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Journal of Cell Science, Vol 114, Issue 7 1397-1408, Copyright © 2001 by Company of Biologists
JOURNAL ARTICLES |
WP Li, P Liu, BK Pilcher and RG Anderson
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA. anders06@utsw.swmed.edu
In commonly used tissue culture cells, caveolin-1 is embedded in caveolae membranes. It appears to reach this location after being cotranslationally inserted into ER membranes, processed in the Golgi and shipped to the cell surface. We now report that caveolae are not the preferred location for caveolin-1 in all cell types. Skeletal muscle cells and keratinocytes target caveolin-1 to the cytosol while in exocrine and endocrine cells it accumulates in the secretory pathway. We also found that airway epithelial cells accumulate caveolin-1 in modified mitochondria. The cytosolic and the secreted forms appear to be incorporated into a soluble, lipid complex. We conclude that caveolin-1 can be targeted to a variety of intracellular destinations, which suggests a novel mechanism for the intracellular traffic of this protein.
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