|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 114, Issue 6 1041-1052, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
O Cremona and P De Camilli
Department of Medical Sciences, Universita del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, Italy. cremona@med.unipmn.it
Inositol phospholipids represent a minor fraction of membrane phospholipids; yet they play important regulatory functions in signaling pathways and membrane traffic. The phosphorylated inositol ring can act either as a precursor for soluble intracellular messengers or as a binding site for cytosolic or membrane proteins. Hence, phosphorylation-dephosphorylation of phosphoinositides represents a mechanism for regulation of recruitment to the membrane of coat proteins, cytoskeletal scaffolds or signaling complexes and for the regulation of membrane proteins. Recent work suggests that phosphoinositide metabolism has an important role in membrane traffic at the synapse. PtdIns(4,5)P(2) generation is implicated in the secretion of at least a subset of neurotransmitters. Furthermore, PtdIns(4,5)P(2) plays a role in the nucleation of clathrin coats and of an actin-based cytoskeletal scaffold at endocytic zones of synapses, and PtdIns(4,5)P(2) dephosphorylation accompanies the release of newly formed vesicles from these interactions. Thus, the reversible phosphorylation of inositol phospholipids may be one of the mechanisms governing the timing and vectorial progression of synaptic vesicle membranes during their exocytic-endocytic cycle.
This article has been cited by other articles:
|
|
 |
|
  P. Montaville, N. Coudevylle, A. Radhakrishnan, A. Leonov, M. Zweckstetter, and S. Becker The PIP2 binding mode of the C2 domains of rabphilin-3A Protein Sci., June 1, 2008; 17(6): 1025 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Abe, T. Inoue, T. Galvez, L. Klein, and T. Meyer Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor J. Cell Sci., May 1, 2008; 121(9): 1488 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Mason, B. E. Jacobs, and P. A. Welling AP-2-dependent Internalization of Potassium Channel Kir2.3 Is Driven by a Novel Di-hydrophobic Signal J. Biol. Chem., March 7, 2008; 283(10): 5973 - 5984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Marza, T. Long, A. Saiardi, M. Sumakovic, S. Eimer, D. H. Hall, and G. M. Lesa Polyunsaturated Fatty Acids Influence Synaptojanin Localization to Regulate Synaptic Vesicle Recycling Mol. Biol. Cell, March 1, 2008; 19(3): 833 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Osborne, P. J. Wen, C. Boucheron, H. N. Nguyen, M. Hayakawa, H. Kaizawa, P. J. Parker, N. Vitale, and F. A. Meunier PIKfyve Negatively Regulates Exocytosis in Neurosecretory Cells J. Biol. Chem., February 1, 2008; 283(5): 2804 - 2813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Stenzel, T. Ischebeck, S. Konig, A. Holubowska, M. Sporysz, B. Hause, and I. Heilmann The Type B Phosphatidylinositol-4-Phosphate 5-Kinase 3 Is Essential for Root Hair Formation in Arabidopsis thaliana PLANT CELL, January 1, 2008; 20(1): 124 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sonoda, T. Okada, S. Jahangeer, and S.-i. Nakamura Requirement of Phospholipase D for Ilimaquinone-induced Golgi Membrane Fragmentation J. Biol. Chem., November 23, 2007; 282(47): 34085 - 34092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Stahelin, D. Karathanassis, D. Murray, R. L. Williams, and W. Cho Structural and Membrane Binding Analysis of the Phox Homology Domain of Bem1p: BASIS OF PHOSPHATIDYLINOSITOL 4-PHOSPHATE SPECIFICITY J. Biol. Chem., August 31, 2007; 282(35): 25737 - 25747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ieguchi, S. Ueda, T. Kataoka, and T. Satoh Role of the Guanine Nucleotide Exchange Factor Ost in Negative Regulation of Receptor Endocytosis by the Small GTPase Rac1 J. Biol. Chem., August 10, 2007; 282(32): 23296 - 23305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Osborne, T. P. Wallis, J. L. Jimenez, J. J. Gorman, and F. A. Meunier Identification of Secretory Granule Phosphatidylinositol 4,5-Bisphosphate-interacting Proteins Using an Affinity Pulldown Strategy Mol. Cell. Proteomics, July 1, 2007; 6(7): 1158 - 1169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Stahelin, D. Karathanassis, K. S. Bruzik, M. D. Waterfield, J. Bravo, R. L. Williams, and W. Cho Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2{alpha} J. Biol. Chem., December 22, 2006; 281(51): 39396 - 39406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tanizawa, A. Kuhara, H. Inada, E. Kodama, T. Mizuno, and I. Mori Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans Genes & Dev., December 1, 2006; 20(23): 3296 - 3310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Loewen, S.-M. Lee, Y.-K. Shin, and N. E. Reist C2B Polylysine Motif of Synaptotagmin Facilitates a Ca2+-independent Stage of Synaptic Vesicle Priming In Vivo Mol. Biol. Cell, December 1, 2006; 17(12): 5211 - 5226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xu, G. Huang, and K. V. Kandror Phosphatidylinositol 4-Kinase Type II{alpha} Is Targeted Specifically to Cellugyrin-Positive Glucose Transporter 4 Vesicles Mol. Endocrinol., November 1, 2006; 20(11): 2890 - 2897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-y. Jia, S. Lamer, M. Schumann, M. R. Schmidt, E. Krause, and V. Haucke Quantitative Proteomics Analysis of Detergent-resistant Membranes from Chemical Synapses: Evidence for Cholesterol as Spatial Organizer of Synaptic Vesicle Cycling Mol. Cell. Proteomics, November 1, 2006; 5(11): 2060 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sokac and W. M. Bement Kiss-and-Coat and Compartment Mixing: Coupling Exocytosis to Signal Generation and Local Actin Assembly Mol. Biol. Cell, April 1, 2006; 17(4): 1495 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-D. Huang, E. Woodruff, R. Mohrmann, and K. Broadie Rolling Blackout Is Required for Synaptic Vesicle Exocytosis J. Neurosci., March 1, 2006; 26(9): 2369 - 2379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xie, Y. Hong, X.-Y. Ma, X.-R. Ren, S. Ackerman, L. Mei, and W.-C. Xiong DCC-dependent Phospholipase C Signaling in Netrin-1-induced Neurite Elongation J. Biol. Chem., February 3, 2006; 281(5): 2605 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Ashton and Y. A. Ushkaryov Properties of Synaptic Vesicle Pools in Mature Central Nerve Terminals J. Biol. Chem., November 4, 2005; 280(44): 37278 - 37288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Meunier, S. L. Osborne, G. R.V. Hammond, F. T. Cooke, P. J. Parker, J. Domin, and G. Schiavo Phosphatidylinositol 3-Kinase C2{alpha} Is Essential for ATP-dependent Priming of Neurosecretory Granule Exocytosis Mol. Biol. Cell, October 1, 2005; 16(10): 4841 - 4851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Castle and D. Castle Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface J. Cell Sci., August 15, 2005; 118(16): 3769 - 3780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cheng, J. A. Grodnitzky, S. Yibchok-anun, J. Ding, and W. H. Hsu Somatostatin Increases Phospholipase D Activity and Phosphatidylinositol 4,5-bisphosphate Synthesis in Clonal {beta} Cells HIT-T15 Mol. Pharmacol., June 1, 2005; 67(6): 2162 - 2172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aoyagi, T. Sugaya, M. Umeda, S. Yamamoto, S. Terakawa, and M. Takahashi The Activation of Exocytotic Sites by the Formation of Phosphatidylinositol 4,5-Bisphosphate Microdomains at Syntaxin Clusters J. Biol. Chem., April 29, 2005; 280(17): 17346 - 17352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Golub and P. Caroni PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility J. Cell Biol., April 11, 2005; 169(1): 151 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Rabenstein, N. A. Addy, B. J. Caldarone, Y. Asaka, L. M. Gruenbaum, L. L. Peters, D. M. Gilligan, R. M. Fitzsimonds, and M. R. Picciotto Impaired Synaptic Plasticity and Learning in Mice Lacking {beta}-Adducin, an Actin-Regulating Protein J. Neurosci., February 23, 2005; 25(8): 2138 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, M. Kaksonen, D. T. Madden, R. Schekman, and D. G. Drubin Interaction of Sla2p's ANTH Domain with PtdIns(4,5)P2 Is Important for Actin-dependent Endocytic Internalization Mol. Biol. Cell, February 1, 2005; 16(2): 717 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Galli and V. Haucke Cycling of Synaptic Vesicles: How Far? How Fast! Sci. Signal., December 21, 2004; 2004(264): re19 - re19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Manguikian and S. E. Barbour Cell Cycle Dependence of Group VIA Calcium-independent Phospholipase A2 Activity J. Biol. Chem., December 17, 2004; 279(51): 52881 - 52892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Ellena, J. Moulthrop, J. Wu, M. Rauch, S. Jaysinghne, J. D. Castle, and D. S. Cafiso Membrane Position of a Basic Aromatic Peptide that Sequesters Phosphatidylinositol 4,5 Bisphosphate Determined by Site-Directed Spin Labeling and High-Resolution NMR Biophys. J., November 1, 2004; 87(5): 3221 - 3233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Huang, L. Lifshitz, V. Patki-Kamath, R. Tuft, K. Fogarty, and M. P. Czech Phosphatidylinositol-4,5-Bisphosphate-Rich Plasma Membrane Patches Organize Active Zones of Endocytosis and Ruffling in Cultured Adipocytes Mol. Cell. Biol., October 15, 2004; 24(20): 9102 - 9123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Morales-Johansson, P. Jenoe, F. T. Cooke, and M. N. Hall Negative Regulation of Phosphatidylinositol 4,5-Bisphosphate Levels by the INP51-associated Proteins TAX4 and IRS4 J. Biol. Chem., September 17, 2004; 279(38): 39604 - 39610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kanzaki, M. Furukawa, W. Raab, and J. E. Pessin Phosphatidylinositol 4,5-Bisphosphate Regulates Adipocyte Actin Dynamics and GLUT4 Vesicle Recycling J. Biol. Chem., July 16, 2004; 279(29): 30622 - 30633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Roth Phosphoinositides in Constitutive Membrane Traffic Physiol Rev, July 1, 2004; 84(3): 699 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Richards, S. O. Rizzoli, and W. J. Betz Effects of wortmannin and latrunculin A on slow endocytosis at the frog neuromuscular junction J. Physiol., May 15, 2004; 557(1): 77 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gambhir, G. Hangyas-Mihalyne, I. Zaitseva, D. S. Cafiso, J. Wang, D. Murray, S. N. Pentyala, S. O. Smith, and S. McLaughlin Electrostatic Sequestration of PIP2 on Phospholipid Membranes by Basic/Aromatic Regions of Proteins Biophys. J., April 1, 2004; 86(4): 2188 - 2207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Sahin and J. A. Bibb Protein kinases talk to lipid phosphatases at the synapse PNAS, February 3, 2004; 101(5): 1112 - 1113. [Full Text] [PDF]
|
|
|
|
|
|
K. Walther, M. K. Diril, N. Jung, and V. Haucke Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin PNAS, January 27, 2004; 101(4): 964 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Lee, M. R. Wenk, Y. Kim, A. C. Nairn, and P. De Camilli Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses PNAS, January 13, 2004; 101(2): 546 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Legendre-Guillemin, S. Wasiak, N. K. Hussain, A. Angers, and P. S. McPherson ENTH/ANTH proteins and clathrin-mediated membrane budding J. Cell Sci., January 1, 2004; 117(1): 9 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Eroglu, B. Brugger, F. Wieland, and I. Sinning Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts PNAS, September 2, 2003; 100(18): 10219 - 10224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Padron, Y. J. Wang, M. Yamamoto, H. Yin, and M. G. Roth Phosphatidylinositol phosphate 5-kinase I{beta} recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis J. Cell Biol., August 18, 2003; 162(4): 693 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Aikawa and T. F.J. Martin ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis J. Cell Biol., August 18, 2003; 162(4): 647 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Stahelin, F. Long, B. J. Peter, D. Murray, P. De Camilli, H. T. McMahon, and W. Cho Contrasting Membrane Interaction Mechanisms of AP180 N-terminal Homology (ANTH) and Epsin N-terminal Homology (ENTH) Domains J. Biol. Chem., August 1, 2003; 278(31): 28993 - 28999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Cousin, C. S. Malladi, T. C. Tan, C. R. Raymond, K. J. Smillie, and P. J. Robinson Synapsin I-associated Phosphatidylinositol 3-Kinase Mediates Synaptic Vesicle Delivery to the Readily Releasable Pool J. Biol. Chem., August 1, 2003; 278(31): 29065 - 29071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Tucker, J. M. Edwardson, J. Bai, H.-J. Kim, T. F.J. Martin, and E. R. Chapman Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells J. Cell Biol., July 21, 2003; 162(2): 199 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Krauss, M. Kinuta, M. R. Wenk, P. De Camilli, K. Takei, and V. Haucke ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type I{gamma} J. Cell Biol., July 7, 2003; 162(1): 113 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, E. Crocker, S. McLaughlin, and S. O. Smith Binding of Peptides with Basic and Aromatic Residues to Bilayer Membranes: PHENYLALANINE IN THE MYRISTOYLATED ALANINE-RICH C KINASE SUBSTRATE EFFECTOR DOMAIN PENETRATES INTO THE HYDROPHOBIC CORE OF THE BILAYER J. Biol. Chem., June 6, 2003; 278(24): 21459 - 21466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Guo, M. R. Wenk, L. Pellegrini, F. Onofri, F. Benfenati, and P. De Camilli Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles PNAS, April 1, 2003; 100(7): 3995 - 4000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zamanian and R. B. Kelly Intersectin 1L Guanine Nucleotide Exchange Activity Is Regulated by Adjacent src Homology 3 Domains That Are Also Involved in Endocytosis Mol. Biol. Cell, April 1, 2003; 14(4): 1624 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Holt, A. Cooke, M. M. Wu, and L. Lagnado Bulk Membrane Retrieval in the Synaptic Terminal of Retinal Bipolar Cells J. Neurosci., February 15, 2003; 23(4): 1329 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rajebhosale, S. Greenwood, J. Vidugiriene, A. Jeromin, and S. Hilfiker Phosphatidylinositol 4-OH Kinase Is a Downstream Target of Neuronal Calcium Sensor-1 in Enhancing Exocytosis in Neuroendocrine Cells J. Biol. Chem., February 14, 2003; 278(8): 6075 - 6084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Kim, S. Chang, L. Daniell, O. Cremona, G. Di Paolo, and P. De Camilli Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice PNAS, December 24, 2002; 99(26): 17143 - 17148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. O. Rizzoli and W. J. Betz Effects of 2-(4-Morpholinyl)-8-Phenyl-4H-1-Benzopyran-4-One on Synaptic Vesicle Cycling at the Frog Neuromuscular Junction J. Neurosci., December 15, 2002; 22(24): 10680 - 10689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Freyberg, S. Bourgoin, and D. Shields Phospholipase D2 Is Localized to the Rims of the Golgi Apparatus in Mammalian Cells Mol. Biol. Cell, November 1, 2002; 13(11): 3930 - 3942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saiardi, C. Sciambi, J. M. McCaffery, B. Wendland, and S. H. Snyder Inositol pyrophosphates regulate endocytic trafficking PNAS, October 29, 2002; 99(22): 14206 - 14211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Taverna, M. Francolini, A. Jeromin, S. Hilfiker, J. Roder, and P. Rosa Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase {beta} interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis J. Cell Sci., October 15, 2002; 115(20): 3909 - 3922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, A. Gambhir, G. Hangyas-Mihalyne, D. Murray, U. Golebiewska, and S. McLaughlin Lateral Sequestration of Phosphatidylinositol 4,5-Bisphosphate by the Basic Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Is Due to Nonspecific Electrostatic Interactions J. Biol. Chem., September 6, 2002; 277(37): 34401 - 34412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Balla, G. Tuymetova, M. Barshishat, M. Geiszt, and T. Balla Characterization of Type II Phosphatidylinositol 4-Kinase Isoforms Reveals Association of the Enzymes with Endosomal Vesicular Compartments J. Biol. Chem., May 24, 2002; 277(22): 20041 - 20050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Halet, R. Tunwell, T. Balla, K. Swann, and J. Carroll The dynamics of plasma membrane PtdIns(4,5)P2 at fertilization of mouse eggs J. Cell Sci., May 15, 2002; 115(10): 2139 - 2149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hoy, A. M. Efanov, A. M. Bertorello, S. V. Zaitsev, H. L. Olsen, K. Bokvist, B. Leibiger, I. B. Leibiger, J. Zwiller, P.-O. Berggren, et al. Inositol hexakisphosphate promotes dynamin I- mediated endocytosis PNAS, May 14, 2002; 99(10): 6773 - 6777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kinuta, H. Yamada, T. Abe, M. Watanabe, S.-A. Li, A. Kamitani, T. Yasuda, T. Matsukawa, H. Kumon, and K. Takei Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol PNAS, February 20, 2002; (2002) 261715599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Skippen, D. H. Jones, C. P. Morgan, M. Li, and S. Cockcroft Mechanism of ADP Ribosylation Factor-stimulated Phosphatidylinositol 4,5-Bisphosphate Synthesis in HL60 Cells J. Biol. Chem., February 15, 2002; 277(8): 5823 - 5831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
