. Tsutsui, T. Kiyohara, Y. Miyazaki, et al. CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells J. Cell Sci., July 1, 2004; 117(15): 3379 - 3388. [Abstract] [Full Text] [PDF]
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M. Wadehra, L. Goodglick, and J. Braun The Tetraspan Protein EMP2 Modulates the Surface Expression of Caveolins and Glycosylphosphatidyl Inositol-linked Proteins Mol. Biol. Cell, May 1, 2004; 15(5): 2073 - 2083. [Abstract] [Full Text] [PDF]
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K. D. Little, M. E. Hemler, and C. S. Stipp Dynamic Regulation of a GPCR-Tetraspanin-G Protein Complex on Intact Cells: Central Role of CD81 in Facilitating GPR56-G{alpha}q/11 Association Mol. Biol. Cell, May 1, 2004; 15(5): 2375 - 2387. [Abstract] [Full Text] [PDF]
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M. Cortes-Canteli, M. Wagner, W. Ansorge, and A. Perez-Castillo Microarray Analysis Supports a Role for CCAAT/Enhancer-binding Protein-{beta} in Brain Injury J. Biol. Chem., April 2, 2004; 279(14): 14409 - 14417. [Abstract] [Full Text] [PDF]
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A. B. van Spriel, K. L. Puls, M. Sofi, D. Pouniotis, H. Hochrein, Z. Orinska, K.-P. Knobeloch, M. Plebanski, and M. D. Wright A Regulatory Role for CD37 in T Cell Proliferation J. Immunol., March 1, 2004; 172(5): 2953 - 2961. [Abstract] [Full Text] [PDF]
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Y.-H. Li, Y. Hou, W. Ma, J.-X. Yuan, D. Zhang, Q.-Y. Sun, and W.-H. Wang Localization of CD9 in pig oocytes and its effects on sperm-egg interaction Reproduction, February 1, 2004; 127(2): 151 - 157. [Abstract] [Full Text] [PDF]
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 T. Ishibashi, L. Ding, K. Ikenaka, Y. Inoue, K. Miyado, E. Mekada, and H. Baba Tetraspanin Protein CD9 Is a Novel Paranodal Component Regulating Paranodal Junctional Formation J. Neurosci., January 7, 2004; 24(1): 96 - 102. [Abstract] [Full Text] [PDF]
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A. Cherukuri, T. Shoham, H. W. Sohn, S. Levy, S. Brooks, R. Carter, and S. K. Pierce The Tetraspanin CD81 Is Necessary for Partitioning of Coligated CD19/CD21-B Cell Antigen Receptor Complexes into Signaling-Active Lipid Rafts J. Immunol., January 1, 2004; 172(1): 370 - 380. [Abstract] [Full Text] [PDF]
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 A. Duffield, E.-J. Kamsteeg, A. N. Brown, P. Pagel, and M. J. Caplan The tetraspanin CD63 enhances the internalization of the H,K-ATPase {beta}-subunit PNAS, December 23, 2003; 100(26): 15560 - 15565. [Abstract] [Full Text] [PDF]
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N. Chattopadhyay, Z. Wang, L. K. Ashman, S. M. Brady-Kalnay, and J. A. Kreidberg {alpha}3{beta}1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTP{micro} expression and cell-cell adhesion J. Cell Biol., December 22, 2003; 163(6): 1351 - 1362. [Abstract] [Full Text] [PDF]
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C. S. Stipp, T. V. Kolesnikova, and M. E. Hemler EWI-2 regulates {alpha}3{beta}1 integrin-dependent cell functions on laminin-5 J. Cell Biol., December 8, 2003; 163(5): 1167 - 1177. [Abstract] [Full Text] [PDF]
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 E. Ito, R. Honma, J.-i. Imai, S. Azuma, T. Kanno, S. Mori, O. Yoshie, J. Nishio, H. Iwasaki, K. Yoshida, et al. A Tetraspanin-Family Protein, T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1, Is Induced by the Ewing's Sarcoma-Wilms' Tumor 1 Fusion Protein of Desmoplastic Small Round-Cell Tumor Am. J. Pathol., December 1, 2003; 163(6): 2165 - 2172. [Abstract] [Full Text]
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H. J. Hathaway, S. C. Evans, D. H. Dubois, C. I. Foote, B. H. Elder, and B. D. Shur Mutational analysis of the cytoplasmic domain of {beta}1,4-galactosyltransferase I: influence of phosphorylation on cell surface expression J. Cell Sci., November 1, 2003; 116(21): 4319 - 4330. [Abstract] [Full Text] [PDF]
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 F. Baluska, J. Samaj, P. Wojtaszek, D. Volkmann, and D. Menzel Cytoskeleton-Plasma Membrane-Cell Wall Continuum in Plants. Emerging Links Revisited Plant Physiology, October 1, 2003; 133(2): 482 - 491. [Full Text] [PDF]
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P. Alberts, R. Rudge, I. Hinners, A. Muzerelle, S. Martinez-Arca, T. Irinopoulou, V. Marthiens, S. Tooze, F. Rathjen, P. Gaspar, et al. Cross Talk between Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein-mediated Transport and L1-mediated Adhesion Mol. Biol. Cell, October 1, 2003; 14(10): 4207 - 4220. [Abstract] [Full Text] [PDF]
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S. Deaglio, A. Capobianco, L. Bergui, J. Durig, F. Morabito, U. Duhrsen, and F. Malavasi CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells Blood, September 15, 2003; 102(6): 2146 - 2155. [Abstract] [Full Text] [PDF]
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K. G. Kohlgraf, A. J. Gawron, M. Higashi, J. L. Meza, M. D. Burdick, S. Kitajima, D. L. Kelly, T. C. Caffrey, and M. A. Hollingsworth Contribution of the MUC1 Tandem Repeat and Cytoplasmic Tail to Invasive and Metastatic Properties of a Pancreatic Cancer Cell Line Cancer Res., August 15, 2003; 63(16): 5011 - 5020. [Abstract] [Full Text] [PDF]
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X. A. Zhang, B. He, B. Zhou, and L. Liu Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration J. Biol. Chem., July 11, 2003; 278(29): 27319 - 27328. [Abstract] [Full Text] [PDF]
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S. Martinez-Arca, V. Proux-Gillardeaux, P. Alberts, D. Louvard, and T. Galli Ectopic expression of syntaxin 1 in the ER redirects TI-VAMP- and cellubrevin-containing vesicles J. Cell Sci., July 1, 2003; 116(13): 2805 - 2816. [Abstract] [Full Text] [PDF]
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J. Lammerding, A. R. Kazarov, H. Huang, R. T. Lee, and M. E. Hemler Tetraspanin CD151 regulates {alpha}6{beta}1 integrin adhesion strengthening PNAS, June 24, 2003; 100(13): 7616 - 7621. [Abstract] [Full Text] [PDF]
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S. Bauersachs, H. Blum, S. Mallok, H. Wenigerkind, S. Rief, K. Prelle, and E. Wolf Regulation of Ipsilateral and Contralateral Bovine Oviduct Epithelial Cell Function in the Postovulation Period: A Transcriptomics Approach Biol Reprod, April 1, 2003; 68(4): 1170 - 1177. [Abstract] [Full Text] [PDF]
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M. D. Gutierrez-Lopez, S. Ovalle, M. Yanez-Mo, N. Sanchez-Sanchez, E. Rubinstein, N. Olmo, M. A. Lizarbe, F. Sanchez-Madrid, and C. Cabanas A Functionally Relevant Conformational Epitope on the CD9 Tetraspanin Depends on the Association with Activated beta 1 Integrin J. Biol. Chem., January 3, 2003; 278(1): 208 - 218. [Abstract] [Full Text] [PDF]
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C. McCaig, C. M. Perks, and J. M. P. Holly Intrinsic actions of IGFBP-3 and IGFBP-5 on Hs578T breast cancer epithelial cells: inhibition or accentuation of attachment and survival is dependent upon the presence of fibronectin J. Cell Sci., November 15, 2002; 115(22): 4293 - 4303. [Abstract] [Full Text] [PDF]
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T. Uinuk-ool, W. E. Mayer, A. Sato, R. Dongak, M. D. Cooper, and J. Klein Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes PNAS, October 29, 2002; 99(22): 14356 - 14361. [Abstract] [Full Text] [PDF]
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L. G. Fradkin, J. T. Kamphorst, A. DiAntonio, C. S. Goodman, and J. N. Noordermeer Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse PNAS, October 15, 2002; 99(21): 13663 - 13668. [Abstract] [Full Text] [PDF]
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A. R. Kazarov, X. Yang, C. S. Stipp, B. Sehgal, and M. E. Hemler An extracellular site on tetraspanin CD151 determines {alpha}3 and {alpha}6 integrin-dependent cellular morphology J. Cell Biol., September 29, 2002; 158(7): 1299 - 1309. [Abstract] [Full Text] [PDF]
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Y. Kawakami, K. Kawakami, W. F. A. Steelant, M. Ono, R. C. Baek, K. Handa, D. A. Withers, and S. Hakomori Tetraspanin CD9 Is a "Proteolipid," and Its Interaction with alpha 3 Integrin in Microdomain Is Promoted by GM3 Ganglioside, Leading to Inhibition of Laminin-5-dependent Cell Motility J. Biol. Chem., September 6, 2002; 277(37): 34349 - 34358. [Abstract] [Full Text] [PDF]
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