|
|
|
|
|
|
|
|
|||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | |||||
Journal of Cell Science, Vol 114, Issue 7 1309-1319, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
P Goichberg, M Shtutman, A Ben-Ze'ev and B Geiger
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel. benny.geiger@weizmann.ac.il
Cadherin-mediated cell adhesion is involved in muscle differentiation from early stages of myogenic induction to late stages of myoblast interaction and fusion. (&bgr;)-Catenin is a major constituent of cadherin-based adherens junctions and also serves as a signal transduction molecule that regulates gene expression during development. In this study, we explored the involvement of (&bgr;)-catenin in myogenic differentiation. We show here that shortly after a switch from growth to differentiation medium, (&bgr;)-catenin translocates to cell-cell junctions and its levels increase. We further show that elevation of (&bgr;)-catenin levels, induced either by inhibition of its breakdown, using LiCl, or by its overexpression, suppresses the formation of adherens junctions, resulting in a sharp decline in myogenin expression and an arrest of myogenic progression. Recruitment of (&bgr;)-catenin to adherens junctions after transfection with N-cadherin restores myogenin expression in the transfected cells. These results suggest that increased cadherin-mediated adhesion and translocation of (&bgr;)-catenin to adherens junctions are involved in activating the early steps of myogenic differentiation.
This article has been cited by other articles:
|
|
 |
|
  A. Perez-Ruiz, Y. Ono, V. F. Gnocchi, and P. S. Zammit {beta}-catenin promotes self-renewal of skeletal-muscle satellite cells J. Cell Sci., May 1, 2008; 121(9): 1373 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-A. Ko, Y. Kimura, K. Matsuura, H. Yamamoto, T. Gondo, and M. Inui PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into myotubes J. Cell Sci., December 15, 2006; 119(24): 5106 - 5113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kramerova, E. Kudryashova, B. Wu, and M. J. Spencer Regulation of the M-Cadherin-{beta}-Catenin Complex by Calpain 3 during Terminal Stages of Myogenic Differentiation Mol. Cell. Biol., November 15, 2006; 26(22): 8437 - 8447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. J. van der Velden, R. C. J. Langen, M. C. J. M. Kelders, E. F. M. Wouters, Y. M. W. Janssen-Heininger, and A. M. W. J. Schols Inhibition of glycogen synthase kinase-3{beta} activity is sufficient to stimulate myogenic differentiation Am J Physiol Cell Physiol, February 1, 2006; 290(2): C453 - C462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Vertino, J. M. Taylor-Jones, K. A. Longo, E. D. Bearden, T. F. Lane, R. E. McGehee Jr., O. A. MacDougald, and C. A. Peterson Wnt10b Deficiency Promotes Coexpression of Myogenic and Adipogenic Programs in Myoblasts Mol. Biol. Cell, April 1, 2005; 16(4): 2039 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rochat, A. Fernandez, M. Vandromme, J.-P. Moles, T. Bouschet, G. Carnac, and N. J. C. Lamb Insulin and Wnt1 Pathways Cooperate to Induce Reserve Cell Activation in Differentiation and Myotube Hypertrophy Mol. Biol. Cell, October 1, 2004; 15(10): 4544 - 4555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Billottet, N. Elkhatib, J.-P. Thiery, and J. Jouanneau Targets of Fibroblast Growth Factor 1 (FGF-1) and FGF-2 Signaling Involved in the Invasive and Tumorigenic Behavior of Carcinoma Cells Mol. Biol. Cell, October 1, 2004; 15(10): 4725 - 4734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gavard, V. Marthiens, C. Monnet, M. Lambert, and R. M. Mege N-cadherin Activation Substitutes for the Cell Contact Control in Cell Cycle Arrest and Myogenic Differentiation: INVOLVEMENT OF p120 AND {beta}-CATENIN J. Biol. Chem., August 27, 2004; 279(35): 36795 - 36802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Avigdor, P. Goichberg, S. Shivtiel, A. Dar, A. Peled, S. Samira, O. Kollet, R. Hershkoviz, R. Alon, I. Hardan, et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow Blood, April 15, 2004; 103(8): 2981 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Anakwe, L. Robson, J. Hadley, P. Buxton, V. Church, S. Allen, C. Hartmann, B. Harfe, T. Nohno, A. M. C. Brown, et al. Wnt signalling regulates myogenic differentiation in the developing avian wing Development, August 1, 2003; 130(15): 3503 - 3514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Martin, R. Schneider, S. Janetzky, Z. Waibler, P. Pandur, M. Kuhl, J. Behrens, K. von der Mark, A. Starzinski-Powitz, and V. Wixler The LIM-only protein FHL2 interacts with {beta}-catenin and promotes differentiation of mouse myoblasts J. Cell Biol., October 14, 2002; 159(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Charrasse, M. Meriane, F. Comunale, A. Blangy, and C. Gauthier-Rouviere N-cadherin-dependent cell-cell contact regulates Rho GTPases and {beta}-catenin localization in mouse C2C12 myoblasts J. Cell Biol., September 3, 2002; 158(5): 953 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. J. Langen, A. M. W. J. Schols, M. C. J. M. Kelders, J. L. J. van der Velden, E. F. M. Wouters, and Y. M. W. Janssen-Heininger Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways Am J Physiol Cell Physiol, September 1, 2002; 283(3): C714 - C721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Petropoulos and I. S. Skerjanc beta -Catenin Is Essential and Sufficient for Skeletal Myogenesis in P19 Cells J. Biol. Chem., May 3, 2002; 277(18): 15393 - 15399. [Abstract] [Full Text] [PDF]
|
|
