Journal of Cell Science, Vol 114, Issue 7 1253-1263, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

SH3 domains: complexity in moderation

BJ Mayer
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030-3301, USA.

The SH3 domain is perhaps the best-characterized member of the growing family of protein-interaction modules. By binding with moderate affinity and selectivity to proline-rich ligands, these domains play critical roles in a wide variety of biological processes ranging from regulation of enzymes by intramolecular interactions, increasing the local concentration or altering the subcellular localization of components of signaling pathways, and mediating the assembly of large multiprotein complexes. SH3 domains and their binding sites have cropped up in many hundreds of proteins in species from yeast to man, which suggests that they provide the cell with an especially handy and adaptable means of bringing proteins together. The wealth of genetic, biochemical and structural information available provides an intimate and detailed portrait of the domain, serving as a framework for understanding other modular protein-interaction domains. Processes regulated by SH3 domains also raise important questions about the nature of specificity and the overall logic governing networks of protein interactions.
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				H. S. Duffy, P. L. Sorgen, M. E. Girvin, P. O'Donnell, W. Coombs, S. M. Taffet, M. Delmar, and D. C. Spray pH-Dependent Intramolecular Binding and Structure Involving Cx43 Cytoplasmic Domains J. Biol. Chem., September 20, 2002; 277(39): 36706 - 36714. [Abstract] [Full Text] [PDF]

				A. Maximov and I. Bezprozvanny Synaptic Targeting of N-Type Calcium Channels in Hippocampal Neurons J. Neurosci., August 15, 2002; 22(16): 6939 - 6952. [Abstract] [Full Text] [PDF]

				C. Qi, J. Chang, Y. Zhu, A. V. Yeldandi, S. M. Rao, and Y.-J. Zhu Identification of Protein Arginine Methyltransferase 2 as a Coactivator for Estrogen Receptor alpha J. Biol. Chem., August 2, 2002; 277(32): 28624 - 28630. [Abstract] [Full Text] [PDF]

				T. N. Meyer, C. Schwesinger, and B. M. Denker Zonula Occludens-1 Is a Scaffolding Protein for Signaling Molecules. Galpha 12 DIRECTLY BINDS TO THE Src HOMOLOGY 3 DOMAIN AND REGULATES PARACELLULAR PERMEABILITY IN EPITHELIAL CELLS J. Biol. Chem., July 5, 2002; 277(28): 24855 - 24858. [Abstract] [Full Text] [PDF]

				E. Marion, P. J. Kaisaki, V. Pouillon, C. Gueydan, J. C. Levy, A. Bodson, G. Krzentowski, J.-C. Daubresse, J. Mockel, J. Behrends, et al. The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man Diabetes, July 1, 2002; 51(7): 2012 - 2017. [Abstract] [Full Text] [PDF]

				C. E. Alvarez, J. G. Sutcliffe, and E. A. Thomas Novel Isoform of Insulin Receptor Substrate p53/p58 Is Generated by Alternative Splicing in the CRIB/SH3-binding Region J. Biol. Chem., June 28, 2002; 277(27): 24728 - 24734. [Abstract] [Full Text] [PDF]

				S. Panni, L. Dente, and G. Cesareni In Vitro Evolution of Recognition Specificity Mediated by SH3 Domains Reveals Target Recognition Rules J. Biol. Chem., June 7, 2002; 277(24): 21666 - 21674. [Abstract] [Full Text] [PDF]

				A. Penton, A. Wodarz, and R. Nusse A Mutational Analysis of dishevelled in Drosophila Defines Novel Domains in the Dishevelled Protein as Well as Novel Suppressing Alleles of axin Genetics, June 1, 2002; 161(2): 747 - 762. [Abstract] [Full Text] [PDF]

				A. Pandey, N. Ibarrola, I. Kratchmarova, M. M. Fernandez, S. N. Constantinescu, O. Ohara, S. Sawasdikosol, H. F. Lodish, and M. Mann A Novel Src Homology 2 Domain-containing Molecule, Src-like Adapter Protein-2 (SLAP-2), Which Negatively Regulates T Cell Receptor Signaling J. Biol. Chem., May 17, 2002; 277(21): 19131 - 19138. [Abstract] [Full Text] [PDF]

				K. S. Yan, M. Kuti, S. Yan, S. Mujtaba, A. Farooq, M. P. Goldfarb, and M.-M. Zhou FRS2 PTB Domain Conformation Regulates Interactions with Divergent Neurotrophic Receptors J. Biol. Chem., May 3, 2002; 277(19): 17088 - 17094. [Abstract] [Full Text] [PDF]

				A. H. Y. Tong, B. Drees, G. Nardelli, G. D. Bader, B. Brannetti, L. Castagnoli, M. Evangelista, S. Ferracuti, B. Nelson, S. Paoluzi, et al. A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules Science, January 11, 2002; 295(5553): 321 - 324. [Abstract] [Full Text] [PDF]