|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 114, Issue 5 839-844, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
B Kartmann and D Roth
Max-Planck-Institute for Brain Research, Department of Neurochemistry, Deutschordenstr. 46, Germany.
In recent years a convergence of various aspects of cell biology has become apparent, and yet investigators are only beginning to grasp the underlying unifying mechanisms. Among the proteins that participate in diverse aspects of cell biology are the septins. These are a group of novel GTPase proteins that are broadly distributed in many eukaryotes except plants. Although septins were originally identified as a protein family involved in cytokinesis in yeast, recent advances in the field have now ascribed additional functions to these proteins. In particular, the number of known mammalian septin family members has increased dramatically as more data has become available through genome analyses. We suggest a classification for the mammalian septins based on the sequence homologies in their highly divergent N- and C-termini. Recent work suggests novel functions for septins in vesicle trafficking, oncogenesis and compartmentalization of the plasma membrane. Given the ability of the septins to bind GTP and phosphatidylinositol 4,5-bisphosphate in a mutually exclusive manner, these proteins might be crucial elements for the spatial and/or temporal control of diverse cellular functions. As the functions of the septins become unraveled, our understanding of seemingly different cellular processes may move a step further.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Li, D. R. Serwanski, C. P. Miralles, K.-i. Nagata, and A. L. De Blas Septin 11 Is Present in GABAergic Synapses and Plays a Functional Role in the Cytoarchitecture of Neurons and GABAergic Synaptic Connectivity J. Biol. Chem., June 19, 2009; 284(25): 17253 - 17265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Lin, Y.-M. Lin, Y.-Y. Wang, I-S. Yu, Y.-W. Lin, Y.-H. Wang, C.-M. Wu, H.-A. Pan, S.-C. Chao, P. H. Yen, et al. The Expression Level of Septin12 Is Critical for Spermiogenesis Am. J. Pathol., May 1, 2009; 174(5): 1857 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wloga, I. Strzyzewska-Jowko, J. Gaertig, and M. Jerka-Dziadosz Septins Stabilize Mitochondria in Tetrahymena thermophila Eukaryot. Cell, August 1, 2008; 7(8): 1373 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhu, F. Wang, F. Yan, P. Y. Yao, J. Du, X. Gao, X. Wang, Q. Wu, T. Ward, J. Li, et al. Septin 7 Interacts with Centromere-associated Protein E and Is Required for Its Kinetochore Localization J. Biol. Chem., July 4, 2008; 283(27): 18916 - 18925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Senese, K. Zaragoza, S. Minardi, I. Muradore, S. Ronzoni, A. Passafaro, L. Bernard, G. F. Draetta, M. Alcalay, C. Seiser, et al. Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation Mol. Cell. Biol., July 1, 2007; 27(13): 4784 - 4795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-R. Li, R. T.-H. Lee, Y.-M. Wang, X.-D. Zheng, and Y. Wang Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation J. Cell Sci., June 1, 2007; 120(11): 1898 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Kim, S. K. Seol, O.-K. Song, J. H. Park, and S. K. Jang An RNA-Binding Protein, hnRNP A1, and a Scaffold Protein, Septin 6, Facilitate Hepatitis C Virus Replication J. Virol., April 15, 2007; 81(8): 3852 - 3865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Taniguchi, M. Taoka, M. Itakura, A. Asada, T. Saito, M. Kinoshita, M. Takahashi, T. Isobe, and S.-i. Hisanaga Phosphorylation of Adult Type Sept5 (CDCrel-1) by Cyclin-dependent Kinase 5 Inhibits Interaction with Syntaxin-1 J. Biol. Chem., March 16, 2007; 282(11): 7869 - 7876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-O. Park and E. Bi Central Roles of Small GTPases in the Development of Cell Polarity in Yeast and Beyond Microbiol. Mol. Biol. Rev., March 1, 2007; 71(1): 48 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-Y. Huang, D. Kowalski, H. Minderman, N. Gandhi, and E. S. Johnson Small Ubiquitin-Related Modifier Pathway Is a Major Determinant of Doxorubicin Cytotoxicity in Saccharomyces cerevisiae Cancer Res., January 15, 2007; 67(2): 765 - 772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Low and I. G. Macara Structural Analysis of Septin 2, 6, and 7 Complexes J. Biol. Chem., October 13, 2006; 281(41): 30697 - 30706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Amir, R. Wang, H. Matzkin, J. W. Simons, and N. J. Mabjeesh MSF-A Interacts with Hypoxia-Inducible Factor-1{alpha} and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis Cancer Res., January 15, 2006; 66(2): 856 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Spiliotis and W. J. Nelson Here come the septins: novel polymers that coordinate intracellular functions and organization J. Cell Sci., January 1, 2006; 119(1): 4 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ono, M. Ihara, H. Nakajima, K. Ozaki, Y. Kataoka-Fujiwara, T. Taki, K.-i. Nagata, M. Inagaki, N. Yoshida, T. Kitamura, et al. Disruption of Sept6, a Fusion Partner Gene of MLL, Does Not Affect Ontogeny, Leukemogenesis Induced by MLL-SEPT6, or Phenotype Induced by the Loss of Sept4 Mol. Cell. Biol., December 15, 2005; 25(24): 10965 - 10978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Martin-Cuadrado, J. L. Morrell, M. Konomi, H. An, C. Petit, M. Osumi, M. Balasubramanian, K. L. Gould, F. del Rey, and C. R. V. de Aldana Role of Septins and the Exocyst Complex in the Function of Hydrolytic Enzymes Responsible for Fission Yeast Cell Separation Mol. Biol. Cell, October 1, 2005; 16(10): 4867 - 4881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Kremer, T. Haystead, and I. G. Macara Mammalian Septins Regulate Microtubule Stability through Interaction with the Microtubule-binding Protein MAP4 Mol. Biol. Cell, October 1, 2005; 16(10): 4648 - 4659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Gladfelter, L. Kozubowski, T. R. Zyla, and D. J. Lew Interplay between septin organization, cell cycle and cell shape in yeast J. Cell Sci., April 15, 2005; 118(8): 1617 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Nagata, T. Asano, Y. Nozawa, and M. Inagaki Biochemical and Cell Biological Analyses of a Mammalian Septin Complex, Sept7/9b/11 J. Biol. Chem., December 31, 2004; 279(53): 55895 - 55904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Martinez and J. Ware Mammalian Septin Function in Hemostasis and Beyond Experimental Biology and Medicine, December 1, 2004; 229(11): 1111 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. An, J. L. Morrell, J. L. Jennings, A. J. Link, and K. L. Gould Requirements of Fission Yeast Septins for Complex Formation, Localization, and Function Mol. Biol. Cell, December 1, 2004; 15(12): 5551 - 5564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-K. Ju and F.-L. Huang MSAP, the Meichroacidin Homolog of Carp (Cyprinus carpio), Differs from the Rodent Counterpart in Germline Expression and Involves Flagellar Differentiation Biol Reprod, November 1, 2004; 71(5): 1419 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kato, C. Martinez, S. Russell, P. Nurden, A. Nurden, S. Fiering, and J. Ware Genetic deletion of mouse platelet glycoprotein Ib{beta} produces a Bernard-Soulier phenotype with increased {alpha}-granule size Blood, October 15, 2004; 104(8): 2339 - 2344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Martin and J. B. Konopka SUMO Modification of Septin-interacting Proteins in Candida albicans J. Biol. Chem., September 24, 2004; 279(39): 40861 - 40867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kinoshita, K. Kimura, N. Matsumoto, M. Watanabe, M. Fukaya, and C. Ide Mammalian septin Sept2 modulates the activity of GLAST, a glutamate transporter in astrocytes Genes Cells, January 1, 2004; 9(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Dong, B. Ferger, J.-C. Paterna, D. Vogel, S. Furler, M. Osinde, J. Feldon, and H. Bueler Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1 PNAS, October 14, 2003; 100(21): 12438 - 12443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kinoshita Assembly of Mammalian Septins J. Biochem., October 1, 2003; 134(4): 491 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Caviston, M. Longtine, J. R. Pringle, and E. Bi The Role of Cdc42p GTPase-activating Proteins in Assembly of the Septin Ring in Yeast Mol. Biol. Cell, October 1, 2003; 14(10): 4051 - 4066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Warenda, S. Kauffman, T. P. Sherrill, J. M. Becker, and J. B. Konopka Candida albicans Septin Mutants Are Defective for Invasive Growth and Virulence Infect. Immun., July 1, 2003; 71(7): 4045 - 4051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Nagata, A. Kawajiri, S. Matsui, M. Takagishi, T. Shiromizu, N. Saitoh, I. Izawa, T. Kiyono, T. J. Itoh, H. Hotani, et al. Filament Formation of MSF-A, a Mammalian Septin, in Human Mammary Epithelial Cells Depends on Interactions with Microtubules J. Biol. Chem., May 9, 2003; 278(20): 18538 - 18543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Casamayor and M. Snyder Molecular Dissection of a Yeast Septin: Distinct Domains Are Required for Septin Interaction, Localization, and Function Mol. Cell. Biol., April 15, 2003; 23(8): 2762 - 2777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berlin, A. Paoletti, and F. Chang Mid2p stabilizes septin rings during cytokinesis in fission yeast J. Cell Biol., March 31, 2003; 160(7): 1083 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Lee, S. Song, H.-S. Ro, C. J. Park, J. Lippincott, R. Li, J. R. Pringle, C. De Virgilio, M. S. Longtine, and K. S. Lee Bni5p, a Septin-Interacting Protein, Is Required for Normal Septin Function and Cytokinesis in Saccharomyces cerevisiae Mol. Cell. Biol., October 1, 2002; 22(19): 6906 - 6920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Surka, C. W. Tsang, and W. S. Trimble The Mammalian Septin MSF Localizes with Microtubules and Is Required for Completion of Cytokinesis Mol. Biol. Cell, October 1, 2002; 13(10): 3532 - 3545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Warenda and J. B. Konopka Septin Function in Candida albicans Morphogenesis Mol. Biol. Cell, August 1, 2002; 13(8): 2732 - 2746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Schweitzer and C. D'Souza-Schorey Localization and Activation of the ARF6 GTPase during Cleavage Furrow Ingression and Cytokinesis J. Biol. Chem., July 19, 2002; 277(30): 27210 - 27216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Guertin, S. Trautmann, and D. McCollum Cytokinesis in Eukaryotes Microbiol. Mol. Biol. Rev., June 1, 2002; 66(2): 155 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-P. Shih, K. G. Hales, J. R. Pringle, and M. Peifer Identification of septin-interacting proteins and characterization of the Smt3/SUMO-conjugation system in Drosophila J. Cell Sci., March 15, 2002; 115(6): 1259 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dent, K. Kato, X.-R. Peng, C. Martinez, M. Cattaneo, C. Poujol, P. Nurden, A. Nurden, W. S. Trimble, and J. Ware A prototypic platelet septin and its participation in secretion PNAS, March 5, 2002; 99(5): 3064 - 3069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-R. Peng, Z. Jia, Y. Zhang, J. Ware, and W. S. Trimble The Septin CDCrel-1 Is Dispensable for Normal Development and Neurotransmitter Release Mol. Cell. Biol., January 1, 2002; 22(1): 378 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ono, T. Taki, T. Taketani, H. Kawaguchi, M. Taniwaki, T. Okamura, K. Kawa, R. Hanada, M. Kobayashi, and Y. Hayashi SEPTIN6, a Human Homologue to Mouse Septin6, Is Fused to MLL in Infant Acute Myeloid Leukemia with Complex Chromosomal Abnormalities Involving 11q23 and Xq24 Cancer Res., January 1, 2002; 62(2): 333 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tachikawa, A. Bloecher, K. Tatchell, and A. M. Neiman A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation J. Cell Biol., November 26, 2001; 155(5): 797 - 808. [Abstract] [Full Text] [PDF]
|
|
